Metabolic fate of glucose in the brain of APP/PS1 transgenic mice at 10 months of age: a C-13 NMR metabolomic study

doi:10.1007/s11011-018-0274-7

科研成果详情

题名	Metabolic fate of glucose in the brain of APP/PS1 transgenic mice at 10 months of age: a C-13 NMR metabolomic study
作者	Zhou, Qi; Zheng, Hong; Chen, Jiuxia; Li, Chen; Du, Yao; Xia, Huanhuan; Gao, Hongchang
发表日期	2018-10
发表期刊	METABOLIC BRAIN DISEASE 影响因子和分区
语种	英语
原始文献类型	Article
关键词	C-13 flux Energy metabolism Brain glucose Neurodegenerative disease Neurotransmitter
其他关键词	NUCLEAR-MAGNETIC-RESONANCE ; ALZHEIMERS-DISEASE ; RAT-BRAIN ; ASTROCYTES ; NEURONS ; ALANINE
摘要	Alzheimer's disease (AD) has been associated with the disturbance of brain glucose metabolism. The present study investigates brain glucose metabolism using C-13 NMR metabolomics in combination with intravenous [1-C-13]-glucose infusion in APP/PS1 transgenic mouse model of amyloid pathology at 10 months of age. We found that brain glucose was significantly accumulated in APP/PS1 mice relative to wild-type (WT) mice. Reductions in C-13 fluxes into the specific carbon sites of tricarboxylic acid (TCA) intermediate (succinate) as well as neurotransmitters (glutamate, glutamine, gamma-aminobutyric acid and aspartate) from [1-C-13]-glucose were also detected in the brain of APP/PS1 mice. In addition, our results reveal that the C-13-enrichments of the C3 of alanine were significantly lower and the C3 of lactate have a tendency to be lower in the brain of APP/PS1 mice than WT mice. Taken together, the development of amyloid pathology could cause a reduction in glucose utilization and further result in decreases in energy and neurotransmitter metabolism as well as the lactate-alanine shuttle in the brain.
资助项目	National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21605115, 21575105]; Public Welfare Technology Application Research Foundation of Zhejiang Province [2017C33066]
出版者	SPRINGER/PLENUM PUBLISHERS
出版地	NEW YORK
ISSN	0885-7490
EISSN	1573-7365
卷号	33 期号:5 页码:1661-1668
DOI	10.1007/s11011-018-0274-7
页数	8
WOS类目	Endocrinology & Metabolism ; Neurosciences
WOS研究方向	Endocrinology & Metabolism ; Neurosciences & Neurology
WOS记录号	WOS:000445154200029
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	29946959
SCOPUSEID	2-s2.0-85049116387
通讯作者地址	[Zheng, Hong]Institute of Metabonomics & Medical NMR,School of Pharmaceutical Science,Wenzhou Medical University,Wenzhou,325035,China
Scopus学科分类	Biochemistry;Neurology (clinical);Cellular and Molecular Neuroscience
引用统计	被引频次：10[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/19484
专题	附属第二医院_核磁共振室
通讯作者	Zheng, Hong
作者单位	Institute of Metabonomics & Medical NMR,School of Pharmaceutical Science,Wenzhou Medical University,Wenzhou,325035,China
第一作者单位	温州医科大学
通讯作者单位	温州医科大学
第一作者的第一单位	温州医科大学
推荐引用方式 GB/T 7714	Zhou, Qi,Zheng, Hong,Chen, Jiuxia,et al. Metabolic fate of glucose in the brain of APP/PS1 transgenic mice at 10 months of age: a C-13 NMR metabolomic study[J]. METABOLIC BRAIN DISEASE,2018,33(5):1661-1668.
APA	Zhou, Qi., Zheng, Hong., Chen, Jiuxia., Li, Chen., Du, Yao., ... & Gao, Hongchang. (2018). Metabolic fate of glucose in the brain of APP/PS1 transgenic mice at 10 months of age: a C-13 NMR metabolomic study. METABOLIC BRAIN DISEASE, 33(5), 1661-1668.
MLA	Zhou, Qi,et al."Metabolic fate of glucose in the brain of APP/PS1 transgenic mice at 10 months of age: a C-13 NMR metabolomic study".METABOLIC BRAIN DISEASE 33.5(2018):1661-1668.