题名 | The Comprehensive Analysis of Efficacy and Safety of CalliSpheres (R) Drug-Eluting Beads Transarterial Chemoembolization in 367 Liver Cancer Patients: A Multiple-Center, Cohort Study |
作者 | Peng, Zhiyi1; Cao, Guohong2; Hou, Qinming3; Li, Ling4; Ying, Shihong1; Sun, Junhui5; Zhou, Guanhui5; Zhou, Jian6; Zhang, Xin1; Ji, Wenbin7; Yu, Zhihai8; Li, Tiefeng9; Zhu, Dedong; Hu, Wenhao10
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发表日期 | 2020 |
发表期刊 | ONCOLOGY RESEARCH 影响因子和分区 |
语种 | 英语 |
原始文献类型 | Article |
关键词 | Drug-eluting beads transarterial chemoembolization (DEB-TACE) Liver cancer Efficacy Safety Prognosis |
其他关键词 | UNRESECTABLE HEPATOCELLULAR-CARCINOMA ; CONVENTIONAL CHEMOEMBOLIZATION ; MANAGEMENT ; DIAGNOSIS ; TRIAL ; CHOLANGIOCARCINOMA ; RECOMMENDATIONS ; METASTASIS ; GUIDELINES ; EXPERIENCE |
摘要 | This study aimed to investigate the efficacy, safety, and prognostic factors of drug-eluting beads transarterial chemoembolization (DEB-TACE) in treating Chinese patients with liver cancer. A total of 367 liver cancer patients from 24 medical centers were consecutively enrolled in this multiple-center, prospective cohort study, including 275 hepatocellular carcinoma (HCC) cases, 37 intrahepatic cholangiocarcinoma (ICC) cases, and 55 secondary liver cancer cases. All the patients received CalliSpheres (R) DEB-TACE treatment. Treatment response, overall survival (OS), change of liver function, and adverse events (AEs) were assessed. DEB-TACE treatment achieved 19.9% complete response (CR) and 79.6% objective response rate (ORR), with mean OS of 384 days [95% confidence interval (CI): 375-393 days]. CR and ORR were both higher in HCC patients compared with primary ICC patients and secondary liver cancer patients, while no difference was discovered in OS. Portal vein invasion was an independent risk factor for CR, while portal vein invasion, previous conventional TACE (cTACE) treatment, and abnormal blood creatinine (BCr) were independent risk factors for ORR. In addition, largest nodule size 5.0 cm, abnormal albumin (ALB), and abnormal total bilirubin (TBIL) independently correlated with unfavorable OS. Most liver function indexes were recovered to baseline levels at 1-3 months after DEB-TACE. Common AEs were pain, fever, vomiting, and nausea most of them were at mild grade. CalliSpheres (R) DEB-TACE is efficient and well tolerated in Chinese liver cancer patients. Portal vein invasion, previous cTACE treatment, largest nodule size, abnormal BCr, ALB, and TBIL correlate with worse prognosis independently. |
资助项目 | National Nature Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81371658]; Zhejiang Provincial Natural Science Foundation of ChinaNatural Science Foundation of Zhejiang Province [LZ18H180001] |
出版者 | COGNIZANT COMMUNICATION CORP |
出版地 | PUTNAM VALLEY |
ISSN | 0965-0407 |
EISSN | 1555-3906 |
卷号 | 28期号:3页码:249-271 |
DOI | 10.3727/096504019X15766663541105 |
页数 | 23 |
WOS类目 | Oncology |
WOS研究方向 | Oncology |
WOS记录号 | WOS:000536940100004 |
收录类别 | SCIE ; SCOPUS |
URL | 查看原文 |
PubMed ID | 31856933 |
SCOPUSEID | 2-s2.0-85085537487 |
通讯作者地址 | [Shao, Guoliang]Department of Intervention,Zhejiang Cancer Hospital,1 Banshan East Road,Hangzhou,310022,China |
Scopus学科分类 | Oncology;Cancer Research |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | https://kms.wmu.edu.cn/handle/3ETUA0LF/20723 |
