Prognostic Implications of RAB35 and its Relationship With Immune Microenvironment in Pan-cancer

科研成果详情

题名	Prognostic Implications of RAB35 and its Relationship With Immune Microenvironment in Pan-cancer
作者	Pan, Dongdong; Chen, Xueting; Zong, Yujie; Lei, Deru
发表日期	2023
发表期刊	ALTERNATIVE THERAPIES IN HEALTH AND MEDICINE 影响因子和分区
语种	英语
原始文献类型	Article
其他关键词	GTPASES ; ACTIVATION
摘要	Context . Ras-associated binding 35 (RAB35) is an oncogenic, guanosine triphosphate (GTP)ase that plays a role in cancer invasion, metastasis, and immune evasion. However, systematic and comprehensive research to identify the importance of RAB35 in various cancer types is still absent. Objective . The study intended to explore the potential value of RAB35 as a molecular biomarker. Design . The research team performed a genetic evaluation of RAB35. Setting . The study took place at the Second Affiliated Hospital of Wenzhou Medical University in Wenzhou, China. Outcome Measures . The research team assessed the expression of RAB35 in various tumor tissues and performed correlation analyses between RAB35 expression and prognosis, molecular subtypes, immunological subtypes, immune-associated cell infiltration, the tumor immune microenvironment, and drug sensitivity in pan-cancer. Results . RAB35 exhibited significant differential expression for 21 cancer types. It demonstrated high sensitivity and specificity in diagnosing eight cancer types, showed distinct expression patterns in various molecular subtypes for six cancer types, and found different immune subtypes for eight cancer types. The abnormal expression of RAB35 was significantly related to overall survival (OS) for nine cancer types, progress free interval (PFI) for five cancer types, and disease-specific survival (DSS) for five cancer types. Its abnormal expression was closely associated with the immune microenvironment and multiple immune cells. Furthermore, it was related to the drug sensitivity for various drugs and might be associated with chemotherapy resistance. Conclusions . RAB35 showed significant differential expression in various cancers and was significantly related to the prognosis of cancer patients, the immune microenvironment, multiple immune cells, drug sensitivity to various drugs, and chemotherapy resistance. It may serve as a potential biomarker and therapeutic target for cancer treatment.
出版者	InnoVision Professional Media
ISSN	1078-6791
卷号	29 期号:8 页码:452-460
页数	9
WOS类目	Integrative & Complementary Medicine
WOS研究方向	Integrative & Complementary Medicine
WOS记录号	WOS:001137669200075
收录类别	SCIE
PubMed ID	37652416
通讯作者地址	[Lei, Deru]Wenzhou Med Univ, Affiliated Hosp 2, Dept Lab Med, Wenzhou, Peoples R China.
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/207366
专题	附属第二医院_检验科
通讯作者	Lei, Deru
作者单位	Wenzhou Med Univ, Affiliated Hosp 2, Dept Lab Med, Wenzhou, Peoples R China
第一作者单位	附属第二医院_检验科
通讯作者单位	附属第二医院_检验科
第一作者的第一单位	附属第二医院_检验科
推荐引用方式 GB/T 7714	Pan, Dongdong,Chen, Xueting,Zong, Yujie,et al. Prognostic Implications of RAB35 and its Relationship With Immune Microenvironment in Pan-cancer[J]. ALTERNATIVE THERAPIES IN HEALTH AND MEDICINE,2023,29(8):452-460.
APA	Pan, Dongdong, Chen, Xueting, Zong, Yujie, & Lei, Deru. (2023). Prognostic Implications of RAB35 and its Relationship With Immune Microenvironment in Pan-cancer. ALTERNATIVE THERAPIES IN HEALTH AND MEDICINE, 29(8), 452-460.
MLA	Pan, Dongdong,et al."Prognostic Implications of RAB35 and its Relationship With Immune Microenvironment in Pan-cancer".ALTERNATIVE THERAPIES IN HEALTH AND MEDICINE 29.8(2023):452-460.