Inhibition of TAF1B impairs ribosome biosynthesis and suppresses cell proliferation in stomach adenocarcinoma through promoting c-MYC mRNA degradation

doi:10.1016/j.heliyon.2023.e23167

科研成果详情

题名	Inhibition of TAF1B impairs ribosome biosynthesis and suppresses cell proliferation in stomach adenocarcinoma through promoting c-MYC mRNA degradation
作者	Chen, Hang-fei 1,2; Li, Zhang-ping 3; Wu, Qi 1; Yu, Chun4; Yan, Jing-Yi5; Bai, Yong-feng 1; Zhu, Sheng-mei 1; Qian, Mao-xiang 6; Liu, Ming 1; Xu, Li-feng1; Peng, Zheng7; Zhang, Feng 1,2
发表日期	2024-01-15
发表期刊	HELIYON 影响因子和分区
语种	英语
原始文献类型	Article ; Early Access ; Journal Article
关键词	TAF1B Stomach adenocarcinoma c-MYC Nucleolar stress Ribosome biosynthesis RNA polymerase I
其他关键词	POLYMERASE-I ; PROTEINS L5 ; CANCER ; TRANSCRIPTION ; BIOGENESIS ; NUCLEOLUS ; L11 ; TBP ; DISEASE ; BINDING
摘要	Hyperactivation of ribosome biosynthesis (RiBi) is a hallmark of cancer, and targeting ribosome biogenesis has emerged as a potential therapeutic strategy. The depletion of TAF1B, a major component of selectivity factor 1 (SL1), disrupts the pre-initiation complex, preventing RNA polymerase I from binding ribosomal DNA and inhibiting the hyperactivation of RiBi. Here, we investigate the role of TAF1B, in regulating RiBi and proliferation in stomach adenocarcinoma (STAD). We disclosed that the overexpression of TAF1B correlates with poor prognosis in STAD, and found that knocking down TAF1B effectively inhibits STAD cell proliferation and survival in vitro and in vivo. TAF1B knockdown may also induce nucleolar stress, and promote c-MYC degradation in STAD cells. Furthermore, we demonstrate that TAF1B depletion impairs rRNA gene transcription and processing, leading to reduced ribosome biogenesis. Collectively, our findings suggest that TAF1B may serve as a potential therapeutic target for STAD and highlight the importance of RiBi in cancer progression.
资助项目	Quzhou Technology Projects [2022K46, 2019K36, 2018K20]; Natural Science Foundation of China [81502304]; Natural Science Foundation of Zhejiang Province [LQ19H160002]; Medical and Health Technology Projects of Zhejiang Province [2017KY696, 2019PY089]; Chinese Medicine Science Foundation of Zhejiang Province [2021ZB328]
出版者	CELL PRESS
ISSN	2405-8440
EISSN	2405-8440
卷号	10 期号:1
DOI	10.1016/j.heliyon.2023.e23167
页数	12
WOS类目	Multidisciplinary Sciences
WOS研究方向	Science & Technology - Other Topics
WOS记录号	WOS:001143892200001
收录类别	SCIE ; PUBMED ; SCOPUS
在线发表日期	2023-12
URL	查看原文
PubMed ID	38169774
SCOPUSEID	2-s2.0-85179822789
通讯作者地址	[Zhang, Feng]The Joint Innovation Center for Engineering in Medicine,the Quzhou Affiliated Hospital of Wenzhou Medical University,Quzhou People's Hospital,Quzhou,324000,China ; [Peng, Zheng]Department of Radiation Oncology,the Quzhou Affiliated Hospital of Wenzhou Medical University,Quzhou People's Hospital,Quzhou,324000,China
Scopus学科分类	Multidisciplinary
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/207056
专题	其他_温州医科大学附属衢州医院附属第一医院第一临床医学院（信息与工程学院）、附属第一医院_急诊医学
通讯作者	Peng, Zheng; Zhang, Feng
作者单位	1.The Joint Innovation Center for Engineering in Medicine,the Quzhou Affiliated Hospital of Wenzhou Medical University,Quzhou People's Hospital,Quzhou,324000,China; 2.The 2nd Clinical Medical College,Zhejiang Chinese Medical University,Hangzhou,310053,China; 3.Department of Emergency Medicine,the Quzhou Affiliated Hospital of Wenzhou Medical University,Quzhou People's Hospital,Quzhou,324000,China; 4.Department of Gastroenterology,the Quzhou Affiliated Hospital of Wenzhou Medical University,Quzhou People's Hospital,Quzhou,324000,China; 5.The First Affiliated Hospital of Wenzhou Medical University,Zhejiang,Wenzhou,325000,China; 6.Institute of Pediatrics and Department of Hematology and Oncology,National Children's Medical Center,Children's Hospital of Fudan University,Institutes of Biomedical Sciences,Fudan University,Shanghai,200032,China; 7.Department of Radiation Oncology,the Quzhou Affiliated Hospital of Wenzhou Medical University,Quzhou People's Hospital,Quzhou,324000,China
第一作者单位	其他_温州医科大学附属衢州医院
通讯作者单位	其他_温州医科大学附属衢州医院
第一作者的第一单位	其他_温州医科大学附属衢州医院
推荐引用方式 GB/T 7714	Chen, Hang-fei,Li, Zhang-ping,Wu, Qi,et al. Inhibition of TAF1B impairs ribosome biosynthesis and suppresses cell proliferation in stomach adenocarcinoma through promoting c-MYC mRNA degradation[J]. HELIYON,2024,10(1).
APA	Chen, Hang-fei., Li, Zhang-ping., Wu, Qi., Yu, Chun., Yan, Jing-Yi., ... & Zhang, Feng. (2024). Inhibition of TAF1B impairs ribosome biosynthesis and suppresses cell proliferation in stomach adenocarcinoma through promoting c-MYC mRNA degradation. HELIYON, 10(1).
MLA	Chen, Hang-fei,et al."Inhibition of TAF1B impairs ribosome biosynthesis and suppresses cell proliferation in stomach adenocarcinoma through promoting c-MYC mRNA degradation".HELIYON 10.1(2024).