Ameliorative effects of zinc and vitamin E against phthalates-induced reproductive toxicity in male rats

doi:10.1002/tox.24191

科研成果详情

题名	Ameliorative effects of zinc and vitamin E against phthalates-induced reproductive toxicity in male rats
作者	Xia, Ling-Zi1,2; Liu, Li-Lan1,2; Yue, Jun-Zhe1,2; Lu, Zhen-Yu1,2; Deng, Ru-Ya 1; He, Xi 1; Li, Can-Can 1; Hu, Burong2,3; Gao, Hai-Tao1,2
发表日期	2024-03-05
发表期刊	ENVIRONMENTAL TOXICOLOGY 影响因子和分区
语种	英语
原始文献类型	Article ; Early Access ; Article in Press
关键词	male reproductive toxicity phthalates steroidogenic proteins vitamin E zinc Endocrinology Esters Rats Steroid hormones Toxicity Zinc Anogenital distance Effect of zincs Male rats Male reproductive organs Male reproductive toxicity Phthalates Reproductive toxicities Sex hormones Steroidogenic protein Vitamin-E
其他关键词	ANOGENITAL DISTANCE ; EXPOSURE ; TESTIS ; LEVEL ; PIWI ; SPERMATOGENESIS ; ASSOCIATION
摘要	Objective: Phthalates (PEs) could cause reproductive harm to males. A mixture of three widely used PEs (MPEs) was used to investigate the ameliorative effects of zinc (Zn) and vitamin E (VE) against male reproductive toxicity. Methods: Fifty male SD rats were randomly divided into five groups (n = 10). Rats in MPEs group were orally treated with 160 mg/kg/d MPEs, while rats in MPEs combined Zn and/or VE groups were treated with 160 mg/kg/d MPEs plus 25 mg/kg/d Zn and/or 25 mg/kg/d VE. After intervention for 70 days, it's was measured of male reproductive organs' weight, histopathological observation of sperms and testes, serum hormones, PIWI proteins and steroidogenic proteins. Results: Compared with control, anogenital distance, testes weight, epididymides weight, and sex hormones were significantly decreased, while the sperm malformation rate was markedly increased in MPEs group (p < .05); the testicular tissues were injured in MPEs group with disordered and decreased spermatids, and arrested spermatogenesis. PIWIL1, PIWIL2, StAR, CYP11A1 and CYP19A1 were down-regulated in MPEs group (p < .05). However, the alterations of these parameters were restored in MPEs combined Zn and/or VE groups (p < .05). Conclusion: Zn and/or VE improved steroid hormone metabolism, and inhibited MPEs' male reproductive toxicity.
资助项目	Wenzhou Municipal Science and Technology Bureau
出版者	WILEY
ISSN	1520-4081
EISSN	1522-7278
卷号	39 期号:6 页码:3330-3340
DOI	10.1002/tox.24191
页数	11
WOS类目	Environmental Sciences ; Toxicology ; Water Resources
WOS研究方向	Environmental Sciences & Ecology ; Toxicology ; Water Resources
WOS记录号	WOS:001179474400001
收录类别	SCIE ; PUBMED ; EI ; SCOPUS
在线发表日期	2024-03
EI入藏号	20241115713965
EI主题词	Proteins
EI分类号	461.6 Medicine and Pharmacology ; 461.7 Health Care ; 546.3 Zinc and Alloys ; 801.2 Biochemistry ; 804.1 Organic Compounds
URL	查看原文
Pubmed记录号	38440903
Scopus记录号	2-s2.0-85186852146
通讯作者地址	[Gao, Hai-Tao]Department of Preventive Medicine,School of Public Health,Wenzhou Medical University,Zhejiang,Wenzhou,325035,China ; [Hu, Burong]Department of Radiation Medicine,School of Public Health,Wenzhou Medical University,Zhejiang,Wenzhou,325035,China
scopus学科分类	Toxicology;Management, Monitoring, Policy and Law;Health, Toxicology and Mutagenesis
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/209952
专题	公共卫生与管理学院_预防医学系公共卫生与管理学院_放射卫生与放射医学系
通讯作者	Hu, Burong; Gao, Hai-Tao
作者单位	1.Department of Preventive Medicine,School of Public Health,Wenzhou Medical University,Zhejiang,China; 2.Zhejiang Provincial Key Laboratory of Watershed Science and Health,Wenzhou Medical University,Zhejiang,China; 3.Department of Radiation Medicine,School of Public Health,Wenzhou Medical University,Zhejiang,China
第一作者单位	预防医学系; 温州医科大学
通讯作者单位	预防医学系; 温州医科大学
第一作者的第一单位	预防医学系
推荐引用方式 GB/T 7714	Xia, Ling-Zi,Liu, Li-Lan,Yue, Jun-Zhe,et al. Ameliorative effects of zinc and vitamin E against phthalates-induced reproductive toxicity in male rats[J]. ENVIRONMENTAL TOXICOLOGY,2024,39(6):3330-3340.
APA	Xia, Ling-Zi., Liu, Li-Lan., Yue, Jun-Zhe., Lu, Zhen-Yu., Deng, Ru-Ya., ... & Gao, Hai-Tao. (2024). Ameliorative effects of zinc and vitamin E against phthalates-induced reproductive toxicity in male rats. ENVIRONMENTAL TOXICOLOGY, 39(6), 3330-3340.
MLA	Xia, Ling-Zi,et al."Ameliorative effects of zinc and vitamin E against phthalates-induced reproductive toxicity in male rats".ENVIRONMENTAL TOXICOLOGY 39.6(2024):3330-3340.