A Prospective Randomized Multicenter Controlled Trial on Salvianolate for Treatment of Unstable Angina Pectoris in A Chinese Elderly Population

doi:10.1007/s11655-019-2710-x

科研成果详情

题名	A Prospective Randomized Multicenter Controlled Trial on Salvianolate for Treatment of Unstable Angina Pectoris in A Chinese Elderly Population
作者	Cui, Hua 1; Li, Xiao-ying 1; Gao, Xue-wen 2; Lu, Xiang 3; Wu, Xiu-ping 4; Wang, Xiao-fei 5; Zheng, Xiang-qing 6; Huang, Kui 7; Liu, Feng 8; Luo, Zhi 9; Yuan, Hui-shu 10; Sun, Gang 11; Kong, Jian 12; Du, Xiao-hong13; Zheng, Jin 1; Liu, Hong-ying 14; Zhang, Wen-ju 15
发表日期	2019-10
发表期刊	CHINESE JOURNAL OF INTEGRATIVE MEDICINE 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Salvianolate unstable angina pectoris elderly efficacy
其他关键词	ACUTE CORONARY SYNDROME ; ASSOCIATION TASK-FORCE ; AMERICAN-COLLEGE ; DEPSIDE SALTS ; MILTIORRHIZA ; QUESTIONNAIRE ; INTERVENTION ; GUIDELINES ; MANAGEMENT ; ADULTS
摘要	Objective To evaluate the efficacy and safety of salvianolate in elderly patients with unstable angina pectoris (UAP). Methods A prospective double-blind randomized placebo-controlled multicenter trial in elderly patients with UAP from 13 third-grade class-A hospitals in China was performed. A total of 318 patients were randomly allocated in a 1:1 ratio to an experimental group (160 patients) and a control group (158 patients). The experimental group was treated with salvianolate for 14 days on the basis of conventional medicine, and the control group was given a placebo for 14 days with the same criteria. Follow-up was lasted 28 days in both groups. The primary endpoint was biweekly frequency of angina pectoris attacks. The secondary endpoints included biweekly dosage of nitroglycerin, the Seattle Angina Questionnaire, angina pectoris severity and duration, myocardial injury markers, high-sensitivity C-reactive protein (hs-CRP) and N-terminal pro-B-type natriuretic peptide (NT-proBNP), as well as major adverse cardiovascular events (MACEs). Safety was assessed according to adverse events and serious adverse events. Results Baseline characteristics were similar between treatment groups. Compared with those in the control group, the frequency of biweekly angina attacks (2.92 vs . 4.08, P=0.025), the biweekly dosage of nitroglycerin, as well as the severity and duration of angina attacks (P<0.01) were reduced by salvianolate. The Seattle Angina Questionnaire score was also significantly improved in the experimental group than in the control group (P<0.05). No significant differences were observed between the two groups with respect to the incidence of MACEs. Salvianolate was well tolerated. Conclusions Salvianolate appear to have efficacy and well tolerated for elderly patients with UAP. [ClinicalTrials.gov identifier: NCT03037047]
资助项目	Science and Technology Commission of Shanghai MunicipalityScience & Technology Commission of Shanghai Municipality (STCSM) [15DZ1900300]
出版者	SPRINGER
出版地	NEW YORK
ISSN	1672-0415
EISSN	1993-0402
卷号	25 期号:10 页码:728-735
DOI	10.1007/s11655-019-2710-x
页数	8
WOS类目	Integrative & Complementary Medicine
WOS研究方向	Integrative & Complementary Medicine
WOS记录号	WOS:000499678400002
收录类别	SCIE ; PUBMED ; CSCD ; SCOPUS
学科领域	医药、卫生 ; 内科学
URL	查看原文
CSCD记录号	CSCD:6573721
PubMed ID	31782009
SCOPUSEID	2-s2.0-85075600155
通讯作者地址	[Li, Xiao-ying]Department of Geriatric Cardiology,the General Hospital of the People’s Liberation Army,Beijing,100853,China
Scopus学科分类	Complementary and Alternative Medicine;Pharmacology (medical)
引用统计	被引频次：2[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/20671
专题	附属第一医院_干部保健科
通讯作者	Li, Xiao-ying
作者单位	1.Department of Geriatric Cardiology,the General Hospital of the People’s Liberation Army,Beijing,100853,China; 2.Department of Geriatric Clinic,Inner Mongolia People’s Hospital,Hohhot,010017,China; 3.Department of Cardiology,the Second Affiliated Hospital of Nanjing Medical University,Nanjing,210011,China; 4.Second Department of Cadre’s Ward,the First Affiliated Hospital of Harbin Medical University,Harbin,150001,China; 5.Department of Cadre Health Care,Tianjin First Central Hospital,Tianjin,300192,China; 6.Department of Cardiovascular Medicine,Chongqing General Hospital,Chongqing,400013,China; 7.Department of Geriatrics,Shenyang Red Cross Hospital,Shenyang,110063,China; 8.Department of Geriatric Cardiology,Guangzhou First People’s Hospital,Guangzhou,510180,China; 9.Department of Cardiology,Beijing Geriatric Hospital,Beijing,100095,China; 10.the Second Department of Cardiology,the Second Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine,Harbin,150009,China; 11.Department of Cardiology,Guizhou Province Hospital of Traditional Chinese Medicine,Guiyang,550001,China; 12.Department of Cadre’s Ward,the First Bethune Hospital of Jilin University,Changchun,130021,China; 13.Department of Cadre Health Care,the First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China; 14.Medical Department,Shanghai Green Valley Pharmaceutical Co.,Ltd.,Shanghai,201203,China; 15.China Health Promotion Foundation,Beijing,100161,China
推荐引用方式 GB/T 7714	Cui, Hua,Li, Xiao-ying,Gao, Xue-wen,et al. A Prospective Randomized Multicenter Controlled Trial on Salvianolate for Treatment of Unstable Angina Pectoris in A Chinese Elderly Population[J]. CHINESE JOURNAL OF INTEGRATIVE MEDICINE,2019,25(10):728-735.
APA	Cui, Hua., Li, Xiao-ying., Gao, Xue-wen., Lu, Xiang., Wu, Xiu-ping., ... & Zhang, Wen-ju. (2019). A Prospective Randomized Multicenter Controlled Trial on Salvianolate for Treatment of Unstable Angina Pectoris in A Chinese Elderly Population. CHINESE JOURNAL OF INTEGRATIVE MEDICINE, 25(10), 728-735.
MLA	Cui, Hua,et al."A Prospective Randomized Multicenter Controlled Trial on Salvianolate for Treatment of Unstable Angina Pectoris in A Chinese Elderly Population".CHINESE JOURNAL OF INTEGRATIVE MEDICINE 25.10(2019):728-735.

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