Denticleless E3 ubiquitin protein ligase (DTL) maintains the proliferation and differentiation of epidermis and hair follicles during skin development

doi:10.1002/dvdy.682

科研成果详情

题名	Denticleless E3 ubiquitin protein ligase (DTL) maintains the proliferation and differentiation of epidermis and hair follicles during skin development
作者	Lin, Yanhui 1; Tang, Weibo2,3; Huang, Peijun2; Wang, Zhendong4; Duan, Lian5; Jia, Chonghui 6; Sun, Ruizhen 7; Liu, Li 1; Shen, Jingling 1,7
发表日期	2023-12-22
发表期刊	DEVELOPMENTAL DYNAMICS 影响因子和分区
语种	英语
原始文献类型	Article ; Early Access
关键词	DTL epidermal development p53
其他关键词	GENOME STABILITY ; CELL-CYCLE ; S PHASE ; P53 ; P63 ; CRL4(CDT2) ; PCNA ; UBIQUITYLATION ; 14-3-3-SIGMA ; DEGRADATION
摘要	BackgroundA precise balance between the proliferation and differentiation of epidermal progenitors is required to achieve the barrier function during the development of epidermis. During the entire process of skin development, the newly formed basal layer cells divide, differentiate, and migrate outward to the surface of the skin, which is tightly regulated by a series of events related to cell cycle progression. The CRL4DTL complex (Cullin 4 RING ligase, in association with the substrate receptor DTL) has long emerged as a master regulator in various cellular processes, which mediates the degradation of key cell cycle proteins. However, the roles of DTL in regulating epidermal morphogenesis during skin development remain unclear.ResultsWe showed that DTL deficiency in epidermal progenitor cells leads to defects in epidermal stratification and loss of hair follicles accompanied by reduced epidermal progenitor cells and disturbed cell cycle progression during skin development. Transcriptome analysis revealed that p53 pathway is activated in DTL-depleted epidermal progenitor cells. The apoptosis of epidermal cells showed in DTL deficiency mice is rescued by the absence of p53, but the proliferation and differentiation defects were p53-independent.ConclusionOur findings indicate that DTL plays a vital role in epidermal malformation during skin development.
资助项目	National Natural Science Foundation of China
出版者	WILEY
ISSN	1058-8388
EISSN	1097-0177
卷号	253 期号:7 页码:635-647
DOI	10.1002/dvdy.682
页数	13
WOS类目	Anatomy & Morphology ; Developmental Biology
WOS研究方向	Anatomy & Morphology ; Developmental Biology
WOS记录号	WOS:001129492500001
收录类别	SCIE ; PUBMED ; SCOPUS
在线发表日期	2023-12
URL	查看原文
PubMed ID	38131461
SCOPUSEID	2-s2.0-85180246495
通讯作者地址	[Liu, Li]Institute of Life Sciences,College of Life and Environmental Science,Wenzhou University,Wenzhou,325035,China
Scopus学科分类	Developmental Biology
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/205378
专题	药学院（分析测试中心）附属第一医院第一临床医学院（信息与工程学院）、附属第一医院_中心实验室
通讯作者	Liu, Li
作者单位	1.Institute of Life Sciences,College of Life and Environmental Science,Wenzhou University,Wenzhou,China; 2.School of Pharmaceutical Sciences,Wenzhou Medical University,Wenzhou,China; 3.Laboratory of Tumor Targeted Therapy and Translational Medicine,Jilin Medical University,Jilin,China; 4.Key Laboratory of Interventional Pulmonology of Zhejiang Province,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China; 5.Central Laboratory,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China; 6.Department of Endodontics,The First Affiliated Hospital of Harbin Medical University,Harbin,China; 7.Department of Histology and Embryology,Harbin Medical University,Harbin,China
推荐引用方式 GB/T 7714	Lin, Yanhui,Tang, Weibo,Huang, Peijun,et al. Denticleless E3 ubiquitin protein ligase (DTL) maintains the proliferation and differentiation of epidermis and hair follicles during skin development[J]. DEVELOPMENTAL DYNAMICS,2023,253(7):635-647.
APA	Lin, Yanhui., Tang, Weibo., Huang, Peijun., Wang, Zhendong., Duan, Lian., ... & Shen, Jingling. (2023). Denticleless E3 ubiquitin protein ligase (DTL) maintains the proliferation and differentiation of epidermis and hair follicles during skin development. DEVELOPMENTAL DYNAMICS, 253(7), 635-647.
MLA	Lin, Yanhui,et al."Denticleless E3 ubiquitin protein ligase (DTL) maintains the proliferation and differentiation of epidermis and hair follicles during skin development".DEVELOPMENTAL DYNAMICS 253.7(2023):635-647.