NF-rBp50、p53、Bcl-2在宫颈癌组织中的表达及其与人乳头瘤病毒感染的关系

科研成果详情

题名	NF-rBp50、p53、Bcl-2在宫颈癌组织中的表达及其与人乳头瘤病毒感染的关系
其他题名	Expressions of NF-κBp50, p53 and Bcl-2 in cervical cancer and their relationship with human papillomavirus infection*
作者	张婵1; 陈向敏1; 夏克栋2; Haiyan Dong2
发表日期	2006
发表期刊	中德临床肿瘤学杂志（英文版）影响因子和分区
语种	英语
原始文献类型	Periodical
其他关键词	cervical cancer ; NF-κBp50 ; p53 ; Bcl-2 ; HPV
摘要	Objective: To explore the relationship between expressions of NF-κBp50, p53 and Bcl-2 in tissue of cervical cancer and human papillomavirus (HPV) infection. Methods: The expressions of NF-κBp50, p53 and Bcl-2 were detected using immuohistochemical staining in 46 specimens of cervical cancer and 26 specimens of normal cervical tissue. The infection of HPV DNA were determined by PCR. Results: The expressions of NF-κBp50, p53 and Bcl-2 in tissue of cervical cancer were significantly higher than that in normal cervical tissue (P＜0.01), and the expressions of NF-κBp50 and p53 or Bcl-2 were closely related (P＜0.05). The expression of NF-κBp50 in HPV DNA positive group was significantly higher than that in HPV negative group (P＜0.05), but there were no significantly differences in the expressions of p53 and Bcl-2 between HPV DNA positive group and HPV negative group (P＞0.05). Conclusion: The expressions of NF-κBp50, p53 and Bcl-2 were significantly correlated with cervical carcinogenesis. NF-κBp50 may be activated by HPV infection.
资助项目	S2001A30:浙江省温州市科技局项目
ISSN	1610-1979
卷号	5 期号:6 页码:451-453
页数	3
收录类别	万方 ; ISTIC
URL	查看原文
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/197338
专题	基础医学院（机能实验教学中心）_病原生物学与免疫学系
作者单位	1.The Biological Laboratory Education Center, Wenzhou Medical College, Wenzhou 325027, China; 2.Department of Microbiology and Immunology, Wenzhou Medical College, Wenzhou 325027, China
第一作者单位	温州医科大学
第一作者的第一单位	温州医科大学
推荐引用方式 GB/T 7714	张婵,陈向敏,夏克栋,等. NF-rBp50、p53、Bcl-2在宫颈癌组织中的表达及其与人乳头瘤病毒感染的关系[J]. 中德临床肿瘤学杂志（英文版）,2006,5(6):451-453.
APA	张婵, 陈向敏, 夏克栋, & Haiyan Dong. (2006). NF-rBp50、p53、Bcl-2在宫颈癌组织中的表达及其与人乳头瘤病毒感染的关系. 中德临床肿瘤学杂志（英文版）, 5(6), 451-453.
MLA	张婵,et al."NF-rBp50、p53、Bcl-2在宫颈癌组织中的表达及其与人乳头瘤病毒感染的关系".中德临床肿瘤学杂志（英文版） 5.6(2006):451-453.