题名 | Efficacy and safety of CalliSpheres (R) drug-eluting beads transarterial chemoembolization in patients with secondary liver cancer: a preliminary result from CTILC study |
作者 | Wu, Xia1; Ying, Shihong2; Huang, Jing3; Shi, Changsheng4
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发表日期 | 2019-08 |
发表期刊 | TRANSLATIONAL CANCER RESEARCH 影响因子和分区 |
语种 | 英语 |
原始文献类型 | Article |
关键词 | Drug-eluting beads transarterial chemoembolization (DEB-TACE) secondary liver cancer treatment response overall survival liver function safety |
其他关键词 | HEPATOCELLULAR-CARCINOMA ; METASTASIS ; MICROSPHERES |
摘要 | Background: This study aimed to assess the treatment response, short-term overall survival (OS) and safety profiles of drug-eluting beads transarterial chemoembolization (DEB-TACE) in patients with secondary liver cancer. Methods: Fifty-five patients with secondary liver cancer underwent DEB-TACE were enrolled in this prospective cohort study. Treatment response was assessed by modified Response Evaluation Criteria in Solid Tumors (mRECIST). OS was calculated from the time of DEB-TACE operation until the date of death. Results: The complete response (CR) and objective response rate (ORR) at 1-3 months post DEB-TACE were 12.7% and 67.3 %. Mean OS was 383 d (95% CI: 360-406), and 6-month OS rate was 93.4%+/- 3.7%. Subgroup analysis revealed previous conventional TACE (cTACE) treatment was correlated with worse ORR (P=0.028), and it was a risk factor for ORR achievement (P=0.021). As for liver function, the percentages of abnormal TP (P=0.031), TBIL (P=0.022), ALT (P=0.002) and AST (P=0.035) were increased at 1 week post DEB-TACE compared to baseline, while these four indexes returned to baseline (all P>0.05) at 1-3 months post DEB-TACE. As to safety profiles, 41 (66.1%), 28 (45.2%), 17 (27.4%), 8 (12.9%) and 6 (9.7%) cases had pain, vomiting, fever, nausea and other adverse events (AEs) respectively during DEB-TACE operation, while 26 (41.9%), 9 (14.5%), 8 (12.9%), 4 (6.5%), 1 (1.6%) and 2 (3.2%) cases had pain, fever, vomiting, nausea, bone marrow toxicity and other AEs respectively at 1 month after DEB-TACE operation. Conclusions: DEB-TACE was efficient and well tolerated in treating patients with secondary liver cancer. |
资助项目 | National Nature Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81371658]; Zhejiang Provincial Natural Science FoundationNatural Science Foundation of Zhejiang Province [LZ18H180001, LY18H180002]; Medical Health Science and Technology Project of Zhejiang Provincial Health Commission [2016151760] |
出版者 | AME PUBL CO |
出版地 | SHATIN |
ISSN | 2218-676X |
EISSN | 2219-6803 |
卷号 | 8期号:4页码:1199-1216 |
DOI | 10.21037/tcr.2019.06.44 |
页数 | 18 |
WOS类目 | Oncology |
WOS研究方向 | Oncology |
WOS记录号 | WOS:000484233000019 |
收录类别 | SCIE ; PUBMED ; SCOPUS |
URL | 查看原文 |
PubMed ID | 35116862 |
PMC记录号 | PMC8797412 |
SCOPUSEID | 2-s2.0-85073024689 |
通讯作者地址 | [Hu, Hongjie]Department of Radiology,Sir Run Run Shaw Hospital,Zhejiang University College of Medicine,3 Qingchun East Road,Hangzhou,310016,China |
Scopus学科分类 | Oncology;Radiology, Nuclear Medicine and Imaging;Cancer Research |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | https://kms.wmu.edu.cn/handle/3ETUA0LF/20694 |
专题 | 其他_附属第三医院(瑞安市人民医院) 附属第一医院 其他_附属第五医院(丽水市中心医院) |
通讯作者 | Hu, Hongjie |
