科研成果详情

题名The Comprehensive Analysis of Efficacy and Safety of CalliSpheres (R) Drug-Eluting Beads Transarterial Chemoembolization in 367 Liver Cancer Patients: A Multiple-Center, Cohort Study
作者
发表日期2020
发表期刊ONCOLOGY RESEARCH   影响因子和分区
语种英语
原始文献类型Article
关键词Drug-eluting beads transarterial chemoembolization (DEB-TACE) Liver cancer Efficacy Safety Prognosis
其他关键词UNRESECTABLE HEPATOCELLULAR-CARCINOMA ; CONVENTIONAL CHEMOEMBOLIZATION ; MANAGEMENT ; DIAGNOSIS ; TRIAL ; CHOLANGIOCARCINOMA ; RECOMMENDATIONS ; METASTASIS ; GUIDELINES ; EXPERIENCE
摘要This study aimed to investigate the efficacy, safety, and prognostic factors of drug-eluting beads transarterial chemoembolization (DEB-TACE) in treating Chinese patients with liver cancer. A total of 367 liver cancer patients from 24 medical centers were consecutively enrolled in this multiple-center, prospective cohort study, including 275 hepatocellular carcinoma (HCC) cases, 37 intrahepatic cholangiocarcinoma (ICC) cases, and 55 secondary liver cancer cases. All the patients received CalliSpheres (R) DEB-TACE treatment. Treatment response, overall survival (OS), change of liver function, and adverse events (AEs) were assessed. DEB-TACE treatment achieved 19.9% complete response (CR) and 79.6% objective response rate (ORR), with mean OS of 384 days [95% confidence interval (CI): 375-393 days]. CR and ORR were both higher in HCC patients compared with primary ICC patients and secondary liver cancer patients, while no difference was discovered in OS. Portal vein invasion was an independent risk factor for CR, while portal vein invasion, previous conventional TACE (cTACE) treatment, and abnormal blood creatinine (BCr) were independent risk factors for ORR. In addition, largest nodule size 5.0 cm, abnormal albumin (ALB), and abnormal total bilirubin (TBIL) independently correlated with unfavorable OS. Most liver function indexes were recovered to baseline levels at 1-3 months after DEB-TACE. Common AEs were pain, fever, vomiting, and nausea most of them were at mild grade. CalliSpheres (R) DEB-TACE is efficient and well tolerated in Chinese liver cancer patients. Portal vein invasion, previous cTACE treatment, largest nodule size, abnormal BCr, ALB, and TBIL correlate with worse prognosis independently.
资助项目National Nature Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81371658]; Zhejiang Provincial Natural Science Foundation of ChinaNatural Science Foundation of Zhejiang Province [LZ18H180001]
出版者COGNIZANT COMMUNICATION CORP
出版地PUTNAM VALLEY
ISSN0965-0407
EISSN1555-3906
卷号28期号:3页码:249-271
DOI10.3727/096504019X15766663541105
页数23
WOS类目Oncology
WOS研究方向Oncology
WOS记录号WOS:000536940100004
收录类别SCIE ; SCOPUS
URL查看原文
PubMed ID31856933
SCOPUSEID2-s2.0-85085537487
通讯作者地址[Shao, Guoliang]Department of Intervention,Zhejiang Cancer Hospital,1 Banshan East Road,Hangzhou,310022,China
Scopus学科分类Oncology;Cancer Research
引用统计
被引频次:13[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符https://kms.wmu.edu.cn/handle/3ETUA0LF/20723
专题附属第一医院
其他_附属第三医院(瑞安市人民医院)
其他_附属第五医院(丽水市中心医院)
通讯作者Shao, Guoliang
作者单位
1.Department of Radiology,First Affiliated Hospital,College of Medicine,Zhejiang University,Hangzhou,China;
2.Department of Radiology,Shulan (Hangzhou) Hospital,Zhejiang University International Hospital,Hangzhou,China;
3.Department of Radiology,Xixi Hospital of Hangzhou,Hangzhou 6th People’s Hospital,Hangzhou,China;
4.Department of Liver Oncology,Ningbo No. 2 Hospital,Ningbo,China;
5.Hepatobiliary and Pancreatic Interventional Treatment Center,Division of Hepatobiliary and Pancreatic Surgery,First Affiliated Hospital,College of Medicine,Zhejiang University,Hangzhou,China;
6.Department of Radiology,Hangzhou Cancer Hospital,Hangzhou,China;
7.Department of Radiology,Taizhou Hospital of Zhejiang Province,Linhai,China;
8.Department of Vascular and Interventional Radiology,Affiliated Hospital of Medical College,Ningbo University,Ningbo,China;
9.Department of Radiology,Beilun District People’s Hospital of Ningbo,Ningbo,China;
10.Department of Intervention,First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China;
11.Department of Radiology,Lishui Central Hospital,Lishui Hospital of Zhejiang University,Fifth Affiliated Hospital of Wenzhou Medical University,Lishui,China;
12.Department of Intervention,Dongyang People’s Hospital,Dongyang,China;
13.Department of Intervention,Third Affiliated Hospital of Wenzhou Medical University,Ruian,China;
14.Department of Intervention,Jinhua Central Hospital,Jinhua,China;
15.Department of Hepatobiliary Surgery,Quzhou People’s Hospital,Quzhou,China;
16.Department of Intervention,Jiaxing First Hospital,Jiaxing,China;
17.Department of Intervention,Jiaxing Second Hospital,Jiaxing,China;
18.Interventional Center,Xinchang People’s Hospital,Shaoxing,China;
19.Department of Radiology,First Affiliated Hospital of Zhejiang Chinese Medical University,Hangzhou,China;
20.Division of Digestive Endoscopy,Yueqing City People’s Hospital,Yueqing,China;
21.Department of Radiology,Sir Run Run Shaw Hospital,Zhejiang University College of Medicine,Hangzhou,China;
22.Department of Intervention,Zhejiang Provincial People’s Hospital,Hangzhou,China;
23.Department of Hepatobiliary Surgery,Ningbo Medical Center,Lihuili Eastern Hospital,Ningbo,China;
24.Department of Intervention,Zhejiang Cancer Hospital,Hangzhou,China
推荐引用方式
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Peng, Zhiyi,Cao, Guohong,Hou, Qinming,et al. The Comprehensive Analysis of Efficacy and Safety of CalliSpheres (R) Drug-Eluting Beads Transarterial Chemoembolization in 367 Liver Cancer Patients: A Multiple-Center, Cohort Study[J]. ONCOLOGY RESEARCH,2020,28(3):249-271.
APA Peng, Zhiyi., Cao, Guohong., Hou, Qinming., Li, Ling., Ying, Shihong., ... & Shao, Guoliang. (2020). The Comprehensive Analysis of Efficacy and Safety of CalliSpheres (R) Drug-Eluting Beads Transarterial Chemoembolization in 367 Liver Cancer Patients: A Multiple-Center, Cohort Study. ONCOLOGY RESEARCH, 28(3), 249-271.
MLA Peng, Zhiyi,et al."The Comprehensive Analysis of Efficacy and Safety of CalliSpheres (R) Drug-Eluting Beads Transarterial Chemoembolization in 367 Liver Cancer Patients: A Multiple-Center, Cohort Study".ONCOLOGY RESEARCH 28.3(2020):249-271.

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