Clinical Application and Long-Term Follow-Up Study of Porcine Acellular Dermal Matrix Combined With Autoskin Grafting

doi:10.1097/BCR.0b013e3181d0f42d

科研成果详情

题名	Clinical Application and Long-Term Follow-Up Study of Porcine Acellular Dermal Matrix Combined With Autoskin Grafting
作者	Jiong, Chen 1; Jiake, Chai 2; Chunmao, Han 3; Yingen, Pan 4; Qiuhe, Wu 5; Zhouxi, Fang 6; Xiangsheng, Feng 7
发表日期	2010-03
发表期刊	JOURNAL OF BURN CARE & RESEARCH 影响因子和分区
语种	英语
原始文献类型	Article
摘要	The purpose of this study was to investigate the clinical effects of porcine acellular dermal matrix combined with autoskin grafting on full-thickness skin defects using long-term clinical follow-up study and histologic examination. One hundred fifty-two patients with deep burn or trauma hospitalized from February 2000 to July 2003 were repaired with porcine acellular dermal matrix and split-thickness autoskin graft. Take rate of the grafts was calculated on 1 week after operation. Scar hyperplasia was examined on 1, 3, 6, and 12 months after operation. At the same time, the contracture rates of grafted areas were also calculated. Skin biopsy was performed on five patients for histologic examination, as well as transmission electron microscopy 78 months after operation. The take rate of grafts of 116 patients (76.3%) was 100%, and the take rate of the rest of the patients ( 36 patients, 23.7%) was more than 95%. No one needed skin transplantation for the second time. One hundred twenty-seven patients were followed up on 1 month after operation; grafts showed mild contraction. There was slight cicatricle at skin junction with tender texture. There was no obvious pruritus and blister. One hundred one patients were followed up on 3 months after operation. The graft contraction showed obvious relief with good articular function. Eighty-two patients were followed up on 6 months after operation. The color and texture of the grafts were similar to normal skin without obvious cicatricial hyperplasia. Fifty-eight patients were followed up on 12 months after operation. The grafts were similar to normal skin without obvious rejection. There were no significant differences between the contracture rates at 3, 6, and 12 months and 1 month after the second surgery. Sixteen patients were followed up on 78 months after operation. The appearance of grafts was slightly dry compared with normal skin. Tissue structure of grafts was similar to normal skin with sweat gland-like structure, and sweat gland cells were shown in the dermis. Xenogenic acellular dermal matrix combined with split-thickness autograft can repair full-thickness skin defects and inhibit scar proliferation without obvious immune rejection for long time. Newly formed sweat gland-like structure and sweat gland cells in the dermis may be a new research point for reconstruction of skin function. (J Burn Care Res 2010;31:280-285)
出版者	OXFORD UNIV PRESS
出版地	OXFORD
ISSN	1559-047X
EISSN	1559-0488
卷号	31 期号:2 页码:280-285
DOI	10.1097/BCR.0b013e3181d0f42d
页数	6
WOS类目	Critical Care Medicine ; Dermatology ; Surgery
WOS研究方向	General & Internal Medicine ; Dermatology ; Surgery
WOS记录号	WOS:000275193400008
收录类别	SCIE ; SCOPUS
URL	查看原文
PubMed ID	20182383
SCOPUSEID	2-s2.0-77649333752
通讯作者地址	[Qiuhe, Wu]Department of Burns and Plastic Surgery,Jinan Central Hospital,Shandong University,China
Scopus学科分类	Surgery;Emergency Medicine;Rehabilitation
引用统计	被引频次：18[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/19820
专题	温州医科大学检验医学院（生命科学学院、生物学实验教学中心）_生物学实验教学中心_显微镜室、电镜室
通讯作者	Qiuhe, Wu
作者单位	1.Department of Burns,Hospital of Wenzhou Medical Collage,China; 2.Department of Burns and Plastic Surgery,General Hospital of People's Liberation Army,China; 3.Department of Burns,Hospital of Zhejiang University,China; 4.Department of Burns and Plastic Surgery,People's Hospital of Qidong,China; 5.Department of Burns and Plastic Surgery,Jinan Central Hospital,Shandong University,China; 6.Department of Electron Microscopy,Wenzhou Medical College,China; 7.Department of Burns and Plastic Surgery,First People's Hospital of Foshan,Zhongshan University,China
第一作者单位	温州医科大学
第一作者的第一单位	温州医科大学
推荐引用方式 GB/T 7714	Jiong, Chen,Jiake, Chai,Chunmao, Han,et al. Clinical Application and Long-Term Follow-Up Study of Porcine Acellular Dermal Matrix Combined With Autoskin Grafting[J]. JOURNAL OF BURN CARE & RESEARCH,2010,31(2):280-285.
APA	Jiong, Chen., Jiake, Chai., Chunmao, Han., Yingen, Pan., Qiuhe, Wu., ... & Xiangsheng, Feng. (2010). Clinical Application and Long-Term Follow-Up Study of Porcine Acellular Dermal Matrix Combined With Autoskin Grafting. JOURNAL OF BURN CARE & RESEARCH, 31(2), 280-285.
MLA	Jiong, Chen,et al."Clinical Application and Long-Term Follow-Up Study of Porcine Acellular Dermal Matrix Combined With Autoskin Grafting".JOURNAL OF BURN CARE & RESEARCH 31.2(2010):280-285.