科研成果详情

题名Male Oxidative Stress Infertility (MOSI): Proposed Terminology and Clinical Practice Guidelines for Management of Idiopathic Male Infertility
作者
Agarwal, Ashok1,2; Parekh, Neel2; Selvam, Manesh Kumar Panner1,2; Henkel, Ralf1,3; Shah, Rupin4; Homa, Sheryl T.5; Ramasamy, Ranjith6; Ko, Edmund7; Tremellen, Kelton8; Esteves, Sandro9,10; Majzoub, Ahmad1,11; Alvarez, Juan G.12,94; Gardner, David K.13; Jayasena, Channa N.14,15; Ramsay, Jonathan W.15; Cho, Chak-Lam16; Saleh, Ramadan17; Sakkas, Denny18; Hotaling, James M.19; Lundy, Scott D.2; Vij, Sarah2; Marmar, Joel20; Gosalvez, Jaime21; Sabanegh, Edmund2; Park, Hyun Jun22,23; Zini, Armand24; Kavoussi, Parviz25; Micic, Sava26; Smith, Ryan27; Busetto, Gian Maria28; Bakircioǧlu, Mustafa Emre29; Haidl, Gerhard30; Balercia, Giancarlo31; Puchalt, Nicolás Garrido32; Ben-Khalifa, Moncef33; Tadros, Nicholas34; Kirkman-Browne, Jackson35,36; Moskovtsev, Sergey37; Huang, Xuefeng38; Borges, Edson39; Franken, Daniel40; Bar-Chama, Natan41; Morimoto, Yoshiharu42; Tomita, Kazuhisa42; Srini, Vasan Satya43; Ombelet, Willem44,45; Baldi, Elisabetta46; Muratori, Monica47; Yumura, Yasushi48; Vignera, Sandro La49; Kosgi, Raghavender50; Martinez, Marlon P.51; Evenson, Donald P.52; Zylbersztejn, Daniel Suslik53; Roque, Matheus54; Cocuzza, Marcello55; Vieira, Marcelo56,57; Ben-Meir, Assaf58; Orvieto, Raoul59,60; Levitas, Eliahu61; Wiser, Amir62,63; Arafa, Mohamed64; Malhotra, Vineet65; Parekattil, Sijo Joseph66,67; Elbardisi, Haitham64; Carvalho, Luiz68,69; Dada, Rima70; Sifer, Christophe71; Talwar, Pankaj72; Gudeloglu, Ahmet73; Mahmoud, Ahmed M.A.74; Terras, Khaled75; Yazbeck, Chadi76; Nebojsa, Bojanic77; Durairajanayagam, Damayanthi78; Mounir, Ajina79; Kahn, Linda G.80; Baskaran, Saradha1; Pai, Rishma Dhillon81; Paoli, Donatella82; Leisegang, Kristian83; Moein, Mohamed-Reza84; Malik, Sonia85; Yaman, Onder86; Samanta, Luna87; Bayane, Fouad88; Jindal, Sunil K.89; Kendirci, Muammer90; Altay, Baris91; Perovic, Dragoljub92; Harlev, Avi93
发表日期2019-09
发表期刊WORLD JOURNAL OF MENS HEALTH   影响因子和分区
语种英语
原始文献类型Review
关键词Infertility, male MOSI Oxidation reduction potential Oxidative stress Semen
其他关键词SPERM DNA FRAGMENTATION ; DOUBLE-BLIND ; SEMINAL PLASMA ; HUMAN SEMEN ; MALE-FERTILITY ; SUPEROXIDE-DISMUTASE ; GLUTATHIONE THERAPY ; MALE REPRODUCTION ; CONTROLLED-TRIAL ; MEDICAL THERAPY
摘要Despite advances in the field of male reproductive health, idiopathic male infertility, in which a man has altered semen characteristics without an identifiable cause and there is no female factor infertility, remains a challenging condition to diagnose and manage. Increasing evidence suggests that oxidative stress (OS) plays an independent role in the etiology of male infertility, with 30% to 80% of infertile men having elevated seminal reactive oxygen species levels. OS can negatively affect fertility via a number of pathways, including interference with capacitation and possible damage to sperm membrane and DNA, which may impair the sperm's potential to fertilize an egg and develop into a healthy embryo. Adequate evaluation of male reproductive potential should therefore include an assessment of sperm OS. We propose the term Male Oxidative Stress Infertility, or MOSI, as a novel descriptor for infertile men with abnormal semen characteristics and OS, including many patients who were previously classified as having idiopathic male infertility. Oxidation-reduction potential (ORP) can be a useful clinical biomarker for the classification of MOSI, as it takes into account the levels of both oxidants and reductants (antioxidants). Current treatment protocols for OS, including the use of antioxidants, are not evidence-based and have the potential for complications and increased healthcare-related expenditures. Utilizing an easy, reproducible, and cost-effective test to measure ORP may provide a more targeted, reliable approach for administering antioxidant therapy while minimizing the risk of antioxidant overdose. With the increasing awareness and understanding of MOSI as a distinct male infertility diagnosis, future research endeavors can facilitate the development of evidence-based treatments that target its underlying cause.
