Challenges and opportunities in inflammatory bowel disease: from current therapeutic strategies to organoid-based models

doi:10.1007/s00011-024-01854-z

科研成果详情

题名	Challenges and opportunities in inflammatory bowel disease: from current therapeutic strategies to organoid-based models
作者	Kong, Lingjie1; Chen, Siyan2; Huang, Shenghao 1; Zheng, Anzhe 1; Gao, Sheng 3; Ye, Jianzhong4; Hua, Chunyan5
发表日期	2024-04
发表期刊	INFLAMMATION RESEARCH 影响因子和分区
语种	英语
原始文献类型	Review ; Early Access
关键词	Inflammatory bowel disease Etiopathogenesis Organoid Therapy
其他关键词	ACTIVE ULCERATIVE-COLITIS ; INTESTINAL-STEM-CELL ; FECAL MICROBIOTA TRANSPLANTATION ; INNATE LYMPHOID-CELLS ; CROHNS-DISEASE ; EPITHELIAL-CELLS ; BILE-ACIDS ; IN-VITRO ; SAFETY ; RESISTANCE
摘要	BackgroundInflammatory bowel disease (IBD) is an increasingly prevalent global health concern that has garnered substantial attention. However, the underlying mechanisms are still unclear and the current treatments have significant limitations. Intestinal organoids provide an in vitro model to explore the pathogenesis, test the therapeutic effects, and develop regenerative treatments as well as offer the potential to transform drug discovery of IBD.MethodsTo advance our understanding of the whole story of IBD spanning from the pathogenesis to the current therapeutic strategies and latest advancements, a comprehensive search of major databases including PubMed, Scopus, and Web of Science was conducted to retrieve original articles and reviews related to IBD, organoids, pathogenesis and therapy.ResultsThis review deciphers the etiopathogenesis and the current therapeutic approaches in the treatment of IBD. Notably, critical aspects of intestinal organoids in IBD, such as their potential applications, viability, cell renewal ability, and barrier functionality are highlighted. We also discuss the advances, limitations, and prospects of intestinal organoids for precision medicine.ConclusionThe latest strides made in research about intestinal organoids help elucidate intricate aspects of IBD pathogenesis, and pave the prospective avenues for novel therapeutic interventions.
资助项目	Science and Technology Plan Project of Wenzhou Municipality
出版者	SPRINGER BASEL AG
ISSN	1023-3830
EISSN	1420-908X
卷号	73 期号:4 页码:541-562
DOI	10.1007/s00011-024-01854-z
页数	22
WOS类目	Cell Biology ; Immunology
WOS研究方向	Cell Biology ; Immunology
WOS记录号	WOS:001159694200001
收录类别	SCIE ; PUBMED ; SCOPUS
在线发表日期	2024-02
URL	查看原文
PubMed ID	38345635
SCOPUSEID	2-s2.0-85184879615
通讯作者地址	[Gao, Sheng]Laboratory Animal Center,Wenzhou Medical University,Zhejiang,Wenzhou,325035,China ; [Ye, Jianzhong]Department of Clinical Laboratory,Key Laboratory of Clinical Laboratory Diagnosis and Translational Research of Zhejiang Province,The First Affiliated Hospital of Wenzhou Medical University,Zhejiang,Wenzhou,China ; [Hua, Chunyan]School of Basic Medical Sciences,Wenzhou Medical University,Zhejiang,Wenzhou,325035,China
Scopus学科分类	Immunology;Pharmacology
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/207118
专题	温州医科大学基础医学院（机能实验教学中心）附属第一医院实验动物中心仁济学院_眼视光、生物医学工程学部
通讯作者	Gao, Sheng; Ye, Jianzhong; Hua, Chunyan
作者单位	1.School of the 2nd Clinical Medical Sciences,Wenzhou Medical University,Zhejiang,Wenzhou,325035,China; 2.School of Ophthalmology & amp; Optometry,School of Biomedical Engineering,Wenzhou Medical University,Zhejiang,Wenzhou,325035,China; 3.Laboratory Animal Center,Wenzhou Medical University,Zhejiang,Wenzhou,325035,China; 4.Department of Clinical Laboratory,Key Laboratory of Clinical Laboratory Diagnosis and Translational Research of Zhejiang Province,The First Affiliated Hospital of Wenzhou Medical University,Zhejiang,Wenzhou,China; 5.School of Basic Medical Sciences,Wenzhou Medical University,Zhejiang,Wenzhou,325035,China
第一作者单位	温州医科大学
通讯作者单位	实验动物中心; 附属第一医院; 基础医学院（机能实验教学中心）
第一作者的第一单位	温州医科大学
推荐引用方式 GB/T 7714	Kong, Lingjie,Chen, Siyan,Huang, Shenghao,et al. Challenges and opportunities in inflammatory bowel disease: from current therapeutic strategies to organoid-based models[J]. INFLAMMATION RESEARCH,2024,73(4):541-562.
APA	Kong, Lingjie., Chen, Siyan., Huang, Shenghao., Zheng, Anzhe., Gao, Sheng., ... & Hua, Chunyan. (2024). Challenges and opportunities in inflammatory bowel disease: from current therapeutic strategies to organoid-based models. INFLAMMATION RESEARCH, 73(4), 541-562.
MLA	Kong, Lingjie,et al."Challenges and opportunities in inflammatory bowel disease: from current therapeutic strategies to organoid-based models".INFLAMMATION RESEARCH 73.4(2024):541-562.