Cobalt-doped layered hydroxide coating on titanium implants promotes vascularization and osteogenesis for accelerated fracture healing

doi:10.1016/j.mtbio.2023.100912

科研成果详情

题名	Cobalt-doped layered hydroxide coating on titanium implants promotes vascularization and osteogenesis for accelerated fracture healing
作者	Chen, Xiaodong 1; He, Shuohan 1; Dong, Yilong2; Chen, Maohua 1; Xia, Zengzilu 1; Cai, Kaiyong 1; Hu, Yan 1
发表日期	2024-02
发表期刊	Materials Today Bio 影响因子和分区
语种	英语
原始文献类型	Journal article (JA) ; Journal Article ; Article ; Early Access
关键词	Aluminum coatings Aluminum compounds Bone Cell engineering Cobalt compounds Fracture Stem cells Surface reactions Angiogenesis Bone defect Bone defect repair Defect repair Layered hydroxide coating Layered hydroxides Osseointegration Ti implant Titanium implants Vascularization Ti implants
其他关键词	TI-ALLOYS ; ANGIOGENESIS ; SCAFFOLDS ; COMPLEXATION ; ADHESION
摘要	Angiogenesis at the fracture site plays crucial roles in the endogenous osteogenesis process and is a prerequisite for the efficient repair of implant fixed bone defects. To improve the peri-implant vascularization of titanium implant for accelerating defect healing, we developed a Co-doped Mg–Al layered hydroxide coating on the surface of titanium using hydrothermal reaction and then modified the surface with gallic acid (Ti-LDH/GA). Gallic acid coating enabled the sustained release of Co2+ and Mg2+ to the defect site over a month. Ti-LDH/GA treatment profoundly stimulated the angiogenic potential of endothelial cells by upregulating the vascularization regulators such as vascular endothelial growth factor VEGF) and hypoxia-inducible factor-1α (HIF-1α), leading to enhanced osteogenic capability of mesenchymal stem cells (MSCs). These pro-bone healing benefits were attributed to the synergistic effects of Co ions and Mg ions in promoting angiogenesis and new bone formation. These insights collectively suggested the potent pro-osteogenic effect of Ti-LDH/GA through leveraging peri-implant vascularization, offering a new approach for developing biofunctional titanium implants. © 2023 The Author(s)
资助项目	National Key R&D Program of China [2022YFB3804400]; National Natural Science Foundation of China [51773023, 21734002, 51825302]; Natural Science Foundation of Chongqing China [CSTB2022NSCQ-MSX0488]
出版者	Elsevier B.V.
ISSN	2590-0064
EISSN	2590-0064
卷号	24
DOI	10.1016/j.mtbio.2023.100912
页数	13
WOS类目	Engineering, Biomedical ; Materials Science, Biomaterials
WOS研究方向	Engineering ; Materials Science
WOS记录号	WOS:001147887500001
收录类别	EI ; PUBMED ; SCIE ; SCOPUS
在线发表日期	2023-12
EI入藏号	20235215286449
EI主题词	Cell culture
EI分类号	461.1 Biomedical Engineering ; 461.2 Biological Materials and Tissue Engineering ; 802.2 Chemical Reactions ; 813.2 Coating Materials ; 951 Materials Science
URL	查看原文
PubMed ID	3822601
SCOPUSEID	2-s2.0-85180613897
通讯作者地址	[Hu, Yan]College of Bioengineering,Chongqing University,Chongqing,400044,China ; [Cai, Kaiyong]College of Bioengineering,Chongqing University,Chongqing,400044,China ; [Xia, Zengzilu]College of Bioengineering,Chongqing University,Chongqing,400044,China
Scopus学科分类	Biotechnology;Bioengineering;Biomaterials;Biomedical Engineering;Molecular Biology;Cell Biology
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/205731
专题	其他_附属第三医院（瑞安市人民医院）
通讯作者	Xia, Zengzilu; Cai, Kaiyong; Hu, Yan
作者单位	1.College of Bioengineering,Chongqing University,Chongqing,400044,China; 2.Department of Orthopaedics,The Third Affiliated Hospital of Wenzhou Medical University (Ruian People's Hospital),Wenzhou,325016,China
推荐引用方式 GB/T 7714	Chen, Xiaodong,He, Shuohan,Dong, Yilong,et al. Cobalt-doped layered hydroxide coating on titanium implants promotes vascularization and osteogenesis for accelerated fracture healing[J]. Materials Today Bio,2024,24.
APA	Chen, Xiaodong., He, Shuohan., Dong, Yilong., Chen, Maohua., Xia, Zengzilu., ... & Hu, Yan. (2024). Cobalt-doped layered hydroxide coating on titanium implants promotes vascularization and osteogenesis for accelerated fracture healing. Materials Today Bio, 24.
MLA	Chen, Xiaodong,et al."Cobalt-doped layered hydroxide coating on titanium implants promotes vascularization and osteogenesis for accelerated fracture healing".Materials Today Bio 24(2024).