资助项目American Center for Reproductive Medicine; NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCESUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of Environmental Health Sciences (NIEHS) [K99ES030403] Funding Source: NIH RePORTER
出版者KOREAN SOC SEXUAL MEDICINE & ANDROLOGY
出版地GWANGJU
ISSN2287-4208
EISSN2287-4690
卷号37期号:3页码:296-312
DOI10.5534/wjmh.190055
页数17
WOS类目Andrology ; Health Care Sciences & Services ; Urology & Nephrology
WOS研究方向Endocrinology & Metabolism ; Health Care Sciences & Services ; Urology & Nephrology
WOS记录号WOS:000482196700006
收录类别SCIE ; PUBMED ; SCOPUS
URL查看原文
PubMed ID31081299
PMC记录号PMC6704307
SCOPUSEID2-s2.0-85073335150
ESI高被引论文2020-09 ; 2020-11 ; 2021-01 ; 2021-03 ; 2021-05 ; 2021-07 ; 2021-11 ; 2022-01 ; 2022-03 ; 2022-07 ; 2022-09 ; 2022-11 ; 2023-01 ; 2023-03 ; 2023-05 ; 2023-07 ; 2023-09 ; 2023-11 ; 2024-01 ; 2024-03 ; 2024-05 ; 2024-07
通讯作者地址[Agarwal, Ashok]American Center for Reproductive Medicine,Cleveland Clinic,Mail Code X-11, 10681 Carnegie Avenue,Cleveland,44195,United States
Scopus学科分类Reproductive Medicine;Aging;Health Policy;Public Health, Environmental and Occupational Health;Psychiatry and Mental Health;Urology;Pharmacology (medical)
引用统计
被引频次:149[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符https://kms.wmu.edu.cn/handle/3ETUA0LF/20925
专题第一临床医学院(信息与工程学院)、附属第一医院_妇产科学_生殖医学中心
附属第一医院
通讯作者Agarwal, Ashok
作者单位
1.American Center for Reproductive Medicine,Cleveland Clinic,United States;
2.Department of Urology,Cleveland Clinic,Cleveland,United States;
3.Department of Medical Bioscience,University of the Western Cape,Cape Town,South Africa;
4.Department of Urology,Lilavati Hospital and Research Centre,Mumbai,India;
5.School of Biosciences,University of Kent,Canterbury,United Kingdom;
6.Department of Urology,University of Miami,Miami,United States;
7.Department of Urology,Loma Linda University Health,Loma Linda,United States;
8.Department of Obstetrics Gynaecology and Reproductive Medicine,Flinders University,Bedford Park,Australia;
9.Division of Urology,Department of Surgery,University of Campinas (UNICAMP),Campinas,Brazil;
10.Faculty of Health,Aarhus University,Aarhus,Denmark;
11.Department of Urology,Hamad Medical Corporation,Weill Cornell Medicine-Qatar,Doha,Qatar;
12.Centro Androgen,La Coruña,Spain;
13.School of BioSciences,University of Melbourne,Parkville,Australia;
14.Section of Investigative Medicine,Imperial College London,United Kingdom;
15.Department of Andrology,Hammersmith Hospital,London,United Kingdom;
16.Department of Surgery,Union Hospital,Shatin,Hong Kong;
17.Department of Dermatology,Venereology and Andrology,Faculty of Medicine,Sohag University,Sohag,Egypt;
18.Boston IVF,Waltham,United States;
19.Department of Urology,University of Utah,Salt Lake City,United States;
20.Cooper University Hospital,Camden,United States;
21.Departamento de Biología,Universidad Autónoma de Madrid,Madrid,Spain;
22.Department of Urology,Pusan National University School of Medicine,Busan,South Korea;
23.Medical Research Institute of Pusan National University Hospital,Busan,South Korea;
24.Department of Surgery,McGill University,Montreal,Canada;
25.Austin Fertility and Reproductive Medicine/Westlake IVF,Austin,United States;
26.Uromedica Polyclinic,Kneza Milosa,Belgrade,Serbia;
