Details of Research Outputs

TitleEdoxaban versus Warfarin in Patients with Atrial Fibrillation
Creator
Giugliano, Robert P.1,2; Ruff, Christian T.1,2; Braunwald, Eugene1,2; Murphy, Sabina A.1,2; Wiviott, Stephen D.1,2; Halperin, Jonathan L.3; Waldo, Albert L.4; Ezekowitz, Michael D.5; Weitz, Jeffrey I.6; Spinar, Jindrich7; Ruzyllo, Witold8; Ruda, Mikhail9; Koretsune, Yukihiro10; Betcher, Joshua11; Shi, Minggao12; Grip, Laura T.1,2; Patel, Shirali P.11; Patel, Indravadan12; Hanyok, James J.12; Mercuri, Michele12; Vogelmann, O.13; Gonzalez, C.13; Ahuad Guerrero, R.14; Rodriguez, M.14,62,212; Albisu, J.15; Rosales, E.15; Allall, O.16; Reguero, M.16; Alvarez, C.17; Garcia, M.17; Ameriso, S.18; Ameriso, P.18; Amuchastegui, M.19; Caceres, M.19; Beloscar, J.20; Petrucci, J.20; Berli, M.21; Budassi, N.22; Valle, M.22; Bustamante Labarta, G.23; Saravia, M.23; Caccavo, A.24; Fracaro, V.24; Cartasegna, L.25; Novas, V.25; Caruso, O.26; Saa Zarandon, R.26; Colombo, H.27; Morandini, M.27; Cuello, J.28; Rosell, M.28; Cuneo, C.29; Bocanera, M.29; D'Amico, A.30; Cendali, G.30; Dran, R.31; Moreno, V.31; Estol, C.32; Davolos, M.32; Facello, A.33; Facello, M.33; Falu, E.34; Iriarte, M.34; Femenia, F.35; Arrieta, M.35; Fuselli, J.36; Zanotti, A.36; Gant Lopez, J.37; Meiller, F.37; Garcia Duran, R.38; Perlo, D.38; Garrido, M.39; Ceirano, C.39; Giacomi, G.40; Eden, M.40; Giannaula, R.41; Huerta, M.41; Goicoechea, R.42; von Wulffen, M.42; Hominal, M.43; Bianchini, M.43; Jure, H.44; Jure, D.44; Kevorkian, R.45; Monaco, F.45; Lanternier, G.46; Belcuore, M.46; Liniado, G.47; Iglesias, M.47; Litvak, B.48; Nigro, A.48; Llanos, J.49; Vignau, S.49; Lorente, C.50; Shatsky, K.50; Lotti, J.51; Raimondi, G.51; Mackinnon, I.52; Carne, M.52; Manuale, O.53; Calderon, M.53; Marino, J.54; Funes, I.54; Muntaner, J.55; Gandur, H.55; Nul, D.56; Verdini, E.56; Piskorz, D.57; Tommasi, A.57; Povedano, G.58; Casares, E.58; Pozzer, D.59; Fernandez, E.59; Prado, A.60; Venturini, C.60; Ramos, H.61; Navarrete, S.61; Alvarez, M.62; Sanchez, A.63; Bowen, L.63; Sanjurjo, M.64; Codutti, O.64; Saravia Toledo, S.65; Formoso, I.65; Schmidberg, J.66; Goloboulicz, A.66; Schygiel, P.67; Buzzetti, C.67; Severino, P.68; Morara, P.68; Sosa Liprandi, M.69; Teves, M.69; Vico, M.70; Morell, Y.70; Anderson, C.71; Paraskevaidis, T.71; Arstall, M.72; Hoffmann, B.72; Colquhoun, D.73; Price-Smith, S.73; Crimmins, D.74; Slattery, A.74; Dart, A.75; Kay, S.75; Davis, S.76; Silver, G.76; Flecknoe-Brown, S.77; Roberts, J.77; Gates, P.78; Jones, S.78; Lehman, R.79; Morrison, H.79; McKeirnan, M.80; Li, J.80; Paul, V.81; Batta, C.81; Purnell, P.82; Perrett, L.82; Szto, G.83; O'Shea, V.83; Capiau, L.; Banaeian, F.; De Bleecker, J.84; de Koning, K.84; De Tollenaere, M.85; De Bruyne, L.85; Desfontaines, P.86; Tincani, G.86; Heidbuchel, H.87; Meeusen, K.87; Herzet, J.88; Malmendier, D.88; Mairesse, G.89; Raepers, M.89; Parque, J.90; Clinckemaille, N.90; Scavee, C.91; Huyberechts, D.91; Stockman, D.92; Jacobs, C.92; Vandekerckhove, Y.93; Derycker, K.93; Vanwelden, J.94; van Welden, J.94; Vervoort, G.95; Mestdagh, I.95; Vrolix, M.96; Beerts, C.96; Wollaert, B.97; Denie, D.97; Vincenzo de Paola, A. 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Date Issued2013-11-28
Source PublicationNEW ENGLAND JOURNAL OF MEDICINE   Impact Factor & Quartile
language英语
Original Document TypeArticle
WOS KeywordFACTOR XA INHIBITOR ; ORAL ANTICOAGULANTS ; STROKE ; PHARMACOKINETICS ; METAANALYSIS ; GENERATION ; PREVENTION ; SAFETY
