Expression of GPX4 by oncolytic vaccinia virus can significantly enhance CD8+T cell function and its impact against pancreatic ductal adenocarcinoma

doi:10.1080/2162402X.2024.2322173

科研成果详情

题名	Expression of GPX4 by oncolytic vaccinia virus can significantly enhance CD8+T cell function and its impact against pancreatic ductal adenocarcinoma
作者	Wei, Wei 1; Tian, Linqing 2; Zheng, Xiaoyan 3; Zhong, Lei 4; Chen, Yuan 5; Dong, Hui 6; Zhang, Guibing 7; Wang, Shibing 8; Tong, Xiangmin 9
发表期刊	ONCOIMMUNOLOGY 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Glutathione peroxide 4 oncolytic vaccinia virus pancreatic ductal adenocarcinoma tumor microenvironment
其他关键词	T-CELLS ; LIPID-PEROXIDATION ; EFFECTOR FUNCTION ; FERROPTOSIS ; VIROTHERAPY ; ANTIBODY ; CARRIERS
摘要	Pancreatic ductal adenocarcinoma (PDAC) is currently difficult to treat, even when therapies are combined with immune checkpoint blockade (ICB). A novel strategy for immunotherapy would be to maximize the therapeutic potential of oncolytic viruses (OVs), which have been proven to engage the regulation of tumor microenvironment (TME) and cause-specific T-cell responses. To boost tumor sensitivity to ICB therapy, this study aimed to investigate how glutathione peroxide 4 (GPX4)-loaded OVs affect CD8(+) T cells and repair the immunosuppressive environment. Here, we successfully constructed a novel recombinant oncolytic vaccinia virus (OVV) encoding the mouse GPX4 gene. We found the OVV-GPX4 effectively replicated in tumor cells and prompted the expression of GPX4 in T cells. Our research indicated that OVV-GPX4 could reshape the TME, rectify the depletion of CD8(+)T cells, and enhance the antitumor effects of ICB therapy.
资助项目	Foundation of Science Technology Department of Zhejiang Province [LGF22H080012, LGF22H080008]; Zhejiang Provincial Medical Technology Plan Project [2022KY505, 2020KY052]
出版者	TAYLOR & FRANCIS INC
ISSN	2162-402X
EISSN	2162-402X
卷号	13 期号:1
DOI	10.1080/2162402X.2024.2322173
页数	14
WOS类目	Oncology ; Immunology
WOS研究方向	Oncology ; Immunology
WOS记录号	WOS:001177495100001
收录类别	SCIE ; PUBMED ; SCOPUS
发表日期	2024-12-31
URL	查看原文
Pubmed记录号	38419758
Scopus记录号	2-s2.0-85186216570
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/209373
专题	其他_温州医科大学附属衢州医院
通讯作者	Wang, Shibing; Tong, Xiangmin
作者单位	1.Jinzhou Med Univ, Affiliated Peoples Hosp, Hangzhou Med Coll, Zhejiang Prov Peoples Hosp,Postgrad Training Base, Hangzhou, Zhejiang, Peoples R China; 2.Bengbu Med Coll, Dept Clin Med, Bengbu, Peoples R China; 3.Wenzhou Med Univ, Quzhou Peoples Hosp, Dept Lab Med, Quzhou Affiliated Hosp, Quzhou, Zhejiang, Peoples R China; 4.Tongxiang Tradit Chinese Med Hosp, Dept Lab Med, Tongxiang, Zhejiang, Peoples R China; 5.Zhejiang Prov Peoples Hosp, Affiliated Peoples Hosp, Hangzhou Med Coll, Dept Pathol, Hangzhou, Zhejiang, Peoples R China; 6.Punan Hosp Pudong New Dist, Dept Stomatol, Shanghai, Peoples R China; 7.Hangzhou Fuyang First Peoples Hosp, Dept Hematol, Hangzhou, Zhejiang, Peoples R China; 8.Zhejiang Prov Peoples Hosp, Hangzhou Med Coll, Canc Ctr, Dept Pathol,Affiliated Peoples Hosp, Hangzhou 310014, Zhejiang, Peoples R China; 9.Zhejiang Univ, Affiliated Hangzhou Peoples Hosp 1, Dept Clin Res Ctr, Sch Med,Key Lab Integrated Oncol & Intelligent Med, Hangzhou 310006, Zhejiang, Peoples R China
推荐引用方式 GB/T 7714	Wei, Wei,Tian, Linqing,Zheng, Xiaoyan,et al. Expression of GPX4 by oncolytic vaccinia virus can significantly enhance CD8+T cell function and its impact against pancreatic ductal adenocarcinoma[J]. ONCOIMMUNOLOGY,2024,13(1).
APA	Wei, Wei., Tian, Linqing., Zheng, Xiaoyan., Zhong, Lei., Chen, Yuan., ... & Tong, Xiangmin. (2024). Expression of GPX4 by oncolytic vaccinia virus can significantly enhance CD8+T cell function and its impact against pancreatic ductal adenocarcinoma. ONCOIMMUNOLOGY, 13(1).
MLA	Wei, Wei,et al."Expression of GPX4 by oncolytic vaccinia virus can significantly enhance CD8+T cell function and its impact against pancreatic ductal adenocarcinoma".ONCOIMMUNOLOGY 13.1(2024).