Role of Ketotifen on metabolic profiles, inflammation and oxidative stress in diabetic rats

doi:10.1507/endocrj.EJ16-0458

科研成果详情

题名	Role of Ketotifen on metabolic profiles, inflammation and oxidative stress in diabetic rats
作者	Chen, Zimiao1,2; Sun, Hongwei3; Wang, Jian4; Ni, Liansong2; Gu, Xuejiang2; Ge, Shengjie2; Chen, Qiong5; Mu, Liangshan 6; Cheng, Xingbo 1
发表日期	2017-04
发表期刊	ENDOCRINE JOURNAL 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Ketotifen Diabetes mellitus Mast cell Inflammation Dyslipidemia
其他关键词	REACTIVE OXYGEN METABOLITES ; MAST-CELL ; TYPE-2 ; ADIPOKINE ; MELLITUS ; PROTEIN ; RISK
摘要	We aim to explore effects of Ketotifen on metabolic profiles, inflammation and oxidative stress. Sprague Dawley (SD) male rats were randomly divided into normal control group (NC) and experimental groups, and experimental group rats were fed with high-sugar and fat diet for 6 weeks. Then, experimental group rats were divided into diabetes group (DM) and ketotifen treatment group (KT). KT group was given ketotifen via Intragastric for 8 weeks with the dosage of 0.09 mg/kg/d. Fasting plasma glucose (FPG) was measured using glucose oxidase-phenol amino phenazone method. Fasting insulin (FINS), total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL), high -density lipoprotein (HDL), interleulcin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) were tested by enzyme-linked immunosorbent assay. Malondialdehyde (MDA) and superoxide dismutase (SOD) were quantified by spectrophotometer method. Before Ketotifen administration, compared with NC group, DM and KT groups showed significantly high levels of body weight, FPG, FINS, HOMA-IR, TC, TG, LDL, IL-6, TNF-a and MDA, and lower levels of HDL and SOD (Allp<0.05). After 4 weeks of Ketotifen administration, levels of body weight, FPG, FINS, HOMA-IR, TC, TG, LDL, IL-6, TNF-a in KT group decreased significantly, and levels of HDL and SOD elevated significantly (All p<0.05). After 8 weeks of Ketotifen administration, levels of body weight, FPG, FINS, HOMA-IR, TC, TG, LDL, IL-6, TNF-a and MDA in KT group decreased more obviously, and levels of HDL and SOD elevated significantly further (All p<0.05). Ketotifen improved metabolic profiles, and ameliorated status of inflammation and oxidative stress.
资助项目	Wenzhou Science and Technology Bureau in China [Y200100063]; Natural Science Foundation of Zhejiang ProvinceNatural Science Foundation of Zhejiang Province [LQ12H07003]; Traditional Chinese Medicine Science and Technology Planning of Zhejiang Province [2012ZB104]
出版者	JAPAN ENDOCRINE SOC
出版地	KYOTO
ISSN	0918-8959
EISSN	1348-4540
卷号	64 期号:4 页码:411-416
DOI	10.1507/endocrj.EJ16-0458
页数	6
WOS类目	Endocrinology & Metabolism
WOS研究方向	Endocrinology & Metabolism
WOS记录号	WOS:000401684900006
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	28321031
SCOPUSEID	2-s2.0-85018319809
通讯作者地址	[Mu, Liangshan]Reproductive Medicine Center,The First Affiliated Hospital of Wenzhou Medical University,No.2 Fuxue Road,Wenzhou,325000,China
Scopus学科分类	Endocrinology, Diabetes and Metabolism;Endocrinology
引用统计	被引频次：2[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/2087
专题	附属第一医院_内分泌科第一临床医学院（信息与工程学院）、附属第一医院附属第二医院第二临床医学院、附属第二医院、育英儿童医院第一临床医学院（信息与工程学院）、附属第一医院_妇产科学_生殖医学中心
通讯作者	Mu, Liangshan
作者单位	1.Department of Endocrinology,The First Affiliated Hospital of Soochow University,Suzhou,215000,China; 2.Department of Endocrinology,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China; 3.Department of Surgery,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China; 4.Department of Hand Surgery,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China; 5.Department of Neurosurgery,The Second Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China; 6.Reproductive Medicine Center,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China
第一作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院
通讯作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院; 生殖医学中心
推荐引用方式 GB/T 7714	Chen, Zimiao,Sun, Hongwei,Wang, Jian,et al. Role of Ketotifen on metabolic profiles, inflammation and oxidative stress in diabetic rats[J]. ENDOCRINE JOURNAL,2017,64(4):411-416.
APA	Chen, Zimiao., Sun, Hongwei., Wang, Jian., Ni, Liansong., Gu, Xuejiang., ... & Cheng, Xingbo. (2017). Role of Ketotifen on metabolic profiles, inflammation and oxidative stress in diabetic rats. ENDOCRINE JOURNAL, 64(4), 411-416.
MLA	Chen, Zimiao,et al."Role of Ketotifen on metabolic profiles, inflammation and oxidative stress in diabetic rats".ENDOCRINE JOURNAL 64.4(2017):411-416.