AbstractBackgroundEdoxaban is a direct oral factor Xa inhibitor with proven antithrombotic effects. The long-term efficacy and safety of edoxaban as compared with warfarin in patients with atrial fibrillation is not known. MethodsWe conducted a randomized, double-blind, double-dummy trial comparing two once-daily regimens of edoxaban with warfarin in 21,105 patients with moderate-to-high-risk atrial fibrillation (median follow-up, 2.8 years). The primary efficacy end point was stroke or systemic embolism. Each edoxaban regimen was tested for noninferiority to warfarin during the treatment period. The principal safety end point was major bleeding. ResultsThe annualized rate of the primary end point during treatment was 1.50% with warfarin (median time in the therapeutic range, 68.4%), as compared with 1.18% with high-dose edoxaban (hazard ratio, 0.79; 97.5% confidence interval [CI], 0.63 to 0.99; P<0.001 for noninferiority) and 1.61% with low-dose edoxaban (hazard ratio, 1.07; 97.5% CI, 0.87 to 1.31; P=0.005 for noninferiority). In the intention-to-treat analysis, there was a trend favoring high-dose edoxaban versus warfarin (hazard ratio, 0.87; 97.5% CI, 0.73 to 1.04; P=0.08) and an unfavorable trend with low-dose edoxaban versus warfarin (hazard ratio, 1.13; 97.5% CI, 0.96 to 1.34; P=0.10). The annualized rate of major bleeding was 3.43% with warfarin versus 2.75% with high-dose edoxaban (hazard ratio, 0.80; 95% CI, 0.71 to 0.91; P<0.001) and 1.61% with low-dose edoxaban (hazard ratio, 0.47; 95% CI, 0.41 to 0.55; P<0.001). The corresponding annualized rates of death from cardiovascular causes were 3.17% versus 2.74% (hazard ratio, 0.86; 95% CI, 0.77 to 0.97; P=0.01), and 2.71% (hazard ratio, 0.85; 95% CI, 0.76 to 0.96; P=0.008), and the corresponding rates of the key secondary end point (a composite of stroke, systemic embolism, or death from cardiovascular causes) were 4.43% versus 3.85% (hazard ratio, 0.87; 95% CI, 0.78 to 0.96; P=0.005), and 4.23% (hazard ratio, 0.95; 95% CI, 0.86 to 1.05; P=0.32). ConclusionsBoth once-daily regimens of edoxaban were noninferior to warfarin with respect to the prevention of stroke or systemic embolism and were associated with significantly lower rates of bleeding and death from cardiovascular causes. (Funded by Daiichi Sankyo Pharma Development; ENGAGE AF-TIMI 48 ClinicalTrials.gov number, NCT00781391.)
Funding ProjectDaiichi Sankyo Pharma DevelopmentDaiichi Sankyo Company Limited; Daiichi SankyoDaiichi Sankyo Company Limited; Janssen PharmaceuticalsJohnson & JohnsonJohnson & Johnson USAJanssen Biotech Inc; MerckMerck & Company; Bristol-Myers SquibbBristol-Myers Squibb; Sanofi; Johnson JohnsonJohnson & JohnsonJohnson & Johnson USA; AstraZenecaAstraZeneca; Boehringer IngelheimBoehringer Ingelheim; GenzymeSanofi-AventisGenzyme Corporation; Amorcyte; Medicines Company; Cardiorentis; Eli LillyEli Lilly; MenariniMenarini Group; Medscape; Bayer HealthCareBayer AGBayer Healthcare Pharmaceuticals; GlaxoSmithKlineGlaxoSmithKline; Beckman Coulter; Roche Diagnostics; PfizerPfizer; EisaiEisai Co Ltd; Arena Pharmaceuticals; Aegerion; AngelMed; Xoma; ICON Clinical Research; Boston Clinical Research Institute; Ortho-McNeil-Janssen Pharmaceuticals; Biotronik; Boston ScientificBoston Scientific; MedtronicMedtronic; Cardio-Insight; ChanRx; Portola Pharmaceuticals; Janssen Scientific Affairs; Pozen; Coherex Medical; GileadGilead Sciences; Medical Research CouncilUK Research & Innovation (UKRI)Medical Research Council UK (MRC)European Commission [G0800777] Funding Source: researchfish; MRCUK Research & Innovation (UKRI)Medical Research Council UK (MRC) [G0800777] Funding Source: UKRI
PublisherMASSACHUSETTS MEDICAL SOC
Publication PlaceWALTHAM
ISSN0028-4793
EISSN1533-4406
Volume369Issue:22Pages:2093-2104
DOI10.1056/NEJMoa1310907
Page Number12
WOS SubjectMedicine, General & Internal
WOS Research AreaGeneral & Internal Medicine
WOS IDWOS:000327467500007
Indexed BySCIE
PubmedId24251359
ESI Hicited Paper2020-01 ; 2020-03 ; 2020-05 ; 2020-09 ; 2020-11 ; 2021-01 ; 2021-03 ; 2021-05 ; 2021-07 ; 2021-09 ; 2021-11 ; 2022-01 ; 2022-07 ; 2022-09 ; 2022-11 ; 2023-01 ; 2023-03 ; 2023-05 ; 2023-07 ; 2023-09 ; 2023-11
User Journal ClassificationT1类
Corresponding author address[Giugliano, Robert P.]Brigham & Womens Hosp, Div Cardiovasc Med, TIMI Study Grp, 350 Longwood Ave,1st Flr, Boston, MA 02115 USA.
Citation statistics
Cited Times:3067[WOS]   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
Identifierhttps://kms.wmu.edu.cn/handle/3ETUA0LF/20940
CollectionWenzhou Medical University First Affiliated Hospital
Corresponding AuthorGiugliano, Robert P.
