| 题名 | Phototherapy for age-related brain diseases: Challenges, successes and future |
| 作者 | |
| 发表日期 | 2024-02 |
| 发表期刊 | AGEING RESEARCH REVIEWS 影响因子和分区 |
| 语种 | 英语 |
| 原始文献类型 | Review ; Journal Article |
| 关键词 | Phototherapy Age -related brain diseases Pharmaceutical interventions Physical therapy Photosensitive protein age-related brain diseases pharmaceutical interventions photosensitive protein phototherapy physical therapy |
| 其他关键词 | LOW-LEVEL LASER ; NEAR-INFRARED LIGHT ; INTERSTITIAL PHOTODYNAMIC THERAPY ; QUALITY-OF-LIFE ; ALZHEIMERS-DISEASE ; PHOTOBIOMODULATION THERAPY ; MITOCHONDRIAL DYSFUNCTION ; PARKINSONS-DISEASE ; OXIDATIVE STRESS ; DOUBLE-BLIND |
| 摘要 | Brain diseases present a significant obstacle to both global health and economic progress, owing to their elusive pathogenesis and the limited effectiveness of pharmaceutical interventions. Phototherapy has emerged as a promising non-invasive therapeutic modality for addressing age-related brain disorders, including stroke, Alzheimer's disease (AD), and Parkinson's disease (PD), among others. This review examines the recent progressions in phototherapeutic interventions. Firstly, the article elucidates the various wavelengths of visible light that possess the capability to penetrate the skin and skull, as well as the pathways of light stimulation, encompassing the eyes, skin, veins, and skull. Secondly, it deliberates on the molecular mechanisms of visible light on photosensitive proteins, within the context of brain disorders and other molecular pathways of light modulation. Lastly, the practical application of phototherapy in diverse clinical neurological disorders is indicated. Additionally, this review presents novel approaches that combine phototherapy and pharmacological interventions. Moreover, it outlines the limitations of phototherapeutics and proposes innovative strategies to improve the treatment of cerebral disorders. |
| 资助项目 | State Natural Sciences Foundation Monumental Projects [62394314]; National Natural Science Foundation of China [82071214, 12171330]; National Major Scientific Research Instrument Development Project [61827808]; Summit Program of Foshan [2019B008]; Shenzhen Science and Technology Program [KQTD2018041218 1221912]; Fund of Talent Launch Project of Oujiang Laboratory [OJQDSP2022011]; Kangning Hospital [SLC202304] |
| 出版者 | ELSEVIER IRELAND LTD |
| ISSN | 1568-1637 |
| EISSN | 1872-9649 |
| 卷号 | 94 |
| DOI | 10.1016/j.arr.2024.102183 |
| 页数 | 17 |
| WOS类目 | Cell Biology ; Geriatrics & Gerontology |
| WOS研究方向 | Cell Biology ; Geriatrics & Gerontology |
| WOS记录号 | WOS:001167383200001 |
| 收录类别 | SCIE ; PUBMED ; SCOPUS |
| 在线发表日期 | 2024-01 |
| URL | 查看原文 |
| PubMed ID | 38218465 |
| SCOPUSEID | 2-s2.0-85184834194 |
| 通讯作者地址 | [Han, Hongbin]Key Laboratory of Alzheimer's Disease of Zhejiang Province,Institute of Aging,School of Mental Health,Wenzhou Medical University,Wenzhou,325035,China |
| Scopus学科分类 | Biotechnology;Biochemistry;Aging;Molecular Biology;Neurology |
| TOP期刊 | TOP期刊 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | https://kms.wmu.edu.cn/handle/3ETUA0LF/209526 |
| 专题 | 其他_附属康宁医院（温州市康宁医院） 第一临床医学院（信息与工程学院）、附属第一医院 附属第一医院 精神医学学院 卓越中心_老年研究院 其他_瓯江实验室 |
| 通讯作者 | Han, Hongbin |
| 作者单位 | 1.Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine,Vision and Brain Health),Institute of Aging,Key Laboratory of Alzheimer's Disease of Zhejiang Province,Zhejiang Provincial Clinical Research Center for Mental Disorders,The Affiliated Wenzhou Kangning Hospital,School of Mental Health,Wenzhou Medical University,Zhejiang,Wenzhou,325035,China; 2.Department of neurology,the first affiliated hospital of Wenzhou medical University,Wenzhou,325035,China; 3.Department of Radiology,Peking University Third Hospital,Beijing,China. Key Laboratory of Magnetic Resonance Imaging Equipment and Technique,NMPA key Laboratory for Evaluation of Medical Imaging Equipment and Technique,Institute of Medical Technology,Peking University Health Science Center,Beijing,100191,China |
| 第一作者单位 | 精神医学学院; 瓯江实验室 |
| 通讯作者单位 | 精神医学学院 |
| 第一作者的第一单位 | 精神医学学院 |
| 推荐引用方式 GB/T 7714 | Ding, Ling,Gu, Ziqi,Chen, Haishu,et al. Phototherapy for age-related brain diseases: Challenges, successes and future[J]. AGEING RESEARCH REVIEWS,2024,94. |
| APA | Ding, Ling., Gu, Ziqi., Chen, Haishu., Wang, Panpan., Song, Yilan., ... & Tong, Zhiqian. (2024). Phototherapy for age-related brain diseases: Challenges, successes and future. AGEING RESEARCH REVIEWS, 94. |
| MLA | Ding, Ling,et al."Phototherapy for age-related brain diseases: Challenges, successes and future".AGEING RESEARCH REVIEWS 94(2024). |
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