LINC01133 can induce acquired ferroptosis resistance by enhancing the FSP1 mRNA stability through forming the LINC01133-FUS-FSP1 complex

doi:10.1038/s41419-023-06311-z

科研成果详情

题名	LINC01133 can induce acquired ferroptosis resistance by enhancing the FSP1 mRNA stability through forming the LINC01133-FUS-FSP1 complex
作者	Wang, Shaowen 1,2; Chen, Jionghuang 3; Li, Pengping 4; Chen, Yangchao 1,5
发表日期	2023-11-25
发表期刊	CELL DEATH & DISEASE 影响因子和分区
语种	英语
原始文献类型	Article ; Journal Article
其他关键词	CANCER
摘要	Due to a lack of research on the critical non-coding RNAs in regulating ferroptosis, our study aimed to uncover the crucial ones involved in the process. We found that LINC01133 could make pancreatic cancer cells more resistant to ferroptosis. A higher expression of LINC01133 was associated with a higher IC50 of sorafenib in clinical samples. Furthermore, we discovered that LINC01133 induced this process through enhancing the mRNA stability of FSP1. CEBPB was the transcription factor to increase the expression of LINC01133. A higher CEBPB could also indicate a higher IC50 of sorafenib in patients with cancer. Moreover, we confirmed that LINC01133 could form a triple complex with FUS and FSP1 to increase the mRNA stability of FSP1.
资助项目	General Research Fund, Research Grants Council of Hong Kong [CUHK14171217, CUHK14120618 and CUHK14120419 to Y.C.]; National Natural Science Foundation of China [32270618 and 81672323 to Y.C.] [CUHK14171217, CUHK14120618, CUHK14120419]; General Research Fund, Research Grants Council of Hong Kong [32270618, 81672323]; National Natural Science Foundation of China; Research Matching Grant from UGC; CUHK; School of Biomedical Sciences at the Chinese University of Hong Kong
出版者	SPRINGERNATURE
ISSN	2041-4889
卷号	14 期号:11
DOI	10.1038/s41419-023-06311-z
页数	14
WOS类目	Cell Biology
WOS研究方向	Cell Biology
WOS记录号	WOS:001107848700003
收录类别	SCIE ; SCOPUS ; PUBMED
URL	查看原文
PubMed ID	38007473
SCOPUSEID	2-s2.0-85177764613
通讯作者地址	[Chen, Yangchao]School of Biomedical Sciences,Faculty of Medicine,The Chinese University of Hong Kong,NT,Shatin,Hong Kong
Scopus学科分类	Immunology;Cellular and Molecular Neuroscience;Cell Biology;Cancer Research
TOP期刊	TOP期刊
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/206870
专题	其他_附属萧山医院（杭州市萧山区第一人民医院）
通讯作者	Chen, Yangchao
作者单位	1.School of Biomedical Sciences,Faculty of Medicine,The Chinese University of Hong Kong,NT,Shatin,Hong Kong; 2.Neuromedicine Center,The University of Hong Kong-Shenzhen Hospital,Guangdong,Shenzhen,518053,China; 3.Department of General Surgery,Sir Run Run Shaw Hospital,Zhejiang University School of Medicine,Hangzhou,310000,China; 4.Department of Thyroid & Breast Surgery,The First People’s Hospital of Xiaoshan District,Xiaoshan Affiliated Hospital of Wenzhou Medical University,Zhejiang,Hangzhou,China; 5.Shenzhen Research Institute,The Chinese University of Hong Kong,Shenzhen,518087,China
推荐引用方式 GB/T 7714	Wang, Shaowen,Chen, Jionghuang,Li, Pengping,et al. LINC01133 can induce acquired ferroptosis resistance by enhancing the FSP1 mRNA stability through forming the LINC01133-FUS-FSP1 complex[J]. CELL DEATH & DISEASE,2023,14(11).
APA	Wang, Shaowen, Chen, Jionghuang, Li, Pengping, & Chen, Yangchao. (2023). LINC01133 can induce acquired ferroptosis resistance by enhancing the FSP1 mRNA stability through forming the LINC01133-FUS-FSP1 complex. CELL DEATH & DISEASE, 14(11).
MLA	Wang, Shaowen,et al."LINC01133 can induce acquired ferroptosis resistance by enhancing the FSP1 mRNA stability through forming the LINC01133-FUS-FSP1 complex".CELL DEATH & DISEASE 14.11(2023).