Affiliation
1.Brigham & Womens Hosp, Boston, MA 02115 USA;
2.Harvard Univ, Sch Med, Boston, MA USA;
3.Mt Sinai Med Ctr, New York, NY 10029 USA;
4.Univ Hosp Case Med Ctr, Cleveland, OH USA;
5.Thomas Jefferson Med Coll, Philadelphia, PA USA;
6.McMaster Univ, Hamilton, ON, Canada;
7.Univ Hosp, Brno, Czech Republic;
8.Inst Cardiol, Warsaw, Poland;
9.Cardiol Res Ctr, Moscow 121552, Russia;
10.Osaka Natl Hosp, Natl Hosp Org, Osaka, Japan;
11.Quintiles, Durham, NC USA;
12.Daiichi Sankyo Pharma Dev, Edison, NJ USA;
13.Hosp Alta Complejidad Presidente Juan Domingo Per, Formosa, For, Argentina;
14.Corporac Med Gral San Martin SA, San Martin, Bue, Argentina;
15.Inst Cardiovasc San Luis, San Luis, Sls, Argentina;
16.Hosp Cordoba, Cordoba, Crd, Argentina;
17.Hosp Italiano Reg Sur, Bahia Blanca, Bue, Argentina;
18.Inst Invest Neurol Raul Carrea FLENI, Buenos Aires, Bue, Argentina;
19.Hosp Privado Ctr Med Cordoba, Cordoba, Crd, Argentina;
20.Hosp Prov Centenario, Rosario, Sfe, Argentina;
21.Cedir, Santa Fe, Sfe, Argentina;
22.Hosp Interzonal Gen Agudos Dr Jose Penna, Bahia Blanca, Bue, Argentina;
23.Sanatorio Nuestra Senora Rosario, San Salvador De Jujuy, Juj, Argentina;
24.Clin Coronel Suarez, Coronel Suarez, Bue, Argentina;
25.Hosp Italiano La Plata, La Plata, Argentina;
26.Hosp Cent Mendoza, Mendoza, Men, Argentina;
27.Clin Colombo, Cordoba, Crd, Argentina;
28.Inst Invest Clin Bahia Blanca, Bahia Blanca, Bue, Argentina;
29.Hosp San Bernardo, Salta, Sal, Argentina;
30.Cedim Clin Privada, Ramos Mejia, Bue, Argentina;
31.Ctr Salud Norte, Munro, Bue, Argentina;
32.STAT Res, Ciudad Autonoma De Bs As, Cba, Argentina;
33.Ctr Privado Tomografia Computada Cordoba SA, Cordoba, Crd, Argentina;
34.Sanatorio Carmen, Salta, Argentina;
35.Hosp Espanol Mendoza, Godoy Cruz, Men, Argentina;
36.Cemic Saavedra, Ciudad Autonoma De Bs As, Cba, Argentina;
37.Hosp Aleman, Ciudad Autonoma De Bs As, Cba, Argentina;
38.Inst Invest Clin San Nicolas, San Nicolas, Bue, Argentina;
39.Clin Privada Prov SA, Merlo Buenos Aires, Bue, Argentina;
40.Unidad Cardiol Clin, Mar Del Plata, Bue, Argentina;
41.Hosp Espanol, Buenos Aires, Cba, Argentina;
42.Hosp Jose Maria Ramos Mejia, Buenos Aires, Bue, Argentina;
43.Ctr Invest Clin Litoral SRL, Santa Fe, Sfe, Argentina;
44.Clin Chutro SRL, Cordoba, Crd, Argentina;
45.Hosp Gen Agudos Donac Francisco Santojanni, Buenos Aires, Cba, Argentina;
46.Azira Clin Res, Pergamino, Bue, Argentina;
47.ALPI Inst Rehabil Marcelo Fitte, Caba, Bue, Argentina;
48.Serv Hosp San Justo SA, Buenos Aires, Bue, Argentina;
49.Inst Invest Clin Rosario, Rosario, Sfe, Argentina;
50.Sanatorio Julio Corzo, Rosario, Sjn, Argentina;
51.Sanatorio Plaza, Rosario, Sfe, Argentina;
52.Inst Invest Clin Mar Plata, Mar Del Plata, Bue, Argentina;
53.Hosp Britanico Buenos Aires, Buenos Aires, Cba, Argentina;
54.Ctr Med Alcorta, Ciudad Autonoma De Bs As, Cba, Argentina;
55.Ctr Mod Cardiol, San Miguel De Tucuman, Tucuman, Argentina;
56.Clin Constituyentes, Moron, Bue, Argentina;
57.Sanatorio Britanico SA, Rosario, Sfe, Argentina;
58.Complejo Med PFA Churruca Vizca, Caba, Cba, Argentina;
59.Inst Cardiol Corrientes Juana Francisca Cabral, Corrientes, Cor, Argentina;
60.Inves Clin Tucuman, San Miguel De Tucuman, Tucuman, Argentina;
61.Clin Privada Caraffa, Cordoba, Crd, Argentina;
62.Clin & Maternidad Colon SA, Mar Del Plata, Bue, Argentina;
63.Inst Invest Clin Cipolletti, Cipolletti, Rio, Argentina;
64.Cordis Inst Corazon, Resistencia, Cha, Argentina;
65.Inst Med Cenesa, Salta, Sal, Argentina;
66.Inst Med Aguero, Moron, Bue, Argentina;
67.Clin Inst Med Adrogue, Almirante Brown, Bue, Argentina;
68.Clin Independencia, Munro, Bue, Argentina;
69.Sanatorio Guemes, Ciudad Autonoma De Bs As, Bue, Argentina;
70.Inst Invest Clin Zarate, Zarate, Bue, Argentina;
71.Royal Prince Alfred Hosp, Camperdown, NSW, Australia;
