Altered mitochondrial lymphocyte in overweight schizophrenia patients treated with atypical antipsychotics and its association with cognitive function

doi:10.3389/fimmu.2023.1325495

科研成果详情

题名	Altered mitochondrial lymphocyte in overweight schizophrenia patients treated with atypical antipsychotics and its association with cognitive function
作者	Zhang, Yaoyao1; Tang, Wei 1; Tang, Bei 2; Fan, Kaili 3; Zhao, Ke4; Fang, Xinyu 5; Lin, Hui 6
发表日期	2024-01-03
发表期刊	FRONTIERS IN IMMUNOLOGY 影响因子和分区
语种	英语
原始文献类型	Article
关键词	schizophrenia atypical antipsychotic medications mitochondrial lymphocyte overweight cognition
其他关键词	NEGATIVE SYNDROME SCALE ; BODY-MASS INDEX ; PERMEABILITY TRANSITION ; DYSFUNCTION ; INFLAMMATION ; OBESITY ; RISK ; INDIVIDUALS ; AGE
摘要	Objective Increasing evidence indicated that schizophrenia and obesity are associated with altered mitochondrial and immune function. In this study, we investigated the levels of CRP (C-reactive protein) and mitochondrial lymphocytes in chronically treated schizophrenia patients with atypical antipsychotic medications and further explored the relationship between mitochondrial lymphocyte and weight gain as well as cognitive function in these patients.Methods We evaluated the mitochondrial lymphocyte count of 97 patients (53 overweight, 44 non-overweight) and 100 healthy controls using mitochondrial fluorescence staining and flow cytometry (NovoCyte, Agilent Technologies, US). The serum CRP was measured by high-sensitivity enzyme-linked immunosorbent assay (ELISA). Clinical symptoms and cognitive function of the patients were assessed using the Positive and Negative Syndrome Scale (PANSS) and the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS).Results The results showed that mitochondrial lymphocyte counts of CD3+ T, CD3+CD4+ T, and CD3+CD8+ T cells in schizophrenia patients were higher than in the control group (p < 0.05). Additionally, overweight patients had significantly higher mitochondrial lymphocyte counts of CD3+ T and CD3+CD4+ T cells compared to schizophrenia patients with normal weight. Stratified analysis by gender revealed that there was a statistically significant difference in CD3+CD4+ mitochondrial lymphocyte count in male patients (p = 0.014) and a marginal trend toward significance in female patients (p = 0.058). Furthermore, the mitochondrial lymphocyte counts of CD3+ T and CD3+CD4+ T cells, as well as CRP levels, were positively correlated with BMI in schizophrenia patients, but the mitochondrial lymphocyte counts of CD3+CD4+ T cells were negatively correlated with the language scale in the RBANS.Conclusion Our study results provide evidence for the association between altered mitochondrial T lymphocyte and weight gain as well as cognitive impairment in schizophrenia patients treated with atypical antipsychotic medications.
资助项目	Traditional Chinese Medicine Program of Zhejiang Province [2022KY1211]; Medical Science and Technology Development Foundation, Nanjing Department of Health [YKK20090]
出版者	FRONTIERS MEDIA SA
ISSN	1664-3224
卷号	14
DOI	10.3389/fimmu.2023.1325495
页数	10
WOS类目	Immunology
WOS研究方向	Immunology
WOS记录号	WOS:001143399400001
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	3823514
SCOPUSEID	2-s2.0-85182388804
通讯作者地址	[Fang, Xinyu]Department of Psychiatry,the Affiliated Brain Hospital of Nanjing Medical University,Jiangsu,Nanjing,China ; [Lin, Hui]Department of Psychiatry,The Second People`s Hospital of YuHuan,Zhejiang,Taizhou,China
Scopus学科分类	Immunology and Allergy;Immunology
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/207067
专题	其他_附属康宁医院（温州市康宁医院）第一临床医学院（信息与工程学院）、附属第一医院_精神病与精神卫生学
通讯作者	Fang, Xinyu; Lin, Hui
作者单位	1.Department of Psychiatry,The Affiliated Kangning Hospital of Wenzhou Medical University Zhejiang Provincial Clinical Research Center for Mental Disorder,Zhejiang,Wenzhou,China; 2.Department of Education,Children’s Hospital of Nanjing Medical University,Jiangsu,Nanjing,China; 3.Department of Psychiatry,Wenzhou Seventh People’s Hospital,Zhejiang,Wenzhou,China; 4.Department of Psychiatry,Wenzhou Medical University,Zhejiang,Wenzhou,China; 5.Department of Psychiatry,the Affiliated Brain Hospital of Nanjing Medical University,Jiangsu,Nanjing,China; 6.Department of Psychiatry,The Second People`s Hospital of YuHuan,Zhejiang,Taizhou,China
第一作者单位	其他_附属康宁医院（温州市康宁医院）
第一作者的第一单位	其他_附属康宁医院（温州市康宁医院）
推荐引用方式 GB/T 7714	Zhang, Yaoyao,Tang, Wei,Tang, Bei,et al. Altered mitochondrial lymphocyte in overweight schizophrenia patients treated with atypical antipsychotics and its association with cognitive function[J]. FRONTIERS IN IMMUNOLOGY,2024,14.
APA	Zhang, Yaoyao., Tang, Wei., Tang, Bei., Fan, Kaili., Zhao, Ke., ... & Lin, Hui. (2024). Altered mitochondrial lymphocyte in overweight schizophrenia patients treated with atypical antipsychotics and its association with cognitive function. FRONTIERS IN IMMUNOLOGY, 14.
MLA	Zhang, Yaoyao,et al."Altered mitochondrial lymphocyte in overweight schizophrenia patients treated with atypical antipsychotics and its association with cognitive function".FRONTIERS IN IMMUNOLOGY 14(2024).