血清乳酸脱氢酶对百草枯中毒患者预后的预测价值

doi:10.3760/cma.j.cn121094-20220311-00124

科研成果详情

题名	血清乳酸脱氢酶对百草枯中毒患者预后的预测价值
其他题名	Predictive value of serum lactate dehydrogenase on prognosis of patients with paraquat poisoning
作者	唐亚慧1,3; 陈开源1,3; 胡郁宸1,3; 李孟轩1,3; 殷然1,3; 卢中秋1,3
发表日期	2023-07-20
发表期刊	中华劳动卫生职业病杂志影响因子和分区
语种	中文
原始文献类型	Periodical
关键词	百草枯中毒乳酸脱氢酶预后
其他关键词	Paraquat ; Poisoning ; Lactate dehydrogenase, LDH ; Prognosis
摘要	目的:探讨血清乳酸脱氢酶（LDH）在百草枯（PQ）中毒患者预后中的预测价值，为早期预后评估提供依据。方法:于2022年2月，以2012年1月至2021年12月温州医科大学附属第一医院急诊科收治的PQ中毒且完成血清LDH检测的患者（50例）为观察组，并随机选择健康体检人员（50例）为对照组。根据预后将PQ中毒患者分为存活组与死亡组，比较两组患者入院首次血常规/肝肾功能等指标的差异，建立多因素logisitic回归模型，绘制ROC曲线，分析PQ中毒患者预后的影响因素。结果:与对照组比较，观察组患者入院时白细胞计数（WBC）、总胆红素（TBil）、谷丙转氨酶（ALT）、谷草转氨酶（AST）、LDH、葡萄糖（GLU）、肌酐（Cr）明显升高，白蛋白（ALB）、总胆固醇（TC）明显降低（ P<0.05）。单因素分析显示，PQ中毒存活组与死亡组WBC、LDH升高（以247 U/L为升高）、TBil、ALT、AST、Cr差异均有统计学意义（ P<0.05）。多因素logisitic回归分析显示，血清LDH升高是预测PQ中毒患者预后的独立危险因素（ OR=9.95，95% CI：1.34~73.82， P=0.025）。LDH的ROC曲线下面积为0.811（95% CI：0.692~0.930），截断值为340 U/L时，灵敏度为0.889，特异度为0.719。Log-rank检验结果显示，LDH正常组与升高组的生存率差异有统计学意义（ P=0.001）。结论:血清LDH对评估PQ中毒患者预后有一定的预测价值，LDH升高是PQ中毒患者预后不良的危险因素。
其他摘要	Objective:To investigate the predictive value of serum lactate dehydrogenase (LDH) in the prognosis of patients with paraquat (PQ) poisoning, and to provide evidence for early prognosis assessment.Methods:In February 2022, 50 patients with PQ poisoning who completed serum LDH detection admitted to the Department of Emergency Medicine, the First Affiliated Hospital of Wenzhou Medical University from January 2012 to December 2021 were selected as the observation group, and 50 healthy physical examination personnel were randomly selected as the control group. Patients with PQ poisoning were divided into survival group and death group according to the prognosis, and the differences of blood routine routine, liver and kidney function and other indicators in the first admission between the two groups were compared. Multivariate logisitic regression model was established, ROC curve was drawn, and the influencing factors of prognosis of patients with PQ poisoning were analyzed.Results:Compared with the control group, the white blood cell count (WBC), total bilirubin (TBil), alanine aminotransferase (ALT), aspartate aminotransferase (AST), LDH, glucose (GLU) and creatinine (Cr) in observation group were significantly increased, while albumin (ALB) and total cholesterol (TC) were significantly decreased ( P<0.05). Univariate analysis showed that WBC, elevated LDH (247 U/L), TBil, ALT, AST and Cr were significantly different between PQ poisoning survival group and death group ( P<0.05). Multivariate logisitic regression analysis showed that elevated serum LDH was an independent risk factor for the prognosis of PQ poisoning patients ( OR=9.95, 95% CI: 1.34-73.82, P=0.025). The area under the ROC curve of LDH was 0.811 (95% CI: 0.692-0.930). When the cut-off value was 340 U/L, the sensitivity was 0.889 and the specificity was 0.719. Log-rank test showed that there was a statistically significant difference in survival rate between the normal LDH group and the elevated LDH group ( P=0.001) . Conclusion:Serum LDH has a good predictive value in evaluating the prognosis of patients with PQ poisoning. Elevated LDH is a risk factor for poor prognosis of patients with PQ poisoning.
资助项目	浙江省中医药管理局共建科技计划项目(GZY-ZJ-KJ-23031);温州市重大科技创新项目(ZY2022023)。
ISSN	1001-9391
卷号	41 期号:7 页码:528-533
DOI	10.3760/cma.j.cn121094-20220311-00124
页数	6
收录类别	万方 ; SCOPUS ; 维普 ; CSCD ; ISTIC ; 北大核心
URL	查看原文
PubMed ID	37524677
SCOPUSEID	2-s2.0-85172482690
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/206552
专题	附属第一医院_急诊科温州医科大学
作者单位	1.温州医科大学附属第一医院急诊科，温州　325000; 2.温州市急危重病与救援医学重点实验室，温州　325000; 3.温州医科大学附属第一医院手外科，温州　325000
第一作者单位	附属第一医院_急诊科; 温州医科大学
第一作者的第一单位	附属第一医院_急诊科
推荐引用方式 GB/T 7714	唐亚慧,陈开源,胡郁宸,等. 血清乳酸脱氢酶对百草枯中毒患者预后的预测价值[J]. 中华劳动卫生职业病杂志,2023,41(7):528-533.
APA	唐亚慧, 陈开源, 胡郁宸, 李孟轩, 殷然, & 卢中秋. (2023). 血清乳酸脱氢酶对百草枯中毒患者预后的预测价值. 中华劳动卫生职业病杂志, 41(7), 528-533.
MLA	唐亚慧,et al."血清乳酸脱氢酶对百草枯中毒患者预后的预测价值".中华劳动卫生职业病杂志 41.7(2023):528-533.