Degradable Zn-5Ce alloys with high strength, suitable degradability, good cytocompatibility, and osteogenic differentiation fabricated via hot-rolling, hot-extrusion, and high-pressure torsion for potential load-bearing bone-implant application

doi:10.1016/j.jmrt.2023.12.098

科研成果详情

题名	Degradable Zn-5Ce alloys with high strength, suitable degradability, good cytocompatibility, and osteogenic differentiation fabricated via hot-rolling, hot-extrusion, and high-pressure torsion for potential load-bearing bone-implant application
作者	Tong, Xian1,2,3; Hong, Xinhua2; Chen, Liang2; Zhang, Yaru2; Wang, Yilin2; Chen, Yuge2; Zhu, Yunpeng2; Wang, Cheng2; Zhu, Li 2; Lin, Jixing2; Huang, Shengbin2; Ma, Jianfeng2; Luo, Peng1
发表日期	2024-01
发表期刊	JOURNAL OF MATERIALS RESEARCH AND TECHNOLOGY-JMR&T 影响因子和分区
语种	英语
原始文献类型	Article ; Early Access
关键词	Zn-RE alloy High-pressure torsion Corrosion behavior Bio-tribological behavior Biocompatibility
其他关键词	SEVERE PLASTIC-DEFORMATION ; MECHANICAL-PROPERTIES ; RARE-EARTH ; CORROSION BEHAVIOR ; GRAIN-REFINEMENT ; ZN ; MAGNESIUM ; MICROSTRUCTURE ; DUCTILITY ; ELEMENTS
摘要	Zinc (Zn)-based alloys are considered the next-generation biodegradable material for promising bone-implant devices due to their good degradability, formability, and functionality. Nevertheless, the as-cast Zn alloys showed a low strength-toughness, making it challenging to meet the mechanical properties requirements for high-load-bearing bone implants due to their hexagonal close-packed structure, coarse grain size, and less sliding system. Herein, we have developed biodegradable Zn-5Ce alloys by cerium (Ce) alloying followed by hot-rolling, hot-extrusion, and high-pressure torsion (HPT), respectively, for potential bone-implant application. Mechanical testing revealed that the HPT sample exhibited the best mechanical performance matching among the Zn-5Ce samples with a high ultimate tensile strength of-345 MPa, yield strength of-230 MPa, a moderate elongation of-11.4%, and macro-hardness of-96.6 HB. Electrochemical corrosion and static immersion testing revealed that the HPT sample showed the highest electrochemical corrosion rate of-416 mu m/y and degradation rate of-43.8 mu m/y in Hanks' solution among the Zn-5Ce samples, which is suitable for degradation rate requirements for bone-implant application. Bio-tribological testing revealed that the HPT sample showed high bio-tribological properties matching in Hanks' solution with the lowest friction coefficients of-0.530 and moderate wear loss of-2.2 mg. Cytocompatibility and osteogenic differentiation assessment revealed that the diluted extract of the HPT sample showed the highest cytocompatibility towards 3T3 and MG-63 cells and osteogenic differentiation performance towards 3T3 cells among the most diluted extracts. Accordingly, the HPT Zn-5Ce sample is ex-pected to be used for high-load-bearing degradable bone-implant devices, including bone fixation and guided bone regeneration systems.
资助项目	Zhejiang Public Welfare Technology Application Research Project of China [LGF22H140008, LTGY23H140002]
出版者	ELSEVIER
ISSN	2238-7854
EISSN	2214-0697
卷号	28 页码:1752-1763
DOI	10.1016/j.jmrt.2023.12.098
页数	12
WOS类目	Materials Science, Multidisciplinary ; Metallurgy & Metallurgical Engineering
WOS研究方向	Materials Science ; Metallurgy & Metallurgical Engineering
WOS记录号	WOS:001141246300001
收录类别	SCIE ; SCOPUS
URL	查看原文
SCOPUSEID	2-s2.0-85180406670
TOP期刊	TOP期刊
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/207113
专题	第二临床医学院、附属第二医院、育英儿童医院附属第二医院口腔医学院、附属口腔医院口腔医学院、附属口腔医院_口腔医学研究所
通讯作者	Huang, Shengbin; Ma, Jianfeng; Luo, Peng
作者单位	1.Wenzhou Med Coll, Dept Orthopaed, Affiliated Hosp 2, Wenzhou 325027, Peoples R China; 2.Wenzhou Med Univ, Sch & Hosp Stomatol, Inst Stomatol, Wenzhou 325027, Peoples R China; 3.Xiangtan Univ, Sch Mat Sci & Engn, Xiangtan 411105, Peoples R China
第一作者单位	附属第二医院; 第二临床医学院，附属第二医院、育英儿童医院; 口腔医学院、附属口腔医院; 口腔医学研究所
第一作者的第一单位	附属第二医院
推荐引用方式 GB/T 7714	Tong, Xian,Hong, Xinhua,Chen, Liang,et al. Degradable Zn-5Ce alloys with high strength, suitable degradability, good cytocompatibility, and osteogenic differentiation fabricated via hot-rolling, hot-extrusion, and high-pressure torsion for potential load-bearing bone-implant application[J]. JOURNAL OF MATERIALS RESEARCH AND TECHNOLOGY-JMR&T,2024,28:1752-1763.
APA	Tong, Xian., Hong, Xinhua., Chen, Liang., Zhang, Yaru., Wang, Yilin., ... & Luo, Peng. (2024). Degradable Zn-5Ce alloys with high strength, suitable degradability, good cytocompatibility, and osteogenic differentiation fabricated via hot-rolling, hot-extrusion, and high-pressure torsion for potential load-bearing bone-implant application. JOURNAL OF MATERIALS RESEARCH AND TECHNOLOGY-JMR&T, 28, 1752-1763.
MLA	Tong, Xian,et al."Degradable Zn-5Ce alloys with high strength, suitable degradability, good cytocompatibility, and osteogenic differentiation fabricated via hot-rolling, hot-extrusion, and high-pressure torsion for potential load-bearing bone-implant application".JOURNAL OF MATERIALS RESEARCH AND TECHNOLOGY-JMR&T 28(2024):1752-1763.