Mid-term outcomes of microfragmented adipose tissue plus arthroscopic surgery for knee osteoarthritis: A randomized, active-control, multicenter clinical trial

doi:10.4252/wjsc.v15.i12.1063

科研成果详情

题名	Mid-term outcomes of microfragmented adipose tissue plus arthroscopic surgery for knee osteoarthritis: A randomized, active-control, multicenter clinical trial
作者	Wu, Cong-Zi 1; Shi, Zhen-Yu 2; Wu, Zhen 3; Lin, Wen-Jun4; Chen, Wei-Bo 5; Jia, Xue-Wen 6; Xiang, Si-Cheng 7; Xu, Hui-Hui 7; Ge, Qin-Wen 7; Zou, Kai-Ao 7; Wang, Xu 7; Chen, Jia-Li 2; Wang, Ping-Er 2; Yuan, Wen-Hua 2; Jin, Hong-Ting 2; Tong, Pei-Jian 2,8
发表日期	2023-12-26
发表期刊	WORLD JOURNAL OF STEM CELLS 影响因子和分区
语种	英语
原始文献类型	Article ; Journal Article
关键词	Osteoarthritis Microfragmented adipose tissue Lipogems Arthroscopic surgery Knee
其他关键词	CARTILAGE REPAIR ; FAT TISSUE ; LIPOASPIRATE ; INJECTION ; PAIN
摘要	BACKGROUNDOsteoarthritis (OA) is the most prevalent form of degenerative whole-joint disease. Before the final option of knee replacement, arthroscopic surgery was the most widely used joint-preserving surgical treatment. Emerging regenerative therapies, such as those involving platelet-rich plasma, mesenchymal stem cells, and microfragmented adipose tissue (MFAT), have been pushed to the forefront of treatment to prevent the progression of OA. Currently, MFAT has been successfully applied to treat different types of orthopedic diseases. AIMTo assess the efficacy and safety of MFAT with arthroscopic surgery in patients with knee OA (KOA). METHODSA randomized, multicenter study was conducted between June 2017 and November 2022 in 10 hospitals in Zhejiang, China. Overall, 302 patients diagnosed with KOA (Kellgren-Lawrence grades 2-3) were randomized to the MFAT group (n = 151, were administered MFAT following arthroscopic surgery), or the control group (n = 151, were administered hyaluronic acid following arthroscopic surgery). The study outcomes were changes in the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) score, the visual analog scale (VAS) score, the Lequesne index score, the Whole-Organ Magnetic Resonance Imaging Score (WORMS), and safety over a 24-mo period from baseline. RESULTSThe changes in the WOMAC score (including the three subscale scores), VAS pain score, and Lequesne index score at the 24-mo mark were significantly different in the MFAT and control groups, as well as when comparing values at the posttreatment visit and those at baseline (P < 0.001). The MFAT group consistently demonstrated significant decreases in the WOMAC pain scores and VAS scores at all follow-ups compared to the control group (P < 0.05). Furthermore, the WOMAC stiffness score, WOMAC function score, and Lequesne index score differed significantly between the groups at 12 and 24 mo (P < 0.05). However, no signi?cant between-group differences were observed in the WORMS at 24 mo (P = 0.367). No serious adverse events occurred in both groups. CONCLUSIONThe MFAT injection combined with arthroscopic surgery treatment group showed better mid-term clinical outcomes compared to the control group, suggesting its efficacy as a therapeutic approach for patients with KOA.
资助项目	National Natural Science Foundation of China [82274547]; Major Program of the National Natural Science Foundation of Zhejiang Province [LD22C060002]; State Administration of Traditional Chinese Medicine of Zhejiang Province [GZY-ZJ-KJ-23064]; Zhejiang Provincial Research Foundation for Basic Public Welfare Research [LGF20H270005]
出版者	BAISHIDENG PUBLISHING GROUP INC
ISSN	1948-0210
卷号	15 期号:12
DOI	10.4252/wjsc.v15.i12.1063
页数	15
WOS类目	Cell & Tissue Engineering ; Cell Biology
WOS研究方向	Cell Biology
WOS记录号	WOS:001141686700004
收录类别	SCIE ; PUBMED
URL	查看原文
PubMed ID	38179213
通讯作者地址	[Tong, Pei-Jian]Zhejiang Chinese Med Univ, Affiliated Hosp 1, Dept Orthoped & Traumatol, 54 Youdian St, Hangzhou 310006, Zhejiang, Peoples R China.
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/209610
专题	附属第一医院_神经外科
通讯作者	Tong, Pei-Jian
作者单位	1.Zhejiang Chinese Med Univ, Affiliated Hosp 1, Inst Orthopaed & Traumatol Zhejiang Prov, Hangzhou 310053, Zhejiang, Peoples R China; 2.Zhejiang Chinese Med Univ, Affiliated Hosp 1, Dept Orthoped Surg, Hangzhou 310006, Zhejiang, Peoples R China; 3.Tongde Hosp Zhejiang Prov, Dept Orthopaed Surg, Hangzhou 310012, Peoples R China; 4.Wenzhou Med Univ, Affiliated Hosp 1, Dept Neurosurg, Wenzhou 325000, Zhejiang, Peoples R China; 5.Ruian Hosp Tradit Chinese Med, Dept Orthopaed Surg, Wenzhou 325299, Zhejiang, Peoples R China; 6.Ningbo First Hosp, Dept Orthopaed, Ningbo 315010, Zhejiang, Peoples R China; 7.Zhejiang Chinese Med Univ, Coll Clin Med 1, Hangzhou 310053, Zhejiang, Peoples R China; 8.Zhejiang Chinese Med Univ, Affiliated Hosp 1, Dept Orthoped & Traumatol, 54 Youdian St, Hangzhou 310006, Zhejiang, Peoples R China
推荐引用方式 GB/T 7714	Wu, Cong-Zi,Shi, Zhen-Yu,Wu, Zhen,et al. Mid-term outcomes of microfragmented adipose tissue plus arthroscopic surgery for knee osteoarthritis: A randomized, active-control, multicenter clinical trial[J]. WORLD JOURNAL OF STEM CELLS,2023,15(12).
APA	Wu, Cong-Zi., Shi, Zhen-Yu., Wu, Zhen., Lin, Wen-Jun., Chen, Wei-Bo., ... & Tong, Pei-Jian. (2023). Mid-term outcomes of microfragmented adipose tissue plus arthroscopic surgery for knee osteoarthritis: A randomized, active-control, multicenter clinical trial. WORLD JOURNAL OF STEM CELLS, 15(12).
MLA	Wu, Cong-Zi,et al."Mid-term outcomes of microfragmented adipose tissue plus arthroscopic surgery for knee osteoarthritis: A randomized, active-control, multicenter clinical trial".WORLD JOURNAL OF STEM CELLS 15.12(2023).