Aetiology of severe community acquired pneumonia in adults identified by combined detection methods: a multi-centre prospective study in China

doi:10.1080/22221751.2022.2035194

科研成果详情

题名	Aetiology of severe community acquired pneumonia in adults identified by combined detection methods: a multi-centre prospective study in China
作者	Qu, Jieming 1,2; Zhang, Jing 3; Chen, Yu 4; Huang, Yi 5; Xie, Yusang 1,2; Zhou, Min 1,2; Li, Yuping6; Shi, Dongwei 7; Xu, Jinfu 8; Wang, Qiuyue 9; He, Bei 10; Shen, Ning 10; Cao, Bin 11; She, Danyang 12; Shi, Yi 13; Su, Xin 13; Zhou, Hua 14; Fan, Hong 15; Ye, Feng 16; Zhang, Qiao 17; Tian, Xinlun 18; Lai, Guoxiang 19
发表日期	2022-12-31
发表期刊	EMERGING MICROBES & INFECTIONS 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Severe community acquired pneumonia mNGS combined detection multi-centre study Chlamydia Psittaci
其他关键词	ACUTE RESPIRATORY SYNDROME ; THORACIC SOCIETY ; DIAGNOSIS ; INFECTIONS ; MORTALITY ; PSITTACOSIS ; RESPONSES ; TESTS
摘要	Severe Community Acquired Pneumonia (SCAP) challenges public health globally. Considerable improvements in molecular pathogen testing emerged in the last few years. Our prospective study combinedly used traditional culture, antigen tests, PCR and mNGS in SCAP pathogen identification with clinical outcomes. From June 2018 to December 2019, we conducted a multi-centre prospective study in 17 hospitals of SCAP patients within 48 hours of emergency room stay or hospitalization in China. All clinical data were uploaded into an online database. Blood, urine and respiratory specimens were collected for routine culture, antigen detection, PCR and mNGS as designed appropriately. Aetiology confirmation was made by the local attending physician group and scientific committee according to microbiological results, clinical features, and response to the treatment. Two hundred seventy-five patients were included for final analysis. Combined detection methods made identification rate up to 74.2% (222/299), while 14.4% (43/299) when only using routine cultures and 40.8% (122/299) when not using mNGS. Influenza virus (23.2%, 46/198), S. pneumoniae (19.6%, 39/198), Enterobacteriaceae (14.6%, 29/198), Legionella pneumophila (12.6%, 25/198), Mycoplasma pneumoniae (11.1%, 22/198) were the top five common pathogens. The in-hospital mortality of patients with pathogen identified and unidentified was 21.7% (43/198) and 25.9% (20/77), respectively. In conclusion, early combined detection increased the pathogen identification rate and possibly benefitted survival. Influenza virus, S. pneumoniae, Enterobacteriaceae was the leading cause of SCAP in China, and there was a clear seasonal distribution pattern of influenza viruses. Physicians should be aware of the emergence of uncommon pathogens, including Chlamydia Psittaci and Leptospira.
资助项目	Severe Pneumonia Cohort and Biological Sample Data Repository [SHDC2020CR5010] ; Cultivation Project of Shanghai Major Infectious Disease Research Base [20dz2210500] ; Key Laboratory of Emergency Prevention, Diagnosis and Treatment of Respiratory Infectious Diseases, Shanghai [20dz2261100] ; National Innovative Research Team of High-level Local Universities in Shanghai
出版者	TAYLOR & FRANCIS LTD
出版地	ABINGDON
ISSN	2222-1751
EISSN	2222-1751
卷号	11 期号:1 页码:556-566
DOI	10.1080/22221751.2022.2035194
页数	11
WOS类目	Immunology ; Infectious Diseases ; Microbiology
WOS研究方向	Immunology ; Infectious Diseases ; Microbiology
WOS记录号	WOS:000753672500001
