FGF Signaling Pathway: A Key Regulator of Stem Cell Pluripotency

doi:10.3389/fcell.2020.00079

科研成果详情

题名	FGF Signaling Pathway: A Key Regulator of Stem Cell Pluripotency
作者	Mossahebi-Mohammadi, Majid 1; Quan, Meiyu1; Zhang, Jin-San1,2; Li, Xiaokun1
发表日期	2020-02-18
发表期刊	FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY 影响因子和分区
语种	英语
原始文献类型	Review
关键词	FGF stem cells pluripotency self-renewal transcription factor
其他关键词	MOUSE EMBRYONIC FIBROBLASTS ; SELF-RENEWAL ; GROUND-STATE ; GROWTH-FACTORS ; DIFFERENTIATION ; EXPRESSION ; NAIVE ; DERIVATION ; LINES ; FIBROBLAST-GROWTH-FACTOR-4
摘要	Pluripotent stem cells (PSCs) isolated in vitro from embryonic stem cells (ESCs), induced PSC (iPSC) and also post-implantation epiblast-derived stem cells (EpiSCs) are known for their two unique characteristics: the ability to give rise to all somatic lineages and the self-renewal capacity. Numerous intrinsic signaling pathways contribute to the maintenance of the pluripotency state of stem cells by tightly controlling key transcriptional regulators of stemness including sex determining region Y box 2 (Sox-2), octamer-binding transcription factor (Oct)3/4, krueppel-like factor 4 (Klf-4), Nanog, and c-Myc. Signaling by fibroblast growth factor (FGF) is of critical importance in regulating stem cells pluripotency. The FGF family is comprised of 22 ligands that interact with four FGF receptors (FGFRs). FGF/FGFR signaling governs fundamental cellular processes such as cell survival, proliferation, migration, differentiation, embryonic development, organogenesis, tissue repair/regeneration, and metabolism. FGF signaling is mediated by the activation of RAS - mitogen-activated protein kinase (MAPK), phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K)-AKT, Phospholipase C Gamma (PLC gamma), and signal transducers and activators of transcription (STAT), which intersects and synergizes with other signaling pathways such as Wnt, retinoic acid (RA) and transforming growth factor (TGF)-beta signaling. In the current review, we summarize the role of FGF signaling in the maintenance of pluripotency state of stem cells through regulation of key transcriptional factors.
资助项目	China Postdoctoral Fellowship; Wenzhou Medical University; National Key R&D Program of China [2017YFA0506000]
出版者	FRONTIERS MEDIA SA
出版地	LAUSANNE
ISSN	2296-634X
卷号	8 页码:79
DOI	10.3389/fcell.2020.00079
页数	10
WOS类目	Cell Biology ; Developmental Biology
WOS研究方向	Cell Biology ; Developmental Biology
WOS记录号	WOS:000518698500001
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	32133359
PMC记录号	PMC7040165
SCOPUSEID	2-s2.0-85080887145
通讯作者地址	[Zhang, Jin-San]School of Pharmaceutical Sciences and International Collaborative Center on Growth Factor Research,Wenzhou Medical University,Wenzhou,China
Scopus学科分类	Developmental Biology;Cell Biology
引用统计	被引频次：79[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/2048
专题	药学院（分析测试中心）卓越中心_国际生长因子研究院
通讯作者	Zhang, Jin-San
作者单位	1.School of Pharmaceutical Sciences and International Collaborative Center on Growth Factor Research,Wenzhou Medical University,Wenzhou,China; 2.Institute of Life Sciences,Wenzhou University,Wenzhou,China
第一作者单位	药学院（分析测试中心）
通讯作者单位	药学院（分析测试中心）
第一作者的第一单位	药学院（分析测试中心）
推荐引用方式 GB/T 7714	Mossahebi-Mohammadi, Majid,Quan, Meiyu,Zhang, Jin-San,et al. FGF Signaling Pathway: A Key Regulator of Stem Cell Pluripotency[J]. FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY,2020,8:79.
APA	Mossahebi-Mohammadi, Majid, Quan, Meiyu, Zhang, Jin-San, & Li, Xiaokun. (2020). FGF Signaling Pathway: A Key Regulator of Stem Cell Pluripotency. FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 8, 79.
MLA	Mossahebi-Mohammadi, Majid,et al."FGF Signaling Pathway: A Key Regulator of Stem Cell Pluripotency".FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY 8(2020):79.