CLINICAL VALUE OF SYNDECAN-1 LEVELS IN TRAUMA BRAIN INJURY: A META-ANALYSIS

doi:10.1097/SHK.0000000000002255

科研成果详情

题名	CLINICAL VALUE OF SYNDECAN-1 LEVELS IN TRAUMA BRAIN INJURY: A META-ANALYSIS
作者	Xie, Wei-Wei 1,2,3,4; Ding, Ya-Jun1,2,3; Bhandari, Suwas 1,2,3; Li, Hui 1,2,3; Chen, Hua-Sen 1,2,3,4; Jin, Sheng-Wei1,2,3; Weng, Hai-Xu 5; Hao, Yu1,2,3,4
发表日期	2024-01
发表期刊	SHOCK 影响因子和分区
语种	英语
原始文献类型	Article ; Meta-Analysis ; Journal Article
关键词	Traumatic brain injury syndecan-1 meta-analysis
其他关键词	COAGULOPATHY ; ENDOTHELIOPATHY ; BIOMARKERS
摘要	Background: Traumatic brain injury (TBI) is a head trauma usually associated with death and endothelial glycocalyx damage. Syndecan-1 (SDC-1)-a biomarker of glycocalyx degradation-has rarely been reported in meta-analyses to determine the clinical prognostic value in TBI patients. Methods: We looked into PubMed, EMBASE, Cochrane Library, and Web of Science databases from January 1, 1990, to May 1, 2023, to identify eligible studies. A meta-analysis was conducted using RevMan 5.4 and Stata 16.0 with the search terms SDC-1 and traumatic brain injury. Results: The present study included five studies with a total of 640 enrolled patients included. Syndecan-1 concentrations were higher in the isotrauma TBI group than in the non-TBI group (standardized mean difference [SMD] = 0.52; 95% CI: 0.03-1.00; P = 0.04). Subgroup analysis revealed statistical significance when comparing the SDC-1 level of multitrauma TBI (TBI + other injuries) group with the isotrauma TBI group (SMD = 0.74; 95% CI: 0.42-1.05; P < 0.001), and the SDC-1 level of the TBI coagulopathy (+) group (TBI with early coagulopathy) with the TBI coagulopathy (-) group (SMD = 1.75; 95% CI: 0.41-3.10; P = 0.01). Isotrauma TBI patients with higher SDC-1 level were at a higher risk of 30-day in-hospital mortality (odds ratio = 3.32; 95% CI: 1.67-6.60; P = 0.0006). Conclusion: This meta-analysis suggests that SDC-1 could be a biomarker of endotheliopathy and coagulopathy in TBI, as it was increased in isotrauma TBI patients and was higher in multitrauma TBI patients. There is a need for additional research into the use of SDC-1 as a prognostic biomarker in TBI, especially in isotrauma TBI patients.
资助项目	National Key R&D Program of China [2022YFC2504404]; Medical Health Science and Technology Project of Zhejiang Provincial Health Commission [2023RC211]; Wenzhou Municipal Science and Technology Bureau [Y20220089]; Research Grant for Students of Wenzhou Medical University [wyx2021101075]; Key Incubation Team of The Second Affiliated Hospital; Yuying Children's Hospital of Wenzhou Medical University Thousand, Hundred, TenProject [WMLEFH2022005]
出版者	LIPPINCOTT WILLIAMS & WILKINS
ISSN	1073-2322
EISSN	1540-0514
卷号	61 期号:1 页码:49-54
DOI	10.1097/SHK.0000000000002255
页数	6
WOS类目	Critical Care Medicine ; Hematology ; Surgery ; Peripheral Vascular Disease
WOS研究方向	General & Internal Medicine ; Hematology ; Surgery ; Cardiovascular System & Cardiology
WOS记录号	WOS:001157236400013
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	37878479
SCOPUSEID	2-s2.0-85184345318
通讯作者地址	[Hao, Yu]Department of Anesthesia and Critical Care,The Second Affiliated Hospital,Yuying Children's Hospital of Wenzhou Medical University,109 Xueyuan Road, Zhejiang Province,Wenzhou,325027,China ; [Weng, Hai-Xu]Department of Critical Care Medicine,The Third Affiliated Hospital of Wenzhou Medical University,108 WanSong Road, Ruian, Zhejiang Province,Wenzhou,325200,China ; [Jin, Sheng-Wei]Department of Anesthesia and Critical Care,The Second Affiliated Hospital,Yuying Children's Hospital of Wenzhou Medical University,109 Xueyuan Road, Zhejiang Province,Wenzhou,325027,China
Scopus学科分类	Emergency Medicine;Critical Care and Intensive Care Medicine
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/209960
专题	第二临床医学院、附属第二医院、育英儿童医院附属第二医院_麻醉重点学科实验室其他_附属第三医院（瑞安市人民医院）
通讯作者	Jin, Sheng-Wei; Weng, Hai-Xu; Hao, Yu
作者单位	1.Department of Anesthesia and Critical Care,The Second Affiliated Hospital,Yuying Children's Hospital of Wenzhou Medical University,Zhejiang Province,Wenzhou,China; 2.Key Laboratory of Pediatric Anesthesiology,Ministry of Education,Wenzhou Medical University,Zhejiang Province,Wenzhou,China; 3.Key Laboratory of Anesthesiology of Zhejiang Province,Wenzhou Medical University,Zhejiang Province,Wenzhou,China; 4.The Second School of Medicine,Wenzhou Medical University,Zhejiang Province,Wenzhou,China; 5.Department of Critical Care Medicine,The Third Affiliated Hospital of Wenzhou Medical University,Zhejiang Province,Wenzhou,China
第一作者单位	附属第二医院; 第二临床医学院，附属第二医院、育英儿童医院; 温州医科大学
通讯作者单位	附属第二医院; 第二临床医学院，附属第二医院、育英儿童医院; 附属第三医院（瑞安市人民医院）
第一作者的第一单位	附属第二医院
推荐引用方式 GB/T 7714	Xie, Wei-Wei,Ding, Ya-Jun,Bhandari, Suwas,et al. CLINICAL VALUE OF SYNDECAN-1 LEVELS IN TRAUMA BRAIN INJURY: A META-ANALYSIS[J]. SHOCK,2024,61(1):49-54.
APA	Xie, Wei-Wei., Ding, Ya-Jun., Bhandari, Suwas., Li, Hui., Chen, Hua-Sen., ... & Hao, Yu. (2024). CLINICAL VALUE OF SYNDECAN-1 LEVELS IN TRAUMA BRAIN INJURY: A META-ANALYSIS. SHOCK, 61(1), 49-54.
MLA	Xie, Wei-Wei,et al."CLINICAL VALUE OF SYNDECAN-1 LEVELS IN TRAUMA BRAIN INJURY: A META-ANALYSIS".SHOCK 61.1(2024):49-54.