72.Lyell McEwin Hosp, Elizabeth Vale, SA, Australia;
73.Core Res Grp, Milton, Qld, Australia;
74.Cent Coast Neurosci Res, East Gosford, NSW, Australia;
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78.Geelong Hosp, Geelong, Vic, Australia;
79.Adelaide Med Res, Adelaide, SA, Australia;
80.Brisbane South Clin Res Ctr, Carina Heights, Qld, Australia;
81.Royal Perth Hosp, Perth, WA, Australia;
82.Joondalup Cardiovascular Trials Fdn, Joondalup, WA, Australia;
83.Peninsula Private Hosp, Frankston, Vic, Australia;
84.AZ Sint Lucas, Ghent, Belgium;
85.Sint Augustinusklin, Veurne, Belgium;
86.CHC Clin Esperance, Montegnee, Belgium;
87.UZ Leuven, Leuven, Belgium;
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90.Parque JeanLuc, Mouscron, Belgium;
91.Clin Univ St Luc, Brussels, Belgium;
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93.Acad Hosp St Jan, Brugge, Belgium;
94.AZ Jan Palfijn, Merksem, Belgium;
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97.ZNA Stuivenberg, Antwerp, Belgium;
98.Univ Fed Sao Paulo UNIFESP, Sao Paulo, SP, Brazil;
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100.SMO Brazil, Rio De Janeiro, RJ, Brazil;
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104.Hosp Clin Porto Alegre, Porto Alegre, RS, Brazil;
105.Univ Fed Pernambuco, Hosp Clin, Recife, PE, Brazil;
106.Hosp Cardiol Costantini, Curitiba, Parana, Brazil;
107.Inst Cardiol Santa Catarina, Sao Jose, SC, Brazil;
108.Hosp Sao Vicente de Paulo, Passo Fundo, RS, Brazil;
109.Inst Cardiol Rio Grande do Sul, Porto Alegre, RS, Brazil;
110.Hosp Estadual Mario Covas, Santo Andre, SP, Brazil;
111.Inst Cardiol Dist Fed, Brasilia, DF, Brazil;
112.Inst Pesquisa Estudos Multicentr, Caxias Do Sul, RS, Brazil;
113.Santa Casa de Misericordia Sao Paulo, Sao Paulo, SP, Brazil;
114.Clinicor Hosp Coracao Alagoas, Maceio, AL, Brazil;
115.Hosp Geral Bonsucesso, Rio De Janeiro, RJ, Brazil;
116.Hosp Mae Deus, Porto Alegre, RS, Brazil;
117.Santa Casa Misericordia Curitiba PUCPR, Curitiba, PR, Brazil;
118.CCBR Brasil, Rio De Janeiro, RJ, Brazil;
119.Hosp Sao Lucas PUCRS, Porto Alegre, RS, Brazil;
120.Via Med Ctr Clin, Goiania, Go, Brazil;
121.Santa Casa Porto Alegre, Porto Alegre, RS, Brazil;
122.Hosp Serv Publ Estadual Sao Paulo, Sao Paulo, SP, Brazil;
123.Santa Casa Misericordia Belo Horizonte, Belo Horizonte, MG, Brazil;
124.Hosp Bruno Born, Lajeado, RS, Brazil;
125.Hosp Ctr Med Campinas, Campinas, SP, Brazil;
126.Encore Cardiol & Radiol Intervencionista, Aparecida De Goiania, Go, Brazil;
127.ICM Inst Coracao Marilia, Marilia, SP, Brazil;
128.Loema Inst Pesquisa Clin, Campinas, SP, Brazil;
129.Inst Coracao Incor, Sao Paulo, SP, Brazil;
130.Hosp & Maternidade Dr Celso Pierro PUC Campinas, Campinas, SP, Brazil;
131.Hosp Clin FMRP, Ribeirao Preto, SP, Brazil;
132.PS Cardiol Pernambuco PROCAPE Univ Pernambuco, Recife, PE, Brazil;
133.Hosp Espanhol, Salvador, BA, Brazil;
134.Clin Procardio, Blumenau, SC, Brazil;
135.MHAT Plovdiv AD, Plovdiv, Bulgaria;
136.UMHAT Alexandrovska EAD, Sofia, Bulgaria;
137.MHAT Natl Heart Hosp EAD, Sofia, Bulgaria;
138.UMHAT Tzaritza Yoanna ISUL EAD, Sofia, Bulgaria;
139.MHAT Ruse AD, Ruse, Bulgaria;
140.MHAT Haskovo AD, Haskovo, Bulgaria;
141.MHAT Sveta Ekaterina EOOD, Dimitrovgrad, Bulgaria;
142.UNMTHAT Tzar Boris III Sofia, Sofia, Bulgaria;
143.UMHAT Sv Georgi EAD, Plovdiv, Bulgaria;
144.Fourth MHAT Sofia AD, Sofia, Bulgaria;
145.MHAT Burgas AD, Burgas, Bulgaria;
146.Diagnost Consultat Ctr Sveti Georgi EOOD, Haskovo, Bulgaria;
147.Cent Clin Base, Med Inst MI, Sofia, Bulgaria;
148.Second MHAT Sofia AD, Sofia, Bulgaria;
149.DCC Chaika EOOD, Varna, Bulgaria;
150.UMHAT Dr Georgi Stranski EAD, Pleven, Bulgaria;
151.Pharmaceut Integrated Res Co, Halifax, NS, Canada;
152.Heart Care Res, Oshawa, ON, Canada;
153.Dr S Bose Med Profess Corp, North Saskatoon, SK, Canada;
