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TitleAetiology of severe community acquired pneumonia in adults identified by combined detection methods: a multi-centre prospective study in China
Creator
Date Issued2022-12-31
Source PublicationEMERGING MICROBES & INFECTIONS   Impact Factor & Quartile
language英语
Original Document TypeArticle
KeywordSevere community acquired pneumonia mNGS combined detection multi-centre study Chlamydia Psittaci
WOS KeywordACUTE RESPIRATORY SYNDROME ; THORACIC SOCIETY ; DIAGNOSIS ; INFECTIONS ; MORTALITY ; PSITTACOSIS ; RESPONSES ; TESTS
Abstract

Severe Community Acquired Pneumonia (SCAP) challenges public health globally. Considerable improvements in molecular pathogen testing emerged in the last few years. Our prospective study combinedly used traditional culture, antigen tests, PCR and mNGS in SCAP pathogen identification with clinical outcomes. From June 2018 to December 2019, we conducted a multi-centre prospective study in 17 hospitals of SCAP patients within 48 hours of emergency room stay or hospitalization in China. All clinical data were uploaded into an online database. Blood, urine and respiratory specimens were collected for routine culture, antigen detection, PCR and mNGS as designed appropriately. Aetiology confirmation was made by the local attending physician group and scientific committee according to microbiological results, clinical features, and response to the treatment. Two hundred seventy-five patients were included for final analysis. Combined detection methods made identification rate up to 74.2% (222/299), while 14.4% (43/299) when only using routine cultures and 40.8% (122/299) when not using mNGS. Influenza virus (23.2%, 46/198), S. pneumoniae (19.6%, 39/198), Enterobacteriaceae (14.6%, 29/198), Legionella pneumophila (12.6%, 25/198), Mycoplasma pneumoniae (11.1%, 22/198) were the top five common pathogens. The in-hospital mortality of patients with pathogen identified and unidentified was 21.7% (43/198) and 25.9% (20/77), respectively. In conclusion, early combined detection increased the pathogen identification rate and possibly benefitted survival. Influenza virus, S. pneumoniae, Enterobacteriaceae was the leading cause of SCAP in China, and there was a clear seasonal distribution pattern of influenza viruses. Physicians should be aware of the emergence of uncommon pathogens, including Chlamydia Psittaci and Leptospira.

Funding ProjectSevere Pneumonia Cohort and Biological Sample Data Repository [SHDC2020CR5010] ; Cultivation Project of Shanghai Major Infectious Disease Research Base [20dz2210500] ; Key Laboratory of Emergency Prevention, Diagnosis and Treatment of Respiratory Infectious Diseases, Shanghai [20dz2261100] ; National Innovative Research Team of High-level Local Universities in Shanghai
PublisherTAYLOR & FRANCIS LTD
Publication PlaceABINGDON
ISSN2222-1751
EISSN2222-1751
Volume11Issue:1Pages:556-566
DOI10.1080/22221751.2022.2035194
Page Number11
WOS SubjectImmunology ; Infectious Diseases ; Microbiology
WOS Research AreaImmunology ; Infectious Diseases ; Microbiology
WOS IDWOS:000753672500001
Indexed BySCIE ; PUBMED ; SCOPUS
URL查看原文
PubmedId35081880
PMCIDPMC8843176
scopusid2-s2.0-85124439728
ESI Hicited Paper2024-01
Corresponding author address[Qu, Jieming]Department of Pulmonary and Critical Care Medicine,Ruijin Hospital,Institute of Respiratory Diseases,School of Medicine,Shanghai Jiao Tong University,Shanghai,China
scopus subject classificationEpidemiology;Parasitology;Microbiology;Immunology;Drug Discovery;Infectious Diseases;Virology
Citation statistics
Cited Times:4[WOS]   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
Identifierhttps://kms.wmu.edu.cn/handle/3ETUA0LF/20754
Collection
Wenzhou Medical University First Affiliated Hospital
Corresponding AuthorQu, Jieming
Affiliation
1.Department of Pulmonary and Critical Care Medicine,Ruijin Hospital,Institute of Respiratory Diseases,School of Medicine,Shanghai Jiao Tong University,Shanghai,China;
2.Institute of Respiratory Diseases,School of Medicine,Shanghai Jiao Tong University,Shanghai,China;
3.Department of Pulmonary and Critical Care Medicine,Zhongshan Hospital,Shanghai Medical College,Fudan University,Shanghai,China;
4.Department of Pulmonary and Critical Care Medicine,Shengjing Hospital of China Medical University,Shenyang,China;
5.Department of Pulmonary and Critical Care Medicine,Changhai Hospital,Shanghai,China;
6.Department of Pulmonary and Critical Care Medicine,The First Affiliated Hospital Wenzhou Medical College,Zhejiang,China;
7.Department of Emergency Medicine,Zhongshan Hospital,Shanghai Medical College,Fudan University,Shanghai,China;
8.Department of Pulmonary and Critical Care Medicine,Shanghai Pulmonary Hospital,Tongji University,Shanghai,China;
9.Department of Pulmonary and Critical Care Medicine,The First Hospital of China Medical University,Shenyang,China;
10.Department of Pulmonary and Critical Care Medicine,Peking University Third Hospital,Beijing,China;
11.Department of Pulmonary and Critical Care Medicine,Friendship Hospital,Beijing,China;
12.Department of Pulmonary and Critical Care Medicine,The General Hospital of the People's Liberation Army,Beijing,China;
13.Department of Pulmonary and Critical Care Medicine,Jinling Hospital,Nanjing,China;
14.Department of Pulmonary and Critical Care Medicine,The First Affiliated Hospital Zhejiang University,Hangzhou,China;
15.Department of Pulmonary and Critical Care Medicine,West China Hospital,Sichuan University,Sichuan,China;
16.Department of Pulmonary and Critical Care Medicine,The First Affiliate Hospital of Guangzhou Medical University,Guangzhou,China;
17.Department of Pulmonary and Critical Care Medicine,Xinqiao Hospital of Army Medical University,Chongqing,China;
18.Department of Pulmonary and Critical Care Medicine,Peking Union Medical College Hospital,Beijing,China;
19.Department of Pulmonary and Critical Care Medicine,Fuzhou General Hospital,Fuzhou,China
Recommended Citation
GB/T 7714
Qu, Jieming,Zhang, Jing,Chen, Yu,et al. Aetiology of severe community acquired pneumonia in adults identified by combined detection methods: a multi-centre prospective study in China[J]. EMERGING MICROBES & INFECTIONS,2022,11(1):556-566.
APA Qu, Jieming., Zhang, Jing., Chen, Yu., Huang, Yi., Xie, Yusang., ... & Lai, Guoxiang. (2022). Aetiology of severe community acquired pneumonia in adults identified by combined detection methods: a multi-centre prospective study in China. EMERGING MICROBES & INFECTIONS, 11(1), 556-566.
MLA Qu, Jieming,et al."Aetiology of severe community acquired pneumonia in adults identified by combined detection methods: a multi-centre prospective study in China".EMERGING MICROBES & INFECTIONS 11.1(2022):556-566.

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