Sex Differences in Abnormal Intrinsic Functional Connectivity After Acute Mild Traumatic Brain Injury

doi:10.3389/fncir.2018.00107

科研成果详情

题名	Sex Differences in Abnormal Intrinsic Functional Connectivity After Acute Mild Traumatic Brain Injury
作者	Wang, Shan 1; Hu, Liuxun 2; Cao, Jieli 1; Huang, Wenmin 1; Sun, Chuanzhu 1; Zheng, Dongdong2; Wang, Zhuonan 3; Gan, Shuoqiu 1,3; Niu, Xuan 3; Gu, Chenghui 2; Bai, Guanghui4; Ye, Limei 4; Zhang, Danbin 4; Zhang, Nu2; Yin, Bo2; Zhang, Ming 3; Bai, Lijun 1
发表日期	2018-11-29
发表期刊	FRONTIERS IN NEURAL CIRCUITS 影响因子和分区
语种	英语
原始文献类型	Article
关键词	mild traumatic brain injury sex difference rs-fMRI functional connectivity independent component analysis
其他关键词	RESTING-STATE NETWORKS ; COLLABORATING CENTER ; CONCUSSION SYMPTOMS ; SLEEP-DEPRIVATION ; VISUAL FUNCTION ; WORKING-MEMORY ; TASK-FORCE ; FMRI ; PERFORMANCE ; COMPONENTS
摘要	Mild traumatic brain injury (TBI) is considered to induce abnormal intrinsic functional connectivity within resting-state networks (RSNs). The objective of this study was to estimate the role of sex in intrinsic functional connectivity after acute mild TBI. We recruited a cohort of 54 patients (27 males and 27 females with mild TBI within 7 days post-injury) from the emergency department (ED) and 34 age-, education-matched healthy controls (HCs; 17 males and 17 females). On the clinical scales, there were no statistically significant differences between males and females in either control group or mild TBI group. To detect whether there was abnormal sex difference on functional connectivity in RSNs, we performed independent component analysis (ICA) and a dual regression approach to investigate the between-subject voxel-wise comparisons of functional connectivity within seven selected RSNs. Compared to female patients, male patients showed increased intrinsic functional connectivity in motor network, ventral stream network, executive function network, cerebellum network and decreased connectivity in visual network. Further analysis demonstrated a positive correlation between the functional connectivity in executive function network and insomnia severity index (ISI) scores in male patients (r = 0.515, P = 0.006). The abnormality of the functional connectivity of RSNs in acute mild TBI showed the possibility of brain recombination after trauma, mainly concerning male-specific.
资助项目	National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81571752, 81771914]; National key research and development plan of China [2016YFC0100300]; Zhejiang Natural Science FoundationNatural Science Foundation of Zhejiang Province [LY15H090016]; Wenzhou Municipal Sci-Tech Bureau [Y20140577]; Fundamental Research Funds for the Central UniversitiesFundamental Research Funds for the Central Universities [Xjj 2018229]
出版者	FRONTIERS MEDIA SA
出版地	LAUSANNE
ISSN	1662-5110
卷号	12 页码:107
DOI	10.3389/fncir.2018.00107
页数	10
WOS类目	Neurosciences
WOS研究方向	Neurosciences & Neurology
WOS记录号	WOS:000461824800001
收录类别	SCIE ; SSCI ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	30555304
PMC记录号	PMC6282647
SCOPUSEID	2-s2.0-85058749057
通讯作者地址	[Bai, Lijun]The Key Laboratory of Biomedical Information Engineering,Ministry of Education,Department of Biomedical Engineering,School of Life Science and Technology,Xi’an Jiaotong University,Xi’an,China
Scopus学科分类	Neuroscience (miscellaneous);Sensory Systems;Cognitive Neuroscience;Cellular and Molecular Neuroscience
引用统计	被引频次：6[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/1945
专题	第二临床医学院，附属第二医院、育英儿童医院
通讯作者	Bai, Lijun
作者单位	1.The Key Laboratory of Biomedical Information Engineering,Ministry of Education,Department of Biomedical Engineering,School of Life Science and Technology,Xi’an Jiaotong University,Xi’an,China; 2.Department of Neurosurgery,The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University,Wenzhou,China; 3.Department of Medical Imaging,The First Affiliated Hospital of Xi’an Jiaotong University,Xi’an,China; 4.Department of Radiology,The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University,Wenzhou,China
推荐引用方式 GB/T 7714	Wang, Shan,Hu, Liuxun,Cao, Jieli,et al. Sex Differences in Abnormal Intrinsic Functional Connectivity After Acute Mild Traumatic Brain Injury[J]. FRONTIERS IN NEURAL CIRCUITS,2018,12:107.
APA	Wang, Shan., Hu, Liuxun., Cao, Jieli., Huang, Wenmin., Sun, Chuanzhu., ... & Bai, Lijun. (2018). Sex Differences in Abnormal Intrinsic Functional Connectivity After Acute Mild Traumatic Brain Injury. FRONTIERS IN NEURAL CIRCUITS, 12, 107.
MLA	Wang, Shan,et al."Sex Differences in Abnormal Intrinsic Functional Connectivity After Acute Mild Traumatic Brain Injury".FRONTIERS IN NEURAL CIRCUITS 12(2018):107.