作者单位 | 1.Department of Radiology,Sir Run Run Shaw Hospital,Zhejiang University College of Medicine,3 Qingchun East Road,Hangzhou,310016,China; 2.Department of Radiology,First Affiliated Hospital,College of Medicine,Zhejiang University,Hangzhou,310003,China; 3.Department of Hepatobiliary Surgery,Ningbo Medical Center,Lihuili Eastern Hospital,Ningbo,315040,China; 4.Department of Intervention,Third Affiliated Hospital of Wenzhou Medical University,Ruian,325200,China; 5.Department of Radiology,Lishui Central Hospital,Lishui Hospital of Zhejiang University,Fifth Affiliated Hospital of Wenzhou Medical University,Lishui,323000,China; 6.Hepatobiliary and Pancreatic Interventional Treatment Center,Division of Hepatobiliary and Pancreatic Surgery,First Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou,310003,China; 7.Department of Radiology,First Affiliated Hospital of Zhejiang Chinese Medical University,Hangzhou,310006,China; 8.Department of Intervention,Zhejiang Provincial People’s Hospital,Hangzhou,310014,China; 9.Department of Intervention,First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China; 10.Department of Radiology,Hangzhou Cancer Hospital,Hangzhou,310002,China; 11.Department of Intervention,Zhejiang Cancer Hospital,Hangzhou,310022,China; 12.Department of Vascular and Interventional Radiology,Affiliated Hospital of Medical College of Ningbo University,Ningbo,315020,China; 13.Department of Radiology,Xixi Hospital of Hangzhou,Hangzhou 6th People’s Hospital,Hangzhou,310023,China; 14.Department of Intervention,Jiaxing Second Hospital,Jiaxing,314099,China; 15.Department of Radiology,Beilun District People’s Hospital of Ningbo,Ningbo,315800,China; 16.Interventional Center,Xinchang People’s Hospital,Shaoxing,312500,China; 17.Department of Radiology,Shulan (Hangzhou) Hospital,Zhejiang University International Hospital,Hangzhou,310000,China; 18.Department of Intervention,Dong Yang People’s Hospital,Dongyang,322100,China; 19.Department of Liver Oncology,Ningbo No.2 Hospital,Ningbo,315010,China; 20.Division of Digestive Endoscopy,Yueqing City People’s Hospital,Yueqing,325600,China; 21.Department of Intervention,Jiaxing First Hospital,Jiaxing,314033,China; 22.Department of Radiology,Taizhou Hospital of Zhejiang Province,Linhai,317000,China; 23.Department of Hepatobiliary Surgery,Quzhou People’s Hospital,Quzhou,324000,China; 24.Department of Intervention,Jinhua Central Hospital,351 Mingyue Street,Jinhua,321000,China |
推荐引用方式 GB/T 7714 | Wu, Xia,Ying, Shihong,Huang, Jing,et al. Efficacy and safety of CalliSpheres (R) drug-eluting beads transarterial chemoembolization in patients with secondary liver cancer: a preliminary result from CTILC study[J]. TRANSLATIONAL CANCER RESEARCH,2019,8(4):1199-1216. |
APA | Wu, Xia., Ying, Shihong., Huang, Jing., Shi, Changsheng., Ji, Jiansong., ... & Guo, Xiaohua. (2019). Efficacy and safety of CalliSpheres (R) drug-eluting beads transarterial chemoembolization in patients with secondary liver cancer: a preliminary result from CTILC study. TRANSLATIONAL CANCER RESEARCH, 8(4), 1199-1216. |
MLA | Wu, Xia,et al."Efficacy and safety of CalliSpheres (R) drug-eluting beads transarterial chemoembolization in patients with secondary liver cancer: a preliminary result from CTILC study".TRANSLATIONAL CANCER RESEARCH 8.4(2019):1199-1216. |
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