The emerging roles of irisin in vascular calcification

doi:10.3389/fendo.2024.1337995

科研成果详情

题名	The emerging roles of irisin in vascular calcification
作者	Wang, Shuangshuang1; Hu, Siwang2; Pan, Yuping 3
发表日期	2024-02-09
发表期刊	Frontiers in endocrinology 影响因子和分区
语种	英语
原始文献类型	Journal Article ; Review
关键词	irisin predictor protective role risk factors vascular calcification
其他关键词	PERIVASCULAR ADIPOSE-TISSUE ; CHRONIC KIDNEY-DISEASE ; HEME OXYGENASE-1/ADIPONECTIN AXIS ; ENDOTHELIAL PROGENITOR CELLS ; SMOOTH-MUSCLE-CELLS ; SERUM IRISIN ; CIRCULATING IRISIN ; DIABETES-MELLITUS ; BODY-COMPOSITION ; CARDIOVASCULAR EVENTS
摘要	Vascular calcification is a common accompanying pathological change in many chronic diseases, which is caused by calcium deposition in the blood vessel wall and leads to abnormal blood vessel function. With the progress of medical technology, the diagnosis rate of vascular calcification has explosively increased. However, due to its mechanism's complexity, no effective drug can relieve or even reverse vascular calcification. Irisin is a myogenic cytokine regulating adipose tissue browning, energy metabolism, glucose metabolism, and other physiological processes. Previous studies have shown that irisin could serve as a predictor for vascular calcification, and protect against hypertension, diabetes, chronic kidney disease, and other risk factors for vascular calcification. In terms of mechanism, it improves vascular endothelial dysfunction and phenotypic transformation of vascular smooth muscle cells. All the above evidence suggests that irisin plays a predictive and protective role in vascular calcification. In this review, we summarize the association of irisin to the related risk factors for vascular calcification and mainly explore the role of irisin in vascular calcification.
资助项目	Zhejiang Provincial Program for Medicine and Health [2022KY446, 2023KY411, 2023KY1347]; Social Development Science and Technology Foundation of Taizhou [21ywb115, 21ywb118, 20ywb143]; Social Development Science and Technology Foundation of Wenling [2020S0180083, 2021S00156, 2021S00197, 2020S0180127]
出版者	FRONTIERS MEDIA SA
ISSN	1664-2392
卷号	15
DOI	10.3389/fendo.2024.1337995
页数	10
WOS类目	Endocrinology & Metabolism
WOS研究方向	Endocrinology & Metabolism
WOS记录号	WOS:001169369800001
收录类别	PUBMED ; SCIE
URL	查看原文
Pubmed记录号	38405155
通讯作者地址	[Pan, Yuping]Yuhuan Second Peoples Hosp, Dept Internal Med, Yuhuan, Zhejiang, Peoples R China.
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/207738
专题	其他_附属温岭医院（温岭市第一人民医院）
通讯作者	Pan, Yuping
作者单位	1.Wenzhou Med Univ, Peoples Hosp Wenling 1, Dept Cardiol, Affiliated Wenling Hosp, Wenling, Zhejiang, Peoples R China; 2.Wenzhou Med Univ, Peoples Hosp Wenling 1, Orthopaed Ctr, Affiliated Wenling Hosp, Wenling, Zhejiang, Peoples R China; 3.Yuhuan Second Peoples Hosp, Dept Internal Med, Yuhuan, Zhejiang, Peoples R China
第一作者单位	附属温岭医院（温岭市第一人民医院）
第一作者的第一单位	附属温岭医院（温岭市第一人民医院）
推荐引用方式 GB/T 7714	Wang, Shuangshuang,Hu, Siwang,Pan, Yuping. The emerging roles of irisin in vascular calcification[J]. Frontiers in endocrinology,2024,15.
APA	Wang, Shuangshuang, Hu, Siwang, & Pan, Yuping. (2024). The emerging roles of irisin in vascular calcification. Frontiers in endocrinology, 15.
MLA	Wang, Shuangshuang,et al."The emerging roles of irisin in vascular calcification".Frontiers in endocrinology 15(2024).