154.Oshawa Med Arts Bldg, Oshawa, ON, Canada;
155.Sarnia Res Inst, Sarnia, ON, Canada;
156.Penticton Reg Hosp, Penticton, BC, Canada;
157.Clin Sante Cardio MC, Montreal, PQ, Canada;
158.Hop Pierre Le Gardeur, CSSS Sud Lanaudiere, Terrebonne, PQ, Canada;
159.CHUM Hotel Dieu, Montreal, PQ, Canada;
160.Med Arts Hlth Res Grp, Kamloops, BC, Canada;
161.Trainyards Hlth & Wellness Ctr, Ottawa, ON, Canada;
162.Hamilton Gen Hosp, Hamilton, ON, Canada;
163.Neufort Inc, St Lambert, PQ, Canada;
164.Univ Ottawa, Heart Inst, Ottawa, ON, Canada;
165.Pharmaceut Integrated Res Co, Bridgewater, NS, Canada;
166.Alder Med Ctr, Campbell River, BC, Canada;
167.Discovery Clin Serv Ltd, Victoria, BC, Canada;
168.Montreal Gen Hosp, Montreal, PQ, Canada;
169.Ctr Hosp Reg Lanaudiere, St Charles Borromee, PQ, Canada;
170.Dr R Labonte Profess Med Corp, Sudbury, ON, Canada;
171.Ctr Investigat Clin Mauricie, Trois Rivieres, PQ, Canada;
172.Calgary West Med Ctr, Calgary, AB, Canada;
173.Med Arts Hlth Res Grp, Kelowna, BC, Canada;
174.Heart Hlth Inst, Calgary, AB, Canada;
175.Eastern Hlth, St John, NF, Canada;
176.Medicor Res Inc, Sudbury, ON, Canada;
177.Cardiol & Res, Westmount, PQ, Canada;
178.Pharmaceut Integrated Res Co, London, ON, Canada;
179.Beamsville Med Ctr, Beamville, ON, Canada;
180.Trainyards Hlth & Wellness Ctr, Ottawa, ON, Canada;
181.PIRC Res Off Brampton, Brampton, ON, Canada;
182.Pharmaceut Integrated Res Co, Kitchener, ON, Canada;
183.Quebec Heart Inst, Quebec City, PQ, Canada;
184.Corunna Med Res Ctr, Corunna, ON, Canada;
185.Queen Elizabeth 2 Hlth Sci Ctr, Halifax, NS, Canada;
186.Rech Medicale St Jerome Inc, St Jerome, PQ, Canada;
187.Kelowna Cardiol Res, Kelowna, BC, Canada;
188.PIRC Res Off Brampton, Listowel, ON, Canada;
189.Scarborough Cardiol Res, Scarborough, ON, Canada;
190.Fraser Clinical Trials Inc, New Westminster, BC, Canada;
191.Gain Med Ctr, Coquitlam, BC, Canada;
192.Ctr Hosp Beauce Etchemin, St Georges, PQ, Canada;
193.GS Cardiac Lab Med Professional Corp, Sudbury, ON, Canada;
194.Montreal Heart Inst, Montreal, PQ, Canada;
195.Ctr Rech Clin Quebec, Quebec City, PQ, Canada;
196.JJ Dig Res, Toronto, ON, Canada;
197.Holley Clin, Quesnel, BC, Canada;
198.Dorchester Med Ctr, Dorchester, ON, Canada;
199.Wharton Med Clin Clin Trials, Hamilton, ON, Canada;
200.Pharmaceut Integrated Res Co, Liverpool, NS, Canada;
201.Victoria Hosp, Victoria, Chile;
202.Hosp San Juan Dios Serena, La Serena, Chile;
203.Hosp El Pino, Santiago, Chile;
204.Pontificia Univ Catolica Chile, Hosp Clin, Santiago, Chile;
205.Hosp Salvador, Santiago, Chile;
206.Hosp San Borja Arriaran, Santiago, Chile;
207.Hosp Reg Rancagua, Rancagua, Chile;
208.Clin Iquique, Iquique, Chile;
209.Hosp Naval Almirante Nef, Vina del Mar, Chile;
210.Ctr Investigac Clin, Temuco, Chile;
211.Corporac Beneficencia Osorno, Osorno, Chile;
212.Hosp Dr Sotero del Rio, Santiago, Chile;
213.Hosp Dr Hernan Henriquez Aravena, Temuco, Chile;
214.Hosp Barros Luco, Santiago, Chile;
215.Lanzhou Univ, Hosp 2, Lanzhou, Peoples R China;
216.Zhejiang Univ, Affiliated Hosp Coll Med 1, Hangzhou, Peoples R China;
217.Sichuan Univ, West China Hosp, Chengdu, Peoples R China;
218.Sun Yat sen Univ, Affiliated Hosp 1, Guangzhou, Peoples R China;
219.Zhejiang Univ, Sch Med, Sir Run Run Shaw Hosp, Hangzhou, Peoples R China;
220.Nanchang Univ, Affiliated Hosp 2, Nanchang, Jiangxi, Peoples R China;
221.Renmin Hosp Jiang Xi Prov, Nanchang, Jiangxi, Peoples R China;
222.Ren Min Hosp Wu Han Univ, Wuhan, Peoples R China;
223.Guangxi Med Univ, Affiliated Hosp 1, Nanning, Peoples R China;
224.Hainan Med Coll, Affiliated Hosp, Haikou, Hainan, Peoples R China;
225.Harbin Med Univ, Affiliated Hosp 1, Harbin, Peoples R China;
226.Peoples Hosp Liaoning Prov, Shenyang, Peoples R China;
227.Second Mil Med Univ, Changzheng Hosp, Shanghai, Peoples R China;
