题名 | Aetiology of severe community acquired pneumonia in adults identified by combined detection methods: a multi-centre prospective study in China |
作者 | |
发表期刊 | EMERGING MICROBES & INFECTIONS 影响因子和分区 |
语种 | 英语 |
原始文献类型 | Article |
关键词 | Severe community acquired pneumonia mNGS combined detection multi-centre study Chlamydia Psittaci |
其他关键词 | ACUTE RESPIRATORY SYNDROME ; THORACIC SOCIETY ; DIAGNOSIS ; INFECTIONS ; MORTALITY ; PSITTACOSIS ; RESPONSES ; TESTS |
摘要 | Severe Community Acquired Pneumonia (SCAP) challenges public health globally. Considerable improvements in molecular pathogen testing emerged in the last few years. Our prospective study combinedly used traditional culture, antigen tests, PCR and mNGS in SCAP pathogen identification with clinical outcomes. From June 2018 to December 2019, we conducted a multi-centre prospective study in 17 hospitals of SCAP patients within 48 hours of emergency room stay or hospitalization in China. All clinical data were uploaded into an online database. Blood, urine and respiratory specimens were collected for routine culture, antigen detection, PCR and mNGS as designed appropriately. Aetiology confirmation was made by the local attending physician group and scientific committee according to microbiological results, clinical features, and response to the treatment. Two hundred seventy-five patients were included for final analysis. Combined detection methods made identification rate up to 74.2% (222/299), while 14.4% (43/299) when only using routine cultures and 40.8% (122/299) when not using mNGS. Influenza virus (23.2%, 46/198), S. pneumoniae (19.6%, 39/198), Enterobacteriaceae (14.6%, 29/198), Legionella pneumophila (12.6%, 25/198), Mycoplasma pneumoniae (11.1%, 22/198) were the top five common pathogens. The in-hospital mortality of patients with pathogen identified and unidentified was 21.7% (43/198) and 25.9% (20/77), respectively. In conclusion, early combined detection increased the pathogen identification rate and possibly benefitted survival. Influenza virus, S. pneumoniae, Enterobacteriaceae was the leading cause of SCAP in China, and there was a clear seasonal distribution pattern of influenza viruses. Physicians should be aware of the emergence of uncommon pathogens, including Chlamydia Psittaci and Leptospira. |
资助项目 | Severe Pneumonia Cohort and Biological Sample Data Repository [SHDC2020CR5010] ; Cultivation Project of Shanghai Major Infectious Disease Research Base [20dz2210500] ; Key Laboratory of Emergency Prevention, Diagnosis and Treatment of Respiratory Infectious Diseases, Shanghai [20dz2261100] ; National Innovative Research Team of High-level Local Universities in Shanghai |
出版者 | TAYLOR & FRANCIS LTD |
出版地 | ABINGDON |
ISSN | 2222-1751 |
EISSN | 2222-1751 |
卷号 | 11期号:1页码:556-566 |
DOI | 10.1080/22221751.2022.2035194 |
页数 | 11 |
WOS类目 | Immunology ; Infectious Diseases ; Microbiology |
WOS研究方向 | Immunology ; Infectious Diseases ; Microbiology |
WOS记录号 | WOS:000753672500001 |
收录类别 | SCIE ; PUBMED ; SCOPUS |
发表日期 | 2022-12-31 |
URL | 查看原文 |
Pubmed记录号 | 35081880 |
PMC记录号 | PMC8843176 |
Scopus记录号 | 2-s2.0-85124439728 |
ESI高被引论文 | 2024-01 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | https://kms.wmu.edu.cn/handle/3ETUA0LF/20754 |
专题 | 第一临床医学院(信息与工程学院)、附属第一医院_内科学_呼吸与危重症医学科 |
通讯作者 | Qu, Jieming |
作者单位 | 1.Shanghai Jiao Tong Univ, Ruijin Hosp, Sch Med, Inst Resp Dis,Dept Pulm & Crit Care Med, Shanghai, Peoples R China; 2.Shanghai Jiao Tong Univ, Sch Med, Inst Resp Dis, Shanghai, Peoples R China; 3.Fudan Univ, Zhongshan Hosp, Shanghai Med Coll, Dept Pulm & Crit Care Med, Shanghai, Peoples R China; 4.China Med Univ, Shengjing Hosp, Dept Pulm & Crit Care Med, Shenyang, Peoples R China; 5.Changhai Hosp, Dept Pulm & Crit Care Med, Shanghai, Peoples R China; 6.Wenzhou Med Coll, Affiliated Hosp 1, Dept Pulm & Crit Care Med, Wenzhou, Zhejiang, Peoples R China; 7.Fudan Univ, Zhongshan Hosp, Shanghai Med Coll, Dept Emergency Med, Shanghai, Peoples R China; 8.Tongji Univ, Shanghai Pulm Hosp, Dept Pulm & Crit Care Med, Shanghai, Peoples R China; 9.China Med Univ, Hosp 1, Dept Pulm & Crit Care Med, Shenyang, Peoples R China; 10.Peking Univ Third Hosp, Dept Pulm & Crit Care Med, Beijing, Peoples R China; 11.China Japan Friendship Hosp, Dept Pulm & Crit Care Med, Beijing, Peoples R China; 12.Peoples Liberat Army, Gen Hosp, Dept Pulm & Crit Care Med, Beijing, Peoples R China; 13.Jinling Hosp, Dept Pulm & Crit Care Med, Nanjing, Peoples R China; 14.Zhejiang Univ, Affiliated Hosp 1, Dept Pulm & Crit Care Med, Hangzhou, Peoples R China; 15.Sichuan Univ, West China Hosp, Dept Pulm & Crit Care Med, Chengdu, Sichuan, Peoples R China; 16.Guangzhou Med Univ, Affiliate Hosp 1, Dept Pulm & Crit Care Med, Guangzhou, Peoples R China; 17.Army Med Univ, Xinqiao Hosp, Dept Pulm & Crit Care Med, Chongqing, Peoples R China; 18.Peking Union Med Coll Hosp, Dept Pulm & Crit Care Med, Beijing, Peoples R China; 19.Fuzhou Gen Hosp, Dept Pulm & Crit Care Med, Fuzhou, Peoples R China |
推荐引用方式 GB/T 7714 | Qu, Jieming,Zhang, Jing,Chen, Yu,et al. Aetiology of severe community acquired pneumonia in adults identified by combined detection methods: a multi-centre prospective study in China[J]. EMERGING MICROBES & INFECTIONS,2022,11(1):556-566. |
APA | Qu, Jieming., Zhang, Jing., Chen, Yu., Huang, Yi., Xie, Yusang., ... & Lai, Guoxiang. (2022). Aetiology of severe community acquired pneumonia in adults identified by combined detection methods: a multi-centre prospective study in China. EMERGING MICROBES & INFECTIONS, 11(1), 556-566. |
MLA | Qu, Jieming,et al."Aetiology of severe community acquired pneumonia in adults identified by combined detection methods: a multi-centre prospective study in China".EMERGING MICROBES & INFECTIONS 11.1(2022):556-566. |
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