克立硼罗软膏和他克莫司软膏对特应性皮炎患儿的疗效观察

doi:10.19829/j.zgfybj.issn.1001-4411.2024.01.013

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题名	克立硼罗软膏和他克莫司软膏对特应性皮炎患儿的疗效观察
其他题名	Observation of therapeutic effects of Clenborough ointment and Tacrolimus ointment on children with atopic dermatitis
作者	徐棉1; 张梦思1; 谢谦 2; 王金蒙 1; 徐贤挺 1; 李智铭3
发表日期	2023-12-26
发表期刊	中国妇幼保健影响因子和分区
语种	中文
原始文献类型	学术期刊
关键词	克立硼罗他克莫司特应性皮炎不良反应皮肤疾病
其他关键词	Crisaborole ; Tacrolimus ; Atopic dermatitis ; Adverse reactions ; Skin diseases
摘要	目的探讨克立硼罗软膏和他克莫司软膏对特应性皮炎(AD)患儿的临床疗效。方法将2022年6月—2023年5月在温州市中心医院治疗的126例AD患儿按照随机分配的原则分为对照组(63例)和观察组(63例)。两组患儿入院后均采取常规处理，对照组给予他克莫司软膏治疗，观察组给予克立硼罗软膏治疗。比较两组临床疗效、AD病情严重程度、AD积分指数(SCORAD)评分以及不良反应。结果观察组治疗总有效率(65.1%vs. 44.4%)高于对照组(P<0.05)。治疗2周后，观察组患儿AD严重程度明显低于对照组(P<0.05)。治疗1周后、治疗2周后，两组患儿SCORAD评分均明显降低，且观察组患儿SCORAD评分低于对照组(P<0.05)。两组患儿不良反应总发生率(7.9%vs. 11.1%)比较差异无统计学意义(P>0.05)。结论与他克莫司软膏相比，采用克立硼罗软膏治疗特应性皮炎患儿的效果更佳，更利于缓解患儿AD症状，且安全性良好。
其他摘要	Objective To explore the clinical efficacy of Crisaborole ointment and Tacrolimus ointment in the treatment of children with atopic dermatitis(AD).Methods 126 children with AD who were treated in Wenzhou Central Hospital from June 2022 to May 2023 were randomly divided into a control group(63 cases)and an observation group(63 cases).Both groups were treated with routine treatment after admission,and the control group was treated with Tacrolimus ointment,the observation group was treated with Crisaborole ointment.The clinical efficacy,severity of AD,SCORAD score and adverse reactions between the two groups were compared.Results The total effective rate of the observation group(65.1％vs.44.4％)was higher than that of the control group(P＜0.05).After 2 weeks of treatment,the se-verity of AD in the observation group was significantly lower than that in the control group(P＜0.05).After 1 week and 2 weeks of treat-ment,the SCORAD scores of both groups of children were significantly reduced,and the SCORAD scores of the observation group were lower than those of the control group(P＜0.05).There was no statistically significant difference in the total incidence of adverse reactions between the two groups of children(7.9％vs.11.1％),comparing differences with statistical significance(P＞0.05).Conclusion Compared with Tacrolimus ointment,Crisaborole ointment is more effective in the treatment of children with atopic dermatitis,more conducive to alleviating the symptoms of children with AD,and has good safety.
资助项目	浙江省温州市科技计划项目(Y20220371);
ISSN	1001-4411
卷号	39 期号:01 页码:48-51
DOI	10.19829/j.zgfybj.issn.1001-4411.2024.01.013
页数	4
收录类别	CNKI ; 万方 ; 维普
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引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/206108
专题	附属第一医院附属第一医院_皮肤科其他_定理临床学院（温州市中心医院）
通讯作者	李智铭
作者单位	1.温州医科大学定理临床学院温州市中心医院; 2.温州市中西医结合医院急诊科; 3.温州医科大学附属第一医院皮肤科
第一作者单位	温州医科大学
第一作者的第一单位	温州医科大学
推荐引用方式 GB/T 7714	徐棉,张梦思,谢谦,等. 克立硼罗软膏和他克莫司软膏对特应性皮炎患儿的疗效观察[J]. 中国妇幼保健,2023,39(01):48-51.
APA	徐棉, 张梦思, 谢谦, 王金蒙, 徐贤挺, & 李智铭. (2023). 克立硼罗软膏和他克莫司软膏对特应性皮炎患儿的疗效观察. 中国妇幼保健, 39(01), 48-51.
MLA	徐棉,et al."克立硼罗软膏和他克莫司软膏对特应性皮炎患儿的疗效观察".中国妇幼保健 39.01(2023):48-51.