Facile strategy for gelatin-based hydrogel with multifunctionalities to remodel wound microenvironment and accelerate healing of acute and diabetic wounds

doi:10.1016/j.ijbiomac.2023.128372

科研成果详情

题名	Facile strategy for gelatin-based hydrogel with multifunctionalities to remodel wound microenvironment and accelerate healing of acute and diabetic wounds
作者	Wang, Chenglong 1; Chen, Hua 2; Wang, Wenchao 3; Yan, Guo 5; Zheng, Shengwu 6; Wang, Cheng 7; Li, Na 4; Tang, Hongli3
发表日期	2024-01
发表期刊	INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 影响因子和分区
语种	英语
原始文献类型	Article ; Early Access ; Journal Article
关键词	Chronic wounds Quercetin Antioxidant Microenvironment Reactive oxygen species
其他关键词	OXIDATIVE STRESS ; ROS
摘要	Chronic diabetic wounds represent the most common diabetes complication. Wound healing depends on scavenging reactive oxygen species (ROS), neovascularization, and controlling infection. A naturally derived gelatin -based hydrogel is biocompatible, biodegradable, does not promote inflammation, and can remove ROS, but strategies for developing a gelatin-based hydrogel currently require careful chemical modification of gelatin and time-consuming purification and post-crosslinking processing. Herein, a facile method of combining zirconium (Zr4+), gelatin, and quercetin (QCN) to generate an injectable gelatin-based hydrogel (QCN@Gel-Zr) for diabetic wound treatment was presented. Adding QCN improved the mechanical, injection, and adhesive performance of the Gel-Zr hydrogel and conferred antibacterial and free radical-scavenging abilities. These properties induced cellular proliferation and migration, protection against oxidative stress, and reduction in inflammatory expression. In vivo models of acute and chronic diabetic skin wounds were used to demonstrate biocompatibility and the ability of the gelatin hydrogels to promote wound healing. The histological analysis showed that the QCN@Gel-Zr hydrogel promoted angiogenesis, collagen deposition, and hair follicle regeneration with no detectable cytotoxicity. This study demonstrates the preparation of gelatin-based hydrogel with various flexible functions to address the complex biological requirements of diabetic wound repair.
资助项目	Wenzhou Science and Technology Project [ZG2021033, 2021HZSY0069]; Wenzhou Institute of UCAS [WIUCASQD2021032]
出版者	ELSEVIER
ISSN	0141-8130
EISSN	1879-0003
卷号	256 期号:Pt 1
DOI	10.1016/j.ijbiomac.2023.128372
页数	12
WOS类目	Biochemistry & Molecular Biology ; Chemistry, Applied ; Polymer Science
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry ; Polymer Science
WOS记录号	WOS:001131616200001
收录类别	SCIE ; PUBMED ; SCOPUS ; EI
在线发表日期	2023-11
EI入藏号	20234915147291
EI主题词	Hydrogels
EI分类号	461.9 Biology ; 461.9.1 Immunology ; 801.3 Colloid Chemistry ; 802.2 Chemical Reactions ; 804 Chemical Products Generally ; 804.1 Organic Compounds
URL	查看原文
PubMed ID	38000588
SCOPUSEID	2-s2.0-85178357107
通讯作者地址	[Wang, Cheng]Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University,Linhai,317000,China
Scopus学科分类	Structural Biology;Biochemistry;Molecular Biology
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/209440
专题	附属第一医院第一临床医学院（信息与工程学院）、附属第一医院第一临床医学院（信息与工程学院）、附属第一医院_麻醉科附属台州医院其他_附属台州医院（浙江省台州医院）
通讯作者	Wang, Chenglong
作者单位	1.Department of Orthopaedics Surgery,Shandong Provincial Hospital Affiliated to Shandong First Medical University,Jinan City,250021,China; 2.Department of Thoracic Surgery,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325003,China; 3.Department of Anesthesiology,Wenzhou Key Laboratory of perioperative medicine,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China; 4.Wenzhou Institute,University of Chinese Academy of Sciences,Wenzhou,325001,China; 5.Hunan Provincial Key Laboratory of Advanced Materials for New Energy Storage and Conversion,School of Materials Science and Engineering,Hunan University of Science and Technology,Xiangtan,411201,China; 6.Wenzhou Celecare Medical Instruments Co. Ltd,Wenzhou,325000,China; 7.Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University,Linhai,317000,China
通讯作者单位	附属台州医院（浙江省台州医院）; 附属台州医院
推荐引用方式 GB/T 7714	Wang, Chenglong,Chen, Hua,Wang, Wenchao,et al. Facile strategy for gelatin-based hydrogel with multifunctionalities to remodel wound microenvironment and accelerate healing of acute and diabetic wounds[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2024,256(Pt 1).
APA	Wang, Chenglong., Chen, Hua., Wang, Wenchao., Yan, Guo., Zheng, Shengwu., ... & Tang, Hongli. (2024). Facile strategy for gelatin-based hydrogel with multifunctionalities to remodel wound microenvironment and accelerate healing of acute and diabetic wounds. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 256(Pt 1).
MLA	Wang, Chenglong,et al."Facile strategy for gelatin-based hydrogel with multifunctionalities to remodel wound microenvironment and accelerate healing of acute and diabetic wounds".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 256.Pt 1(2024).