The effect of trans-resveratrol on post-stroke depression via regulation of hypothalamus-pituitary-adrenal axis

doi:10.1016/j.neuropharm.2015.04.017

科研成果详情

题名	The effect of trans-resveratrol on post-stroke depression via regulation of hypothalamus-pituitary-adrenal axis
作者	Pang, Cong 1; Cao, Liang 1; Wu, Fan 2; Wang, Li 3; Wang, Gang 4; Yu, Yingcong5; Zhang, Meixi 6; Chen, Lichao 6; Wang, Weijie 1; Lv, Weihong 7; Chen, Ling 4; Zhu, Jiejin 4; Pan, Jianchun2; Zhang, Hanting 8; Xu, Ying 2,9; Ding, Lianshu 1
发表日期	2015-10
发表期刊	NEUROPHARMACOLOGY 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Trans-resveratrol Post-stroke depression (PSD) Middle cerebral artery occlusion (MCAO) Hypothalamus-pituitary-adrenal axis BDNF
其他关键词	CEREBRAL-ARTERY OCCLUSION ; HPA AXIS ; ISCHEMIA-REPERFUSION ; ADRENOCORTICAL AXIS ; CURCUMIN REVERSES ; MAJOR DEPRESSION ; OXIDATIVE STRESS ; MOUSE MODEL ; RATS ; MICE
摘要	Post-stroke depression (PSD) occurs about 40% among all stroke survivors, but the effective pharmacotherapy is inadequately understood. The present study investigated the effects of a natural polyphenol trans-resveratrol (RES) on behavioral changes after middle cerebral artery occlusion (MCAO) and examined what its molecular targets may be. RES was shown to decrease the infarct size and neurological scores after MCAO, suggesting the amelioration of brain damage and motor activity. RES also reversed the depressive-like behaviors 13 days after MCAO, both in the forced swimming and sucrose consumption tests. Moreover, MCAO-induced series abnormalities related to depressive-like behaviors, such as an abnormal adrenal gland weight to body weight ratio, an increased expression of the corticotropin-releasing factor (CRF) in the frontal cortex, hippocampus and hypothalamus, the differential expression of glucocorticoid receptor (GR) in these three brain regions, and a decreased brain-derived neurotrophic factor (BDNF) level, were ameliorated after treatment with increasing doses of RES at 10, 20 and 40 mg/kg via gavage. These findings provide compelling evidence that RES protects the brain against focal cerebral ischemia-induced injury, but most of all is its antidepressant-like effect on PSD, which might at least in part be mediated by regulation of hypothalamus-pituitary-adrenal axis function. (C) 2015 Elsevier Ltd. All rights reserved.
资助项目	Medicine and Health Science and Technology Plan Projects in Zhejiang Province [2012KYA151]; National Natural Science Foundation for Young Investigators [NSFY 81400600]; Zhejiang province association of chinese integrative medicine [2012LY011]; Zhejiang Province Extremely Key Subject Building Funding Pharmacology and Biochemical Pharmaceutics; Latitudinal project of Wenzhou Medical University [95012011]; Natural Science Foundation of Zhejiang ProvinceNatural Science Foundation of Zhejiang Province [Y14H310034]
出版者	PERGAMON-ELSEVIER SCIENCE LTD
出版地	OXFORD
ISSN	0028-3908
EISSN	1873-7064
卷号	97 页码:447-456
DOI	10.1016/j.neuropharm.2015.04.017
页数	10
WOS类目	Neurosciences ; Pharmacology & Pharmacy
WOS研究方向	Neurosciences & Neurology ; Pharmacology & Pharmacy
WOS记录号	WOS:000360869700046
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	25937213
SCOPUSEID	2-s2.0-84931282585
通讯作者地址	[Xu, Ying]Brain Institute, School of Pharmacy, Wenzhou Medical University,Wenzhou,325021,China
Scopus学科分类	Pharmacology;Cellular and Molecular Neuroscience
引用统计	被引频次：52[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/20083
专题	药学院（分析测试中心）药学院（分析测试中心）_实验神经生物研究所
通讯作者	Xu, Ying
作者单位	1.Department of Neurosurgery, Huai'An First People's Hospital, Nanjing Medical University,Huai'an,223300,China; 2.Brain Institute, School of Pharmacy, Wenzhou Medical University,Wenzhou,325021,China; 3.Clinical Laboratory, Xuzhou No.1 People's Hospital,Xuzhou,221002,China; 4.Department of Pharmacy, Hangzhou First People's Hospital, Hangzhou,Zhejiang Province,310006,China; 5.Wenzhou Third People's Hospital, Wenzhou Medical University,Wenzhou,325000,China; 6.Pingyang Hospital of Traditional Chinese Medicine,Pingyang,325400,China; 7.WenLing Hospital of Traditional Chinese Medicine,Wenling,317500,China; 8.Department of Behavioral Medicine and Psychiatry, West Virginia University,Morgantown,26505,United States; 9.Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, State University of New York at Buffalo,Buffalo,14214,United States
通讯作者单位	实验神经生物研究所
推荐引用方式 GB/T 7714	Pang, Cong,Cao, Liang,Wu, Fan,et al. The effect of trans-resveratrol on post-stroke depression via regulation of hypothalamus-pituitary-adrenal axis[J]. NEUROPHARMACOLOGY,2015,97:447-456.
APA	Pang, Cong., Cao, Liang., Wu, Fan., Wang, Li., Wang, Gang., ... & Ding, Lianshu. (2015). The effect of trans-resveratrol on post-stroke depression via regulation of hypothalamus-pituitary-adrenal axis. NEUROPHARMACOLOGY, 97, 447-456.
MLA	Pang, Cong,et al."The effect of trans-resveratrol on post-stroke depression via regulation of hypothalamus-pituitary-adrenal axis".NEUROPHARMACOLOGY 97(2015):447-456.