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
Pubmed记录号	35081880
PMC记录号	PMC8843176
Scopus记录号	2-s2.0-85124439728
ESI高被引论文	2024-01 ; 2024-07
通讯作者地址	[Qu, Jieming]Department of Pulmonary and Critical Care Medicine,Ruijin Hospital,Institute of Respiratory Diseases,School of Medicine,Shanghai Jiao Tong University,Shanghai,China
scopus学科分类	Epidemiology;Parasitology;Microbiology;Immunology;Drug Discovery;Infectious Diseases;Virology
引用统计	被引频次：4[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/20754
专题	第一临床医学院（信息与工程学院）、附属第一医院_内科学_呼吸与危重症医学科附属第一医院
通讯作者	Qu, Jieming
作者单位	1.Department of Pulmonary and Critical Care Medicine,Ruijin Hospital,Institute of Respiratory Diseases,School of Medicine,Shanghai Jiao Tong University,Shanghai,China; 2.Institute of Respiratory Diseases,School of Medicine,Shanghai Jiao Tong University,Shanghai,China; 3.Department of Pulmonary and Critical Care Medicine,Zhongshan Hospital,Shanghai Medical College,Fudan University,Shanghai,China; 4.Department of Pulmonary and Critical Care Medicine,Shengjing Hospital of China Medical University,Shenyang,China; 5.Department of Pulmonary and Critical Care Medicine,Changhai Hospital,Shanghai,China; 6.Department of Pulmonary and Critical Care Medicine,The First Affiliated Hospital Wenzhou Medical College,Zhejiang,China; 7.Department of Emergency Medicine,Zhongshan Hospital,Shanghai Medical College,Fudan University,Shanghai,China; 8.Department of Pulmonary and Critical Care Medicine,Shanghai Pulmonary Hospital,Tongji University,Shanghai,China; 9.Department of Pulmonary and Critical Care Medicine,The First Hospital of China Medical University,Shenyang,China; 10.Department of Pulmonary and Critical Care Medicine,Peking University Third Hospital,Beijing,China; 11.Department of Pulmonary and Critical Care Medicine,Friendship Hospital,Beijing,China; 12.Department of Pulmonary and Critical Care Medicine,The General Hospital of the People's Liberation Army,Beijing,China; 13.Department of Pulmonary and Critical Care Medicine,Jinling Hospital,Nanjing,China; 14.Department of Pulmonary and Critical Care Medicine,The First Affiliated Hospital Zhejiang University,Hangzhou,China; 15.Department of Pulmonary and Critical Care Medicine,West China Hospital,Sichuan University,Sichuan,China; 16.Department of Pulmonary and Critical Care Medicine,The First Affiliate Hospital of Guangzhou Medical University,Guangzhou,China; 17.Department of Pulmonary and Critical Care Medicine,Xinqiao Hospital of Army Medical University,Chongqing,China; 18.Department of Pulmonary and Critical Care Medicine,Peking Union Medical College Hospital,Beijing,China; 19.Department of Pulmonary and Critical Care Medicine,Fuzhou General Hospital,Fuzhou,China
推荐引用方式 GB/T 7714	Qu, Jieming,Zhang, Jing,Chen, Yu,et al. Aetiology of severe community acquired pneumonia in adults identified by combined detection methods: a multi-centre prospective study in China[J]. EMERGING MICROBES & INFECTIONS,2022,11(1):556-566.
APA	Qu, Jieming., Zhang, Jing., Chen, Yu., Huang, Yi., Xie, Yusang., ... & Lai, Guoxiang. (2022). Aetiology of severe community acquired pneumonia in adults identified by combined detection methods: a multi-centre prospective study in China. EMERGING MICROBES & INFECTIONS, 11(1), 556-566.
MLA	Qu, Jieming,et al."Aetiology of severe community acquired pneumonia in adults identified by combined detection methods: a multi-centre prospective study in China".EMERGING MICROBES & INFECTIONS 11.1(2022):556-566.