Effects of Polybrominated Diphenyl Ethers on Rat and Human 11 beta-Hydroxysteroid Dehydrogenase 1 and 2 Activities

doi:10.1159/000445213

科研成果详情

题名	Effects of Polybrominated Diphenyl Ethers on Rat and Human 11 beta-Hydroxysteroid Dehydrogenase 1 and 2 Activities
作者	Chen, Xiaomin1; Dong, Yaoyao1; Cao, Shuyan1; Li, Xiaoheng 1; Wang, Zhe2; Chen, Ruijie2; Ge, Ren-Shan1
发表日期	2016-12-31
发表期刊	PHARMACOLOGY 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Steroids Polybrominated diphenyl ether 11 beta-Hydroxysteroid dehydrogenase 1 11 beta-Hydroxysteroid dehydrogenase 2 Glucocorticoid metabolism
其他关键词	BETA-HYDROXYSTEROID DEHYDROGENASE ; APPARENT MINERALOCORTICOID EXCESS ; GLUCOCORTICOID-RECEPTOR ; LEYDIG-CELLS ; TYPE-2 ; KIDNEY ; ENZYME ; LOCALIZATION ; HYPERTENSION ; REGULATOR
摘要	Polybrominated diphenyl ethers (PBDEs) are a class of brominated flame retardants. PBDEs have been widely used in textiles, flexible polyurethane foams, electronic components, electrical components, and plastics. 11 beta-Hydroxysteroid dehydrogenases, isoform 1 (HSD11B1) and isoform 2 (HSD11B2), have been demonstrated to be the regulators of local glucocorticoid levels. In this study, the potencies of 4 different PBDEs (BDE-3, BDE-47, BDE-100, and BDE-153) with 1-6 bromine atoms attached in inhibition of rat and human HSD11B1 and HSD11B2 activities were compared to 4-bromobiphenyl (BBP), a structurally similar compound. All 4 PBDEs and BBP did not inhibit rat and human HSD11B1. BDE-3 and BDE-47 potently inhibited rat HSD11B2, and BDE- 47 and BDE- 153 potently inhibited human HSD11B2, with the half maximal inhibitory concentration values of 12.42, 5.95, 11.97, and 4.41 mu mol/l, respectively. All PBDEs noncompetitively inhibited HSD11B2 when a steroid substrate was used. However, PBDEs exerted uncompetitive inhibition when the cofactor NAD(+) was used. In conclusion, some PBDEs are selective inhibitors of HSD11B2, possibly causing excessive glucocorticoid action in local tissues. (C) 2016 S. Karger AG, Basel
资助项目	Health Bureau of Zhejiang Province [11-CX29, 2013ZDA017]
出版者	KARGER
出版地	BASEL
ISSN	0031-7012
EISSN	1423-0313
卷号	98 期号:3-4 页码:115-123
DOI	10.1159/000445213
页数	9
WOS类目	Pharmacology & Pharmacy
WOS研究方向	Pharmacology & Pharmacy
WOS记录号	WOS:000380138800003
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	27198750
SCOPUSEID	2-s2.0-84969903608
通讯作者地址	[Ge, Ren-Shan]Wenzhou Med Univ, Affiliated Hosp 2, Ctr Sci Res, Wenzhou 325027, Peoples R China. ; [Chen, Ruijie]Wenzhou Med Univ, Affiliated Hosp 2, Dept Pharm, Wenzhou 325027, Peoples R China.
Scopus学科分类	Pharmacology
引用统计	被引频次：1[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/19379
专题	附属第二医院_科研中心附属第二医院
通讯作者	Chen, Ruijie; Ge, Ren-Shan
作者单位	1.Wenzhou Med Univ, Affiliated Hosp 2, Ctr Sci Res, Wenzhou 325027, Peoples R China; 2.Wenzhou Med Univ, Affiliated Hosp 2, Dept Pharm, Wenzhou 325027, Peoples R China
第一作者单位	附属第二医院_科研中心
通讯作者单位	附属第二医院_科研中心; 附属第二医院
第一作者的第一单位	附属第二医院_科研中心
推荐引用方式 GB/T 7714	Chen, Xiaomin,Dong, Yaoyao,Cao, Shuyan,et al. Effects of Polybrominated Diphenyl Ethers on Rat and Human 11 beta-Hydroxysteroid Dehydrogenase 1 and 2 Activities[J]. PHARMACOLOGY,2016,98(3-4):115-123.
APA	Chen, Xiaomin., Dong, Yaoyao., Cao, Shuyan., Li, Xiaoheng., Wang, Zhe., ... & Ge, Ren-Shan. (2016). Effects of Polybrominated Diphenyl Ethers on Rat and Human 11 beta-Hydroxysteroid Dehydrogenase 1 and 2 Activities. PHARMACOLOGY, 98(3-4), 115-123.
MLA	Chen, Xiaomin,et al."Effects of Polybrominated Diphenyl Ethers on Rat and Human 11 beta-Hydroxysteroid Dehydrogenase 1 and 2 Activities".PHARMACOLOGY 98.3-4(2016):115-123.