228.Peoples Hosp Guangxi Zhuang Autonomous Region, Nanning, Peoples R China;
229.China Med Univ, Shengjing Hosp, Shenyang, Peoples R China;
230.Bethune Int Peace Hosp, Shijiazhuang, Hebei, Peoples R China;
231.Liaoning Med Coll, Hosp Affiliated 1, Jinzhou, Peoples R China;
232.Shanghai 6 Peoples Hosp, Shanghai, Peoples R China;
233.Guangdong Prov Peoples Hosp, Guangzhou, Peoples R China;
234.Tongji Univ, Tong Ji Hosp, Shanghai, Peoples R China;
235.Tianjin Med Univ, Hosp 2, Tianjin, Peoples R China;
236.Cent South Univ, Xiangya Hosp 3, Changsha, Peoples R China;
237.Chinese Acad Med Sci, Cardiovascular Inst, Fuwai Hosp, Beijing, Peoples R China;
238.Jilin Univ, Hosp 1, Changchun, Peoples R China;
239.Chongqing Med Univ, Affiliated Hosp 2, Chongqing, Peoples R China;
240.Harbin Med Univ, Affiliated Hosp 2, Harbin, Peoples R China;
241.Xian Med Univ, Hosp Affiliated 1, Xian, Peoples R China;
242.Wenzhou Med Coll, Affiliated Hosp 1, Wenzhou, Peoples R China;
243.Lanzhou Univ, Hosp Affiliated 1, Lanzhou, Peoples R China;
244.Baotou Cent Hosp, Baotou, Peoples R China;
245.Capital Med Univ, Beijing Tong Ren Hosp Affiliated, Beijing, Peoples R China;
246.NanChang Univ, Affiliated Hosp 1, Nanchang, Jiangxi, Peoples R China;
247.Zhongshan Univ, Affiliated Hosp 2, Guangzhou, Peoples R China;
248.Consultorio Privado Jose Luis Accini, Baranquilla, Colombia;
249.Hosp Santa Sofia, Manizales, Colombia;
250.Inst Corbic, Medellin, Colombia;
251.Clin Cardiovascular Santa Maria, Medellin, Colombia;
252.Inst Corazon Bucaramanga, Bucaramanga, Colombia;
253.Promotora Medica Amer SA, Medellin, Colombia;
254.Ctr Diagnostico Cardiologico Ltda, Cartagena, Colombia;
255.Fdn Ctr Investigac Clin CIC, Medellin, Colombia;
256.Foqus LTDA, Bogota Cundinamarca, Colombia;
257.Fdn Caribe Investigac Biomed, Barranquilla, Colombia;
258.Ctr Estudios Clin Quindio, Armenia, Colombia;
259.Clin Hosp Ctr Split, Split, Croatia;
260.Gen Hosp Varazdin, Varazhdin, Croatia;
261.Special Hosp Med Rehabil, Krapinske Toplice, Croatia;
262.Gen Hosp Dubrovnik, Dubrovik, Croatia;
263.Univ Hosp Ctr Zagreb, Zagreb, Croatia;
264.Gen Hosp Karlovac, Karlovac, Croatia;
265.Gen Hosp Zadar, Zadar, Croatia;
266.Gen Hosp Dr J Bencev, Slavonski Brod, Croatia;
267.Clin Hosp Osijek, Osijek, Croatia;
268.Gen Hosp Dr Tomislav Bardek, Koprivn, Croatia;
269.Univ Hosp Dubrava, Zagreb, Croatia;
270.Neurologicka ambulance Bormed, Ostrava Trebovice, Czech Republic;
271.Ordinace pro choroby srdce cev, Jindrichuv Hradec, Czech Republic;
272.Fakultni nemocnice Hradec Kralove, Hradec Kralove, Czech Republic;
273.Poliklinika Humanitas, Bilovec, Czech Republic;
274.Nemocnice Slany, Slany, Czech Republic;
275.Kardiologicka ordinace, Brno, Czech Republic;
276.Interni ambulance, Trutnov, Czech Republic;
277.Nemocnice Cesky Krumlov, Cesky Krumlov, Czech Republic;
278.Kromerizska nemocnice as, Kromeriz, Czech Republic;
279.Kardiol, Revnice, Czech Republic;
280.Fakultni nemocnice Kralovske Vinohrady, Prague, Czech Republic;
281.Kardiologicka interni ambulance, Prague 1, Czech Republic;
282.Interni ambulance, Chrudim, Czech Republic;
283.Oblastni nemocnice Nachod, Nachod, Czech Republic;
284.Ustredni vojenska nemocnice Praha, Prague 6, Czech Republic;
285.Nemocnice Hranice as, Hranice, Czech Republic;
286.Poliklinika RAVAK, Pribram 8, Czech Republic;
287.Poliklinika Malesice, Prague 10, Czech Republic;
288.Mediscan sro, Prague 11, Czech Republic;
289.Interni ordinace, Teplice, Czech Republic;
290.Kardiologicka ambulance, Mlada Boleslav, Czech Republic;
291.Poliklinika Modrany, Prague 4, Czech Republic;
292.INNEra sro, Benesov, Czech Republic;
293.Kardiologicka ambulance, Prague 10, Czech Republic;
294.Privatni interni ambulance, Brno, Czech Republic;
295.InterKardioML sro, Marianske Lazne, Czech Republic;
296.Interni ambulance, Pardubice, Czech Republic;
