Relationship between vaginal microecology and human papillomavirus infection as well as cervical intraepithelial neoplasia in 2,147 women from Wenzhou, the southeast of China

doi:10.3389/fonc.2023.1306376

科研成果详情

题名	Relationship between vaginal microecology and human papillomavirus infection as well as cervical intraepithelial neoplasia in 2,147 women from Wenzhou, the southeast of China
作者	Zang, Lejing 1; Feng, Renqian2; Huang, Yitong 1; Huang, Jiahe 1; Hu, Yan2
发表日期	2024-01-03
发表期刊	FRONTIERS IN ONCOLOGY 影响因子和分区
语种	英语
原始文献类型	Article
关键词	vaginal microecology human papillomavirus cervical intraepithelial neoplasia cervical cancer probiotics
其他关键词	LESIONS ; CANCER
摘要	Objective The female reproductive tract is a significant microecological region, and its micro-environment can directly affect women's cervical health. This research aimed to investigate the effect of vaginal microecology on human papillomavirus (HPV) infection and cervical intraepithelial neoplasia(CIN).Methods A retrospective cohort study enrolling 2,147 women who underwent a colposcopic examination between August 2021 and August 2022 was conducted. The relationship between vaginal microecology and HPV infection as well as cervical lesions were assessed using the chi-square test, univariate and multivariate logistic regression analyses, and Cochran-Armitage trend test.Results HPV infection was linked to the imbalance of vaginal microecology [odds ratio (OR)=3.00, 95% confidence interval (CI)=1.66-5.43; P<0.001]. Clue cell (OR=1.59, 95% CI=0.99-2.54; P=0.054) and sialidase (OR=1.54, 95% CI=1.01-2.35; P<0.046) were considered as significant risk factors for HPV infection. Further analysis showed that vaginal microecological disorder was more likely to be detected in patients infected with HPV 16/18 subtypes (OR=9.86, 95% CI=2.37-41.80; P=0.002). Although there was no significant correlation between the incidence of vaginal microecological disorder and the severity of cervical lesions (P > 0.05), the proportions of abnormal PH value (OR=2.6, 95% CI=1.63-10.42; P=0.001) and abnormal vaginal cleanliness (OR=2.6, 95% CI=1.36-4.0; P= 0.004) increased as the histological stage progressed.Conclusion Vaginal microecology associates with HPV infection and the progression of cervical lesions. Detection of vaginal secretion may contribute to the development of targets for micro-environmental modulation with probiotics and the reduction of the incidence of cervical cancer.
资助项目	Wenzhou Central Hospital; First Affiliated Hospital of Wenzhou Medical University
出版者	FRONTIERS MEDIA SA
ISSN	2234-943X
卷号	13
DOI	10.3389/fonc.2023.1306376
页数	8
WOS类目	Oncology
WOS研究方向	Oncology
WOS记录号	WOS:001143605300001
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	38234401
SCOPUSEID	2-s2.0-85182483206
通讯作者地址	[Hu, Yan]Department of Gynecology,First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China
Scopus学科分类	Oncology;Cancer Research
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/207114
专题	第一临床医学院（信息与工程学院）、附属第一医院_妇产科学_妇科附属第一医院
通讯作者	Hu, Yan
作者单位	1.Department of Gynecological Oncology,Wenzhou Central Hospital,Wenzhou,China; 2.Department of Gynecology,First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China
通讯作者单位	附属第一医院
推荐引用方式 GB/T 7714	Zang, Lejing,Feng, Renqian,Huang, Yitong,et al. Relationship between vaginal microecology and human papillomavirus infection as well as cervical intraepithelial neoplasia in 2,147 women from Wenzhou, the southeast of China[J]. FRONTIERS IN ONCOLOGY,2024,13.
APA	Zang, Lejing, Feng, Renqian, Huang, Yitong, Huang, Jiahe, & Hu, Yan. (2024). Relationship between vaginal microecology and human papillomavirus infection as well as cervical intraepithelial neoplasia in 2,147 women from Wenzhou, the southeast of China. FRONTIERS IN ONCOLOGY, 13.
MLA	Zang, Lejing,et al."Relationship between vaginal microecology and human papillomavirus infection as well as cervical intraepithelial neoplasia in 2,147 women from Wenzhou, the southeast of China".FRONTIERS IN ONCOLOGY 13(2024).