27.Department of Urology,University of Virginia,Charlottesville,United States;
28.Sapienza University of Rome,Rome,Italy;
29.Istanbul Florence Nightingale Hospital,Istanbul,Turkey;
30.Department of Dermatology,University Hospital Bonn,Bonn,Germany;
31.Division of Endocrinology,Department of Clinical and Molecular Sciences,Polytechnic University of Marche,Umberto I Hospital,Ancona,Italy;
32.IVI Foundation Edificio Biopolo,Instituto de Investigacion Sanitaria la Fe,Valencia,Spain;
33.University Hospital,School of Medicine,PERITOX Laboratory,Amiens,France;
34.Division of Urology,Southern Illinois University School of Medicine,Springfield,United States;
35.Centre for Human Reproductive Science,IMSR,College of Medical and Dental Sciences,University of Birmingham Edgbaston,United Kingdom;
36.Birmingham Women's Fertility Centre,Birmingham Women's and Children's NHS Foundation Trust,Mindelsohn Drive,Edgbaston,United Kingdom;
37.Department of Obstetrics and Gynaecology,University of Toronto,Toronto,Canada;
38.Reproductive Medicine Center,First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China;
39.Fertility Medical Group,Sao Paulo,Brazil;
40.Department of Obstetrics and Gynecology,Andrology Unit Faculties of Health Sciences,Tygerberg Hospital,Tygerberg,South Africa;
41.Department of Urology,Icahn School of Medicine at Mount Sinai,New York,United States;
42.IVF Japan Group,Horac Grand Front Osaka Clinic,Osaka,Japan;
43.Manipal Fertility,Bangalore,India;
44.Genk Institute for Fertility Technology,Genk,Belgium;
45.Hasselt University,Biomedical Research Institute,Diepenbeek,Belgium;
46.Department of Experimental and Clinical Medicine,Center of Excellence DeNothe,University of Florence,Italy;
47.Department of Experimental and Clinical Biomedical Sciences 'Mario Serio',Unit of Sexual Medicine and Andrology,Center of Excellence DeNothe,University of Florence,Florence,Italy;
48.Department of Urology,Reproduction Center,Yokohama City University Medical Center,Yokohama,Japan;
49.Department of Clinical and Experimental Medicine,University of Catania,Catania,Italy;
50.Androbest Andrology and Urology Center,Hyderabad,India;
51.Section of Urology,University of Santo Tomas Hospital,Manila,Philippines;
52.SCSA Diagnostics,Brookings,United States;
53.Fleury Group and Hospital Israelita Albert Einstein,Sao Paulo,Brazil;
54.Origen,Center for Reproductive Medicine,Rio de Janeiro,Brazil;
55.Department of Urology,University of Sao Paulo (USP),Brazil;
56.Division of Urology,Infertility Center ALFA,Sao Paulo,Brazil;
57.Male Infertility Division,Andrology Department,Brazilian Society of Urology,Rio de Janeiro,Brazil;
58.Fertility and IVF Unit,Department of Obstetrics and Gynecology,Hebrew-University Hadassah Medical Center,Jerusalem,Israel;
59.Infertility and IVF Unit,Department of Obstetrics and Gynecology,Chaim Sheba Medical Center (Tel Hashomer),Ramat Gan,Israel;
60.Tarnesby-Tarnowski Chair for Family Planning and Fertility Regulation,Sackler Faculty of Medicine,Tel-Aviv University,Tel Aviv,Israel;
61.Soroka University Medical Center,Ben-Gurion University of the Negev Beer-Sheva,Beersheba,Israel;
62.IVF Unit,Meir Medical Center,Kfar Sava,Israel;
63.Sackler Medicine School,Tel Aviv University,Tel Aviv,Israel;
64.Department of Urology,Hamad Medical Corporation,Doha,Qatar;