297.Nemocnice s poliklinikou Semily, Semily, Czech Republic;
298.Gen practitioner sro, Ostrava, Czech Republic;
299.Nemocnice Havlickuv Brod po, Havlickuv Brod, Czech Republic;
300.Kardiologicka ambulance, Usti Nad Labem, Czech Republic;
301.Kardiologicka ambulance, Hradec Kralove, Czech Republic;
302.Interni ambulance, Prague 6, Czech Republic;
303.Krajska zdravotni as Nemocnice Teplice po, Teplice, Czech Republic;
304.Oblastni nemocnice Kolin, Kolin, Czech Republic;
305.Nemocnice Na Frantisku, Prague 1, Czech Republic;
306.FN Brno Bohunice, Brno, Czech Republic;
307.Kardiologicka ordinace, Pardubice, Czech Republic;
308.Ordinace interniho Iekarstvi, Prague 5, Czech Republic;
309.Horsens Sygehus, Horsens, Denmark;
310.Bispebjerg Hosp, Kobenhavn NV, Denmark;
311.Rigshospitalet, Kobenhavn O, Denmark;
312.Holbaek Sygehus, Holbaek, Denmark;
313.Glostrup Cty Hosp, Glostrup, Denmark;
314.Bispebjerg Hosp, Kobenhavn NV, Denmark;
315.Herlev Hosp, Herlev, Denmark;
316.Frederiksberg Univ Hosp, Frederiksberg, Denmark;
317.Sydvestjyds Sygehus Esbjerg, Esbjerg, Denmark;
318.Gentofte Univ Hosp, Hellerup, Denmark;
319.Skejby Sygehus Aarhus University Hosp, Aarhus, Denmark;
320.Fertilitas AS, Haabneeme, Estonia;
321.Tartu Univ Hosp, Tartu, Estonia;
322.Orthopaed & Clin Res Ctr, Tartu, Estonia;
323.North Estonia Med Ctr Fdn, Tallinn, Estonia;
324.Parnu Hosp, Parnu, Estonia;
325.Oulun yliopistollinen sairaala, Oulu, Finland;
326.EtelaKarjalan keskussairaala, Lappeenranta, Finland;
327.Ita Suomen yliopisto Kuop kampus Kliininen tutkim, Kuopio, Finland;
328.Seinajoen keskussairaala, Seinajoki, Finland;
329.Keski Suomen keskussairaala, Jyvaskyla, Finland;
330.Terveystalo Tampere, Tampere, Finland;
331.Finn Medi 1, Tampere, Finland;
332.Hop Europeen Georges Pompidou, Paris, France;
333.Ctr Hosp Gen, Valenciennes 59, France;
334.Hop Bichat Claude Bernard, Paris 75, France;
335.Hop Trousseau, Tours 37, France;
336.Ctr Hosp Cambrai, Cambrai 59, France;
337.Hop Instruct Armees Percy, Clamart 92, France;
338.Chu Brest Hop Cavale Blanche, Brest 29, France;
339.Chu Poitiers Hop Miletrie, Poitiers 86, France;
340.CH Chatiliez Tourcoing, Tourcoing 59, France;
341.Hop Antoine Beclere, Clamart 92, France;
342.Ctr Hosp Sud, Amiens 80, France;
343.Hosp Cardiolog Chru Lille, Lille 59, France;
344.Ctr Hosp Abbeville, Abbeville 80, France;
345.Hop Haut Eveque Cardiol, Pessac 33, France;
346.Kardiolog Praxis, Wermsdorf, SN, Germany;
347.Univ Ulm Klinikum, Ulm, BW, Germany;
348.Klinikum Altenburger Land, Altenburg, TH, Germany;
349.Univ Klinikum Dresden, Dresden, SN, Germany;
350.Kardiol Praxen Spreebogen, Berlin, BE, Germany;
351.Synexus ClinPharm Int GmbH, Frankfurt, HE, Germany;
352.Synexus ClinPharm Int GmbH, Leipzig, SN, Germany;
353.Gemeinschaftspraxis, Stuhr, HB, Germany;
354.Hausarztzentrum, Essen, NW, Germany;
355.Pro Scientia Med, Lubeck, SH, Germany;
356.Orgamed Syst Fuchs & Partner KG, Giengen, BW, Germany;
357.Clin Res Hamburg GmbH, Hamburg, HH, Germany;
358.Klinikum St Georg Leipzig, Leipzig, SN, Germany;
359.St Johannes Hosp PS, Dortmund, NW, Germany;
360.Univ Klinikum Mannheim, Mannheim, BW, Germany;
361.Vivantes Klinikum Friedrichshain, Berlin, BE, Germany;
362.Evangel Krankenhaus, Witten, NW, Germany;
363.Kardiol Praxis, Bad Homburg, HE, Germany;
364.Gemeinschaftspraxis Kleinecke Pohl Kirsch Benner, Cologne, NW, Germany;
365.Synexus Clin Res GmbH, Berlin, BE, Germany;
366.Synexus ClinPharm Int GmbH, Potsdam, BR, Germany;
367.Synexus Clin Res GmbH, Dresden, SN, Germany;
368.St Josefs Hosp, Cloppenburg, NI, Germany;
369.Innomed Leipzig GmbH, Leipzig, SN, Germany;
370.Synexus ClinPharm Int GmbH, Magdeburg, ST, Germany;
371.Mare Klinikum, Kiel, SH, Germany;
372.Kerckhoff Klin GmbH, Bad Nauheim, HE, Germany;
373.St Josef Hosp PS, Bochum, NW, Germany;
374.Gemeinschaftspraxis Drs Krohn Mueller Glamann, Hamburg, HH, Germany;
