Tryptanthrin promotes pressure ulcers healing in mice by inhibiting macrophage-mediated inflammation via cGAS/STING pathways

doi:10.1016/j.intimp.2024.111687

科研成果详情

题名	Tryptanthrin promotes pressure ulcers healing in mice by inhibiting macrophage-mediated inflammation via cGAS/STING pathways
作者	He, Yaozhi 1; Yue, Juanqing 2; Teng, Yiwei 3; Fan, Ziwei1; Jia, Mengxian1; Teng, Honglin1; Zhuge, Linmin 4
发表日期	2024-03-30
发表期刊	International immunopharmacology 影响因子和分区
语种	英语
原始文献类型	Journal Article
关键词	Inflammation Polarization Pressures ulcers Tryptanthrin cGAS/STING
其他关键词	REPERFUSION INJURY ; PREVENTION ; ISCHEMIA ; REPAIR
摘要	Pressure ulcers (PUs) is ischemic necrosis caused by long-term local tissue pressure, directly affecting postoperative functional recovery. There is evidence that inflammation has an adverse impact on the development of PUs and contributes to unfavorable outcomes, suggesting that blocking the inflammatory response may be a promising therapeutic strategy for PUs. Tryptanthrin (Tryp), a natural product isolated from indigenous plants, has an anti-inflammatory biological function. However, the efficacy of Tryp in PUs remains unclear., Efficacy of Tryp suppressed inflammation was assessed using magnets-induced PUs model in mice. Hematoxylin-Eosin staining, masson staining and immunohistochemistry were used to evaluate the histologic changes after the formation of PUs. The expression of inflammatory cytokines was detected by qRT-PCR. And we detected the expression of protein by Western blotting., Tryp could promote wound healing, such as epidermal thickening, revascularization, and nerve regeneration. Then the treatment of Tryp was able to promote fibroblast migration and collagen deposition. Moreover, Tryp attenuated inflammation through inducing macrophage polarization to M2 phenotype by suppressing the activation of cGAS-STING pathway., Tryp could reduce the release of inflammatory cytokines, and induce RAW 264.7 polarization to M2 phenotype by targeting cGAS/STING/TBK1 pathways. In summary, Tryp may be a novel medicine for the treatment of PUs in the future.
资助项目	Medical and Health Technology Project of Hangzhou[A20220598];
出版者	ELSEVIER
ISSN	1567-5769
EISSN	1878-1705
卷号	130
DOI	10.1016/j.intimp.2024.111687
页数	10
WOS类目	Immunology ; Pharmacology & Pharmacy
WOS研究方向	Immunology ; Pharmacology & Pharmacy
WOS记录号	WOS:001200190400001
收录类别	PUBMED ; SCOPUS ; SCIE
在线发表日期	2024-02
URL	查看原文
PubMed ID	3838226
SCOPUSEID	2-s2.0-85185788468
通讯作者地址	[Zhuge, Linmin]Department of Gastrointestinal Surgery,The Second Affiliated Hospital of Wenzhou Medical University,Zhejiang,Wenzhou,China
Scopus学科分类	Immunology and Allergy;Immunology;Pharmacology
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/207686
专题	附属第一医院附属第二医院第二临床医学院、附属第二医院、育英儿童医院仁济学院
通讯作者	Zhuge, Linmin
作者单位	1.Department of Orthopedics (Spine Surgery),The First Affiliated Hospital of Wenzhou Medical University,Zhejiang,Wenzhou,China; 2.(Department of Pathology) Affiliated Hangzhou First People's Hospital,School of Medicine,Westlake University,Zhejiang,Hangzhou,China; 3.Renji College,Wenzhou Medical University,Zhejiang,Wenzhou,China; 4.Department of Gastrointestinal Surgery,The Second Affiliated Hospital of Wenzhou Medical University,Zhejiang,Wenzhou,China
第一作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院
通讯作者单位	第二临床医学院，附属第二医院、育英儿童医院; 附属第二医院
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	He, Yaozhi,Yue, Juanqing,Teng, Yiwei,et al. Tryptanthrin promotes pressure ulcers healing in mice by inhibiting macrophage-mediated inflammation via cGAS/STING pathways[J]. International immunopharmacology,2024,130.
APA	He, Yaozhi., Yue, Juanqing., Teng, Yiwei., Fan, Ziwei., Jia, Mengxian., ... & Zhuge, Linmin. (2024). Tryptanthrin promotes pressure ulcers healing in mice by inhibiting macrophage-mediated inflammation via cGAS/STING pathways. International immunopharmacology, 130.
MLA	He, Yaozhi,et al."Tryptanthrin promotes pressure ulcers healing in mice by inhibiting macrophage-mediated inflammation via cGAS/STING pathways".International immunopharmacology 130(2024).