Oxidative balance score was negatively associated with the risk of metabolic syndrome, metabolic syndrome severity, and all-cause mortality of patients with metabolic syndrome

doi:10.3389/fendo.2023.1233145

科研成果详情

题名	Oxidative balance score was negatively associated with the risk of metabolic syndrome, metabolic syndrome severity, and all-cause mortality of patients with metabolic syndrome
作者	Xu, Zhixiao1; Lei, Xiong1; Chu, Weiwei 2; Weng, Luoqi1; Chen, Chengshui1,3,4; Ye, Ran5
发表日期	2024-01-12
发表期刊	FRONTIERS IN ENDOCRINOLOGY 影响因子和分区
语种	英语
原始文献类型	Article
关键词	oxidative stress metabolic syndrome lifestyles diet mortality
其他关键词	REDOX BIOLOGY ; FREE-RADICALS ; STRESS ; ANTIOXIDANTS ; PATHOGENESIS ; VITAMIN-B2 ; MANAGEMENT ; DISEASE ; NIACIN ; SEX
摘要	Background The oxidative balance score (OBS), an encompassing scoring mechanism for assessing oxidative stress, is formulated based on nutritional and lifestyle components. The emergence of metabolic syndrome (MetS) is intricately linked to oxidative stress. Nonetheless, the correlation between OBS and MetS displays variability within distinct cohorts. Objective We worked on the relationships between OBS and the risk of MetS, MetS severity, and all-cause mortality of MetS patients. Methods A total of 11,171 adult participants were collected from the U.S. National Health Examination Survey (NHANES) 2007-2018. Employing survey-weighted logistic models, we evaluated the relationship between OBS and MetS risk. Furthermore, survey-weighted linear models were utilized to investigate the connection between OBS and MetS severity. Among the participants, 3,621 individuals had their survival status recorded, allowing us to employ Cox proportional hazards regression models in order to ascertain the association between OBS and the all-cause mortality within the subset of individuals with MetS. The OBS (where a higher OBS signified an increased prevalence of anti- or pro-oxidant exposures) weighed the 20 factors, while the MetS severity score weighed the five factors. Results After multivariable adjustment, individuals with elevated OBS were found to exhibit a decreased susceptibility to MetS [odds ratio (OR) 0.95; 95% CI 0.94-0.96]. The adjusted OR was 0.42 (95% CI 0.33-0.53) for MetS risk in the fourth OBS quartile compared with those in the first OBS quartile (P for trend < 0.001). A one-unit increase in OBS was linked to a 3% reduction in MetS severity score by 3% (mean difference, -0.03; 95% CI, -0.04 to -0.03). Moreover, increased OBS correlated with decreased hazard of all-cause mortality risk among MetS subjects (adjusted hazard ratio, 0.95; 95% CI, 0.93-0.98). These associations retained their strength even subsequent to the introduction of sensitivity analyses. There existed a statistically significant negative correlation between diet/lifestyle OBS and both MetS risk as well as MetS severity. Conclusions An inverse correlation was observed between OBS and the susceptibility to MetS, MetS severity, and all-cause mortality of MetS patients. Health outcomes for MetS patients were positively related to antioxidant diets and lifestyles.
资助项目	Key Laboratory of Interventional Pulmonology of Zhejiang Province [2019E10014]; Zhejiang Provincial Key Research and Development Program [2020C03067]; National Nature Science Foundation of China [82170017]
出版者	FRONTIERS MEDIA SA
ISSN	1664-2392
卷号	14
DOI	10.3389/fendo.2023.1233145
页数	11
WOS类目	Endocrinology & Metabolism
WOS研究方向	Endocrinology & Metabolism
WOS记录号	WOS:001150651500001
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	38283746
SCOPUSEID	2-s2.0-85183169143
通讯作者地址	[Chen, Chengshui]Department of Pulmonary and Critical Care Medicine,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China ; [Ye, Ran]Department of Ultrasonography,The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University,Wenzhou,China
Scopus学科分类	Endocrinology, Diabetes and Metabolism
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/209778
专题	附属第一医院第二临床医学院、附属第二医院、育英儿童医院第二临床医学院、附属第二医院、育英儿童医院_影像医学与核医学_超声科其他_温州医科大学附属衢州医院
通讯作者	Chen, Chengshui; Ye, Ran
作者单位	1.Department of Pulmonary and Critical Care Medicine,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China; 2.Department of Pulmonary and Critical Care Medicine,The Lu ‘an People’s Hospital of Anhui Province,The Lu ‘an Hospital Affiliated to Anhui Medical University,Lu ‘an,China; 3.Key Laboratory of Interventional Pulmonology of Zhejiang Province,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China; 4.The Quzhou Affiliated Hospital of Wenzhou Medical University,Quzhou People’s Hospital,Quzhou,China; 5.Department of Ultrasonography,The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University,Wenzhou,China
第一作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院
通讯作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院; 第二临床医学院，附属第二医院、育英儿童医院; 附属第二医院
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Xu, Zhixiao,Lei, Xiong,Chu, Weiwei,et al. Oxidative balance score was negatively associated with the risk of metabolic syndrome, metabolic syndrome severity, and all-cause mortality of patients with metabolic syndrome[J]. FRONTIERS IN ENDOCRINOLOGY,2024,14.
APA	Xu, Zhixiao, Lei, Xiong, Chu, Weiwei, Weng, Luoqi, Chen, Chengshui, & Ye, Ran. (2024). Oxidative balance score was negatively associated with the risk of metabolic syndrome, metabolic syndrome severity, and all-cause mortality of patients with metabolic syndrome. FRONTIERS IN ENDOCRINOLOGY, 14.
MLA	Xu, Zhixiao,et al."Oxidative balance score was negatively associated with the risk of metabolic syndrome, metabolic syndrome severity, and all-cause mortality of patients with metabolic syndrome".FRONTIERS IN ENDOCRINOLOGY 14(2024).