专题 | 附属第一医院 其他_附属第三医院(瑞安市人民医院) 其他_附属第五医院(丽水市中心医院) |
通讯作者 | Shao, Guoliang |
作者单位 | 1.Department of Radiology,First Affiliated Hospital,College of Medicine,Zhejiang University,Hangzhou,China; 2.Department of Radiology,Shulan (Hangzhou) Hospital,Zhejiang University International Hospital,Hangzhou,China; 3.Department of Radiology,Xixi Hospital of Hangzhou,Hangzhou 6th People’s Hospital,Hangzhou,China; 4.Department of Liver Oncology,Ningbo No. 2 Hospital,Ningbo,China; 5.Hepatobiliary and Pancreatic Interventional Treatment Center,Division of Hepatobiliary and Pancreatic Surgery,First Affiliated Hospital,College of Medicine,Zhejiang University,Hangzhou,China; 6.Department of Radiology,Hangzhou Cancer Hospital,Hangzhou,China; 7.Department of Radiology,Taizhou Hospital of Zhejiang Province,Linhai,China; 8.Department of Vascular and Interventional Radiology,Affiliated Hospital of Medical College,Ningbo University,Ningbo,China; 9.Department of Radiology,Beilun District People’s Hospital of Ningbo,Ningbo,China; 10.Department of Intervention,First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China; 11.Department of Radiology,Lishui Central Hospital,Lishui Hospital of Zhejiang University,Fifth Affiliated Hospital of Wenzhou Medical University,Lishui,China; 12.Department of Intervention,Dongyang People’s Hospital,Dongyang,China; 13.Department of Intervention,Third Affiliated Hospital of Wenzhou Medical University,Ruian,China; 14.Department of Intervention,Jinhua Central Hospital,Jinhua,China; 15.Department of Hepatobiliary Surgery,Quzhou People’s Hospital,Quzhou,China; 16.Department of Intervention,Jiaxing First Hospital,Jiaxing,China; 17.Department of Intervention,Jiaxing Second Hospital,Jiaxing,China; 18.Interventional Center,Xinchang People’s Hospital,Shaoxing,China; 19.Department of Radiology,First Affiliated Hospital of Zhejiang Chinese Medical University,Hangzhou,China; 20.Division of Digestive Endoscopy,Yueqing City People’s Hospital,Yueqing,China; 21.Department of Radiology,Sir Run Run Shaw Hospital,Zhejiang University College of Medicine,Hangzhou,China; 22.Department of Intervention,Zhejiang Provincial People’s Hospital,Hangzhou,China; 23.Department of Hepatobiliary Surgery,Ningbo Medical Center,Lihuili Eastern Hospital,Ningbo,China; 24.Department of Intervention,Zhejiang Cancer Hospital,Hangzhou,China |
推荐引用方式 GB/T 7714 | Peng, Zhiyi,Cao, Guohong,Hou, Qinming,et al. The Comprehensive Analysis of Efficacy and Safety of CalliSpheres (R) Drug-Eluting Beads Transarterial Chemoembolization in 367 Liver Cancer Patients: A Multiple-Center, Cohort Study[J]. ONCOLOGY RESEARCH,2020,28(3):249-271. |
APA | Peng, Zhiyi., Cao, Guohong., Hou, Qinming., Li, Ling., Ying, Shihong., ... & Shao, Guoliang. (2020). The Comprehensive Analysis of Efficacy and Safety of CalliSpheres (R) Drug-Eluting Beads Transarterial Chemoembolization in 367 Liver Cancer Patients: A Multiple-Center, Cohort Study. ONCOLOGY RESEARCH, 28(3), 249-271. |
MLA | Peng, Zhiyi,et al."The Comprehensive Analysis of Efficacy and Safety of CalliSpheres (R) Drug-Eluting Beads Transarterial Chemoembolization in 367 Liver Cancer Patients: A Multiple-Center, Cohort Study".ONCOLOGY RESEARCH 28.3(2020):249-271. |
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