In situ generation of copper(Ⅱ)/diethyldithiocarbamate complex through tannic acid/copper(Ⅱ) network coated hollow mesoporous silica for enhanced cancer chemodynamic therapy

doi:10.1016/j.jcis.2024.01.121

科研成果详情

题名	In situ generation of copper(Ⅱ)/diethyldithiocarbamate complex through tannic acid/copper(Ⅱ) network coated hollow mesoporous silica for enhanced cancer chemodynamic therapy
作者	Yanfei Zhu 1; Nan Wang 1; Junhong Ling 1; Lianlian Yang 1; A M Omer 2; Xiao-Kun Ouyang 3; Guocai Yang 4
发表日期	2024-04-15
发表期刊	Journal of colloid and interface science 影响因子和分区
语种	英语
原始文献类型	Journal Article
关键词	Chemodynamic therapy Copper(Ⅱ)/diethyldithiocarbamate complex Hollow mesoporous silica Tannic acid/copper(Ⅱ) network pH-responsive release
摘要	The Cu2+ complex formed by the coordination of disulfiram (DSF) metabolite diethyldithiocarbamate (DTC), Cu(DTC)2, can effectively inhibit tumor growth. However, insufficient Cu2+ levels in the tumor microenvironment can impact tumor-suppressive effects of DTC. In this study, we proposed a Cu2+ and DSF tumor microenvironment-targeted delivery system. This system utilizes hollow mesoporous silica (HMSN) as a carrier, after loading with DSF, encases it using a complex of tannic acid (TA) and Cu2+ on the outer layer. In the slightly acidic tumor microenvironment, TA/Cu undergoes hydrolysis, releasing Cu2+ and DSF, which further form Cu(DTC)2 to inhibit tumor growth. Additionally, Cu2+ can engage in a Fenton-like reaction with H2O2 in the tumor microenvironment to form OH, therefore, chemodynamic therapy (CDT) and Cu(DTC)2 are used in combination for tumor therapy. In vivo tumor treatment results demonstrated that AHD@TA/Cu could accumulate at the tumor site, achieving a tumor inhibition rate of up to 77.6 %. This study offers a novel approach, circumventing the use of traditional chemotherapy drugs, and provides valuable insights into the development of in situ tumor drug therapies
出版者	Academic Press Inc.
ISSN	0021-9797
EISSN	1095-7103
卷号	660 页码:637-646
DOI	10.1016/j.jcis.2024.01.121
收录类别	PUBMED ; SCOPUS ; EI
EI入藏号	20240515477396
EI主题词	Copper compounds
EI分类号	461.2 Biological Materials and Tissue Engineering ; 461.6 Medicine and Pharmacology ; 722 Computer Systems and Equipment ; 802.2 Chemical Reactions ; 804.1 Organic Compounds
URL	查看原文
Pubmed记录号	38266345
Scopus记录号	2-s2.0-85183581880
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/207492
专题	其他_附属舟山医院（舟山医院）
作者单位	1.School of Food and Pharmacy, Zhejiang Ocean University, Zhoushan 316022, PR China.; 2.Polymer Materials Research Department, Advanced Technology and New Materials Research Institute (ATNMRI), City of Scientific Research and Technological Applications (SRTA-City), New Borg El-Arab City, P. O. Box: 21934, Alexandria, Egypt.; 3.School of Food and Pharmacy, Zhejiang Ocean University, Zhoushan 316022, PR China. Electronic address: xkouyang@zjou.edu.cn.; 4.Department of Cardiothoracic Surgery, Zhoushan Hospital, Wenzhou Medical University, Zhoushan 316000, PR China. Electronic address: hydygc@163.com.
推荐引用方式 GB/T 7714	Yanfei Zhu,Nan Wang,Junhong Ling,et al. In situ generation of copper(Ⅱ)/diethyldithiocarbamate complex through tannic acid/copper(Ⅱ) network coated hollow mesoporous silica for enhanced cancer chemodynamic therapy[J]. Journal of colloid and interface science,2024,660:637-646.
APA	Yanfei Zhu., Nan Wang., Junhong Ling., Lianlian Yang., A M Omer., ... & Guocai Yang. (2024). In situ generation of copper(Ⅱ)/diethyldithiocarbamate complex through tannic acid/copper(Ⅱ) network coated hollow mesoporous silica for enhanced cancer chemodynamic therapy. Journal of colloid and interface science, 660, 637-646.
MLA	Yanfei Zhu,et al."In situ generation of copper(Ⅱ)/diethyldithiocarbamate complex through tannic acid/copper(Ⅱ) network coated hollow mesoporous silica for enhanced cancer chemodynamic therapy".Journal of colloid and interface science 660(2024):637-646.