Lactobacillus plantarum ST-III culture supernatant protects against acute alcohol-induced liver and intestinal injury

doi:10.18632/aging.205331

科研成果详情

题名	Lactobacillus plantarum ST-III culture supernatant protects against acute alcohol-induced liver and intestinal injury
作者	Xu, Feng 1; Chen, Zengqiang2; Xie, Longteng 3; Yang, Shizhuo4; Li, Yuying 4,5; Wu, Junnan6; Wu, Yuyu6; Li, Siyuan6; Zhang, Xie 7; Ma, Yanyan 1; Liu, Yanlong6; Zeng, Aibing 8; Xu, Zeping 7
发表日期	2024-02-15
发表期刊	AGING-US 影响因子和分区
语种	英语
原始文献类型	Article ; Journal Article
关键词	lactobacillus plantarum ST-III alcoholic liver disease oxidative stress ER stress inflammatory
其他关键词	DISEASE ; CONSUMPTION ; MICROBIOTA ; STRESS ; ASMASE
摘要	The beneficial effects of probiotics have been studied in inflammatory bowel disease, nonalcoholic steatohepatitis, and alcoholic liver disease (ALD). Probiotic supplements are safer and more effective; however, their potential mechanisms are unclear. An objective of the current study was to examine the effects of extracellular products of Lactobacillus plantarum on acute alcoholic liver injury. Mice on a standard chow diet were supplemented with Lactobacillus plantarum ST -III culture supernatant (LP-cs) for two weeks and administered alcohol at 6 g/kg body weight by gavage. Alcohol -induced liver injury was assessed by measuring plasma alanine aminotransferase activity levels and triglyceride content determined liver steatosis. Intestinal damage and tight junctions were assessed using histochemical staining. LP-cs significantly inhibited alcoholinduced fat accumulation, inflammation, and apoptosis by inhibiting oxidative stress and endoplasmic reticulum stress. LP-cs significantly inhibited alcohol -induced intestinal injury and endotoxemia. These findings suggest that LP-cs alleviates acute alcohol -induced liver damage by inhibiting oxidative stress and endoplasmic reticulum stress via one mechanism and suppressing alcohol -induced increased intestinal permeability and endotoxemia via another mechanism. LP-cs supplements are a novel strategy for ALD prevention and treatment.
资助项目	Natural Science Foundation of China [31770552, 81300311]; Natural Science Foundation of Ningbo [2021J285, 2021J286, 202003N4235, 202003N4290]; Ningbo Leading Academic Discipline Project of Medical and Health Science [2022-X27]; Ningbo Medical and Health Leading Academic Discipline Project [2022-F06]; Science and Technology Plan Project of Wenzhou in China [Y2020218]; Ninghai County Social Development Science and Technology Project [202301]; Project of Zhejiang Medical and Health Platform Plan [2020KY908]
出版者	IMPACT JOURNALS LLC
ISSN	1945-4589
卷号	16 期号:3 页码:2077-2089
DOI	10.18632/aging.205331
页数	13
WOS类目	Cell Biology ; Geriatrics & Gerontology
WOS研究方向	Cell Biology ; Geriatrics & Gerontology
WOS记录号	WOS:001163813000049
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	38126998
SCOPUSEID	2-s2.0-85185705945
通讯作者地址	[Xu, Zeping]Department of Pharmacy,Ningbo Medical Center Li Huili Hospital,The Affiliated Hospital of Ningbo University,Ningbo,315000,China ; [Zeng, Aibing]School of Laboratory Medicine and Life Sciences,Wenzhou Medical University,Wenzhou,325035,China
Scopus学科分类	Aging;Cell Biology
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/209738
专题	附属第一医院检验医学院（生命科学学院、生物学实验教学中心）药学院（分析测试中心）精神医学学院其他_附属第三医院（瑞安市人民医院）其他_附属象山医院（象山县第一人民医院）其他_附属萧山医院（杭州市萧山区第一人民医院）
通讯作者	Zeng, Aibing; Xu, Zeping
作者单位	1.Department of Gastroenterology,Ningbo Medical Center Li Huili Hospital,The Affiliated Hospital of Ningbo University,Ningbo,315000,China; 2.Healthcare Center,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China; 3.Department of Infection Diseases,The Affiliated Xiangshan Hospital of Wenzhou Medical University,Ningbo,315700,China; 4.School of Pharmaceutical Sciences,Wenzhou Medical University,Wenzhou,325035,China; 5.Ruian People's Hospital,Wenzhou Medical College Affiliated Third Hospital,Wenzhou,325200,China; 6.School of Mental Health,Wenzhou Medical University,Wenzhou,325035,China; 7.Department of Pharmacy,Ningbo Medical Center Li Huili Hospital,The Affiliated Hospital of Ningbo University,Ningbo,315000,China; 8.School of Laboratory Medicine and Life Sciences,Wenzhou Medical University,Wenzhou,325035,China
通讯作者单位	检验医学院（生命科学学院、生物学实验教学中心）
推荐引用方式 GB/T 7714	Xu, Feng,Chen, Zengqiang,Xie, Longteng,et al. Lactobacillus plantarum ST-III culture supernatant protects against acute alcohol-induced liver and intestinal injury[J]. AGING-US,2024,16(3):2077-2089.
APA	Xu, Feng., Chen, Zengqiang., Xie, Longteng., Yang, Shizhuo., Li, Yuying., ... & Xu, Zeping. (2024). Lactobacillus plantarum ST-III culture supernatant protects against acute alcohol-induced liver and intestinal injury. AGING-US, 16(3), 2077-2089.
MLA	Xu, Feng,et al."Lactobacillus plantarum ST-III culture supernatant protects against acute alcohol-induced liver and intestinal injury".AGING-US 16.3(2024):2077-2089.