Prospects of Directly Reprogrammed Adult Human Neurons for Neurodegenerative Disease Modeling and Drug Discovery: iN vs. iPSCs Models

doi:10.3389/fnins.2020.546484

科研成果详情

题名	Prospects of Directly Reprogrammed Adult Human Neurons for Neurodegenerative Disease Modeling and Drug Discovery: iN vs. iPSCs Models
作者	Zhang, Ying 1,2; Xie, Xinyang 1,2,3; Hu, Jiangnan 4; Afreen, Kazi Sabrina 5; Zhang, Chun-Li 6; Zhuge, Qichuan1,2; Yang, Jianjing1,2
发表日期	2020-11-19
发表期刊	FRONTIERS IN NEUROSCIENCE 影响因子和分区
语种	英语
原始文献类型	Review
关键词	iN iPSCs disease modeling drug screening neurodegenerative disease
其他关键词	PLURIPOTENT STEM-CELLS ; FAMILIAL ALZHEIMERS-DISEASE ; AMYOTROPHIC-LATERAL-SCLEROSIS ; HUMAN FIBROBLASTS ; DIRECT CONVERSION ; DOPAMINERGIC-NEURONS ; MOTOR-NEURONS ; GABAERGIC INTERNEURONS ; FUNCTIONAL-NEURONS ; GENETIC CORRECTION
摘要	A reliable disease model is critical to the study of specific disease mechanisms as well as for the discovery and development of new drugs. Despite providing crucial insights into the mechanisms of neurodegenerative diseases, translation of this information to develop therapeutics in clinical trials have been unsuccessful. Reprogramming technology to convert adult somatic cells to induced Pluripotent Stem Cells (iPSCs) or directly reprogramming adult somatic cells to induced Neurons (iN), has allowed for the creation of better models to understand the molecular mechanisms and design of new drugs. In recent times, iPSC technology has been commonly used for modeling neurodegenerative diseases and drug discovery. However, several technological challenges have limited the application of iN. As evidence suggests, iN for the modeling of neurodegenerative disorders is advantageous compared to those derived from iPSCs. In this review, we will compare iPSCs and iN models for neurodegenerative diseases and their potential applications in the future.
资助项目	National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81771262]; Zhejiang Health Science and Technology Project [2016RCA022]; Zhejiang Key Research and Development Project [2017C03027]; Zhejiang Provincial Natural Science Foundation of ChinaNatural Science Foundation of Zhejiang Province [LQ20H090005]
出版者	FRONTIERS MEDIA SA
出版地	LAUSANNE
ISSN	1662-4548
EISSN	1662-453X
卷号	14 页码:546484
DOI	10.3389/fnins.2020.546484
页数	11
WOS类目	Neurosciences
WOS研究方向	Neurosciences & Neurology
WOS记录号	WOS:000595116000001
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
Pubmed记录号	33328842
PMC记录号	PMC7710799
Scopus记录号	2-s2.0-85097248583
通讯作者地址	[Zhuge, Qichuan]Zhejiang Provincial Key Laboratory of Aging and Neurological Disorder Research,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China ; [Yang, Jianjing]Zhejiang Provincial Key Laboratory of Aging and Neurological Disorder Research,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China ; [Zhuge, Qichuan]Department of Neurosurgery,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China ; [Yang, Jianjing]Department of Neurosurgery,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China
scopus学科分类	Neuroscience (all)
引用统计	被引频次：3[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/19523
专题	第一临床医学院（信息与工程学院）、附属第一医院_老化与神经疾病重点实验室附属第一医院_神经外科
通讯作者	Zhuge, Qichuan; Yang, Jianjing
作者单位	1.Zhejiang Provincial Key Laboratory of Aging and Neurological Disorder Research,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China; 2.Department of Neurosurgery,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China; 3.International Department of The Affiliated High School of South,China Normal University (HFI),Guangzhou,China; 4.Department of Pharmaceutical Sciences,University of North Texas Health Science Center,Fort Worth,TX,United States; 5.Department of Microbiology Immunology,Rosalind Franklin University of Medicine and Science,North Chicago,IL,United States; 6.Department of Molecular Biology,UT Southwestern Medical Center,Dallas,United States
第一作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院
通讯作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Zhang, Ying,Xie, Xinyang,Hu, Jiangnan,et al. Prospects of Directly Reprogrammed Adult Human Neurons for Neurodegenerative Disease Modeling and Drug Discovery: iN vs. iPSCs Models[J]. FRONTIERS IN NEUROSCIENCE,2020,14:546484.
APA	Zhang, Ying., Xie, Xinyang., Hu, Jiangnan., Afreen, Kazi Sabrina., Zhang, Chun-Li., ... & Yang, Jianjing. (2020). Prospects of Directly Reprogrammed Adult Human Neurons for Neurodegenerative Disease Modeling and Drug Discovery: iN vs. iPSCs Models. FRONTIERS IN NEUROSCIENCE, 14, 546484.
MLA	Zhang, Ying,et al."Prospects of Directly Reprogrammed Adult Human Neurons for Neurodegenerative Disease Modeling and Drug Discovery: iN vs. iPSCs Models".FRONTIERS IN NEUROSCIENCE 14(2020):546484.