65.Department of Andrology and Urology,Diyos Hospital,New Delhi,India;
66.PUR Clinic,South Lake Hospital,Clermont,United States;
67.University of Central Florida,Orlando,United States;
68.Baby Center,Institute for Reproductive Medicine,United States;
69.College Institute of Clinical Research and Teaching Development,São Paulo,Brazil;
70.Lab for Molecular Reproduction and Genetics,Anatomy,All India Institute of Medical Sciences,New Delhi,India;
71.Department of Reproductive Biology,Hopitaux Universitaires Paris Seine Saint-Denis,Bondy,France;
72.Department of Reproductive Medicine and Embryology,Manipal Hospital,New Delhi,India;
73.Department of Urology,Hacettepe University Faculty of Medicine,Ankara,Turkey;
74.Department of Endocrinology/Andrology,University Hospital Ghent,Ghent,Belgium;
75.Department of Reproductive Medicine,Hannibal International Clinic,Tunis,Tunisia;
76.Department of Obstetrics,Gynecology and Reproductive Medicine,Pierre Cherest and Hartman Clinics,Paris,France;
77.Clinic of Urology,Clinical Centre of Serbia,Faculty of Medicine,University of Belgrade,Belgrade,Serbia;
78.Department of Physiology,Faculty of Medicine,Universiti Teknologi MARA,Sungai Buloh Campus,Jalan Hospital,Selangor,Malaysia;
79.Department of Embryology,Faculty of Medicine,University of Sousse,Sousse,Tunisia;
80.Department of Pediatrics,New York University School of Medicine,New York,United States;
81.Department of Obstetrics and Gynaecology,Lilavati Hospital and Research Centre,Mumbai,India;
82.Department of Experimental Medicine,Sapienza University of Rome,Rome,Italy;
83.School of Natural Medicine,University of the Western Cape,Cape Town,South Africa;
84.Department of Andrology,Shahid Sadoughi Medical University,Yazd,Iran;
85.Southend Fertility and IVF,Delhi,India;
86.Department of Urology,School of Medicine,University of Ankara,Ankara,Turkey;
87.Redox Biology Laboratory,Department of Zoology,Center of Excellence in Environment and Public Health,Ravenshaw University,Cutrack,India;
88.Marrakech Fertility Institute,Marrakech,Morocco;
89.Jindal Hospital,Meerut,India;
90.Department of Urology,Istinye University Faculty of Medicine,Liv Hospital Ulus,Istanbul,Turkey;
91.Department of Urology,Ege University School of Medicine,Izmir,Turkey;
92.Center of Urology,CODRA Hospital,Podgorica,Montenegro;
93.Fertility and IVF Unit,Soroka University Medical Center,Ben Gurion University of the Negev,Beer Sheva,Israel;
94.Harvard Medical School,Boston,United States
推荐引用方式
GB/T 7714
Agarwal, Ashok,Parekh, Neel,Selvam, Manesh Kumar Panner,et al. Male Oxidative Stress Infertility (MOSI): Proposed Terminology and Clinical Practice Guidelines for Management of Idiopathic Male Infertility[J]. WORLD JOURNAL OF MENS HEALTH,2019,37(3):296-312.
APA Agarwal, Ashok., Parekh, Neel., Selvam, Manesh Kumar Panner., Henkel, Ralf., Shah, Rupin., ... & Harlev, Avi. (2019). Male Oxidative Stress Infertility (MOSI): Proposed Terminology and Clinical Practice Guidelines for Management of Idiopathic Male Infertility. WORLD JOURNAL OF MENS HEALTH, 37(3), 296-312.
MLA Agarwal, Ashok,et al."Male Oxidative Stress Infertility (MOSI): Proposed Terminology and Clinical Practice Guidelines for Management of Idiopathic Male Infertility".WORLD JOURNAL OF MENS HEALTH 37.3(2019):296-312.

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