375.Synexus ClinPharm Int GmbH, Goerlitz, SN, Germany;
376.Gemeinschaftspraxis Dr Al Nakkash Dr Pohl Dr C Po, Dresden, SN, Germany;
377.Gemeinschaftspraxis, Nienburg, NI, Germany;
378.Internist Praxis, Augsburg, BY, Germany;
379.Synexus ClinPharm Int GmbH, Bochum, NW, Germany;
380.Staedt Klinikum Dresden Friedrichstadt, Dresden, SN, Germany;
381.Klin Forsch Berlin, Berlin, BE, Germany;
382.Internist Praxisgemeinschaft, Weyhe, NI, Germany;
383.Ludwig Maximilians Univ Munchen, Munich, BY, Germany;
384.Facharztzentrum Dresden Neustadt GBR, Dresden, SN, Germany;
385.Kardiologische Praxis, Bad Homburg, HE, Germany;
386.Univ Klinikum Heidelberg, Heidelberg, BW, Germany;
387.DRK Kliniken Berlin Westend, Berlin, BE, Germany;
388.ClinPhenomics GmbH & Co KG, Frankfurt, HE, Germany;
389.Patras Univ Hosp, Patras, Greece;
390.Gen Prefectural Hosp Trikala, Trikala, Greece;
391.Gen Hosp Larissa, Larisa, Greece;
392.Gen Hosp Athens Asklipio Voulas, Athens, Greece;
393.Gen Hosp Rhodes, Rhodes, Greece;
394.Gen Hosp Athens G Gennimatas, Athens, Greece;
395.Edificio Plaza Dorada, Guatemala City, Guatemala;
396.Liga Corazon, Guatemala City, Guatemala;
397.Clin Privada Dr Rodas Estrada, Guatemala City, Guatemala;
398.CardioQuetzal, Quetzaltenango, Guatemala;
399.Clin Hosp Ctr Med, Guatemala City, Guatemala;
400.Unicar, Guatemala City, Guatemala;
401.Josa Andras Oktatokorhaz Egeszsegugyi Szolg Nonpr, Nyiregyhaza, Hungary;
402.Debreceni Egyet Orvos Egeszsegtudomanyi Centrum, Debrecen, Hungary;
403.Sopron Med SMO Erzsebet Korhaz, Sopron, Hungary;
404.UNO Med Trials Kft, Budapest, Hungary;
405.Tolna Megyei Onkormanyzat Balassa Janos Korhaza, Szekszard, Hungary;
406.Honvedelmi Miniszterium Allami Egeszsegugyi Kozpo, Budapest, Hungary;
407.Vas Megyei Markusovszky Korhaz Nonprofit Zrt, Szombathely, Hungary;
408.Bajai Szent Rokus Korhaz, Baja, Hungary;
409.Zala Megyei Korhaz, Zalaegerszeg, Hungary;
410.Kanizsai Dorottya Korhaz, Nagykanizsa, Hungary;
411.Pest Megyei Flor Ferenc Korhaz, Kistarcsa, Hungary;
412.Semmelweis Egyet, Budapest, Hungary;
413.Bacs Kiskun Megyei Onkormanyzat Korhaza, Kecskemet, Hungary;
414.Erzsebet Korhaz Rendelointezet, Hodmezovasarhely, Hungary;
415.Magyar Imre Korhaz, Ajka, Hungary;
416.Pecsi Tudomanyegyetem Altalanos Orvostudomanyi Ka, Pecs, Hungary;
417.Rethy Pal Korhaz, Bekescsaba, Hungary;
418.Selye Janos Korhaz, Komarom, Hungary;
419.Budai Irgalmasrendi Korhaz, Budapest, Hungary;
420.Fov Onk Egyesitett Szt Istvan & Szt Laszlo Korh R, Budapest, Hungary;
421.Sheth Vadilal Sarabhai Hosp & Municipal Med Colle, Ahmadabad, Gujarat, India;
422.NH Lissie Hosp, Cochin, Kerala, India;
423.SP Med Coll Associated Grp Hosp, Bikaner, Rajasthan, India;
424.Arneja Heart Inst, Nagpur, Maharashtra, India;
425.Max Devki Devi Heart & Vasc Inst, New Delhi, Delhi, India;
426.Yashoda Hosp, Hyderabad, Andhra Pradesh, India;
427.Dr Ramesh Cardiac & Multi Special Hosp Ltd, Vijayawada, Andhra Pradesh, India;
428.Medwin Hosp, Hyderabad, Andhra Pradesh, India;
429.Bankers Heart Inst, Vadodara, Gujarat, India;
430.Krishna Hosp & ICU, Aurangabad, Maharashtra, India;
431.MGM Med Coll & MY Hosp, Indore, Madhya Pradesh, India
Recommended Citation
GB/T 7714
Giugliano, Robert P.,Ruff, Christian T.,Braunwald, Eugene,et al. Edoxaban versus Warfarin in Patients with Atrial Fibrillation[J]. NEW ENGLAND JOURNAL OF MEDICINE,2013,369(22):2093-2104.
APA Giugliano, Robert P.., Ruff, Christian T.., Braunwald, Eugene., Murphy, Sabina A.., Wiviott, Stephen D.., ... & Jones,. (2013). Edoxaban versus Warfarin in Patients with Atrial Fibrillation. NEW ENGLAND JOURNAL OF MEDICINE, 369(22), 2093-2104.
MLA Giugliano, Robert P.,et al."Edoxaban versus Warfarin in Patients with Atrial Fibrillation".NEW ENGLAND JOURNAL OF MEDICINE 369.22(2013):2093-2104.

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