Normal Absolute Monocyte Count at the Time of Relapse is Associated with Improved Survival After First Salvage Therapy in Adult Patients with Early Relapsed B-Lineage Acute Lymphoblastic Leukemia

doi:10.2147/CMAR.S264194

科研成果详情

题名	Normal Absolute Monocyte Count at the Time of Relapse is Associated with Improved Survival After First Salvage Therapy in Adult Patients with Early Relapsed B-Lineage Acute Lymphoblastic Leukemia
作者	Shi, Yi-Fen1; Wang, Na 2; Huang, Zi-Yang1; Chen, Rong-Rong 1; Huang, Yi-Sha 1; Zhu, Yi-Yi1; Xing, Chong-Yun1; Liang, Bin1; Yu, Kang1; Feng, Jian-Hua1,3
发表日期	2020
发表期刊	CANCER MANAGEMENT AND RESEARCH 影响因子和分区
语种	英语
原始文献类型	Article
关键词	B-lineage acute lymphoblastic leukemia early relapse absolute monocyte count prognosis survival
其他关键词	BLOOD LYMPHOCYTE/MONOCYTE RATIO ; DIAGNOSIS ; RECOVERY ; CYTOGENETICS ; OUTCOMES ; IMPACT
摘要	Background: Peripheral monocytes, a key cell type for innate immunity, have been shown to be associated with survival in various types of hematological malignancies. However, no previous studies regarding the prognostic impact of peripheral absolute monocyte count (AMC) in early relapsed B-lineage acute lymphoblastic leukemia (B-ALL) have been reported. Methods: Forty-nine cases of early relapsed adult B-ALL were reviewed. The upper (0.80 x 10(9)/L) and lower limits (0.12 x 10(9)/L) of the normal value for AMC were used as cut-off points. Kaplan-Meier curves and Log rank test were used for comparison of overall survival (OS). The univariate and multivariate Cox proportional hazards models were used for investigating the factors associated with OS. Results: More than half (59.2%) of all patients showed a normal AMC (0.12-0.80 x 10(9)/L). The median follow-up was 5.3 months from the start of first salvage therapy. Univariate analysis revealed that normal AMC (versus low/high AMC) at the time of relapse was a prognostic factor for improved OS (P = 0.021). On multivariate analysis, normal AMC (versus low/high AMC) at the time of relapse remained an independent prognostic factor for improved OS (hazard ratio = 0.43, P = 0.030). Conclusion: AMC at the time of relapse, which can be easily derived from routine clinical laboratory testing of complete blood count, might be used as a prognostic marker for survival outcomes in adult patients with early relapsed B-ALL.
资助项目	Natural Science Foundation of Zhejiang ProvinceNatural Science Foundation of Zhejiang Province [LQ19H080002]; Public Welfare Science and Technology Project of Wenzhou [Y20160099, Y20190119]
出版者	DOVE MEDICAL PRESS LTD
出版地	ALBANY
ISSN	1179-1322
卷号	12 页码:7097-7105
DOI	10.2147/CMAR.S264194
页数	9
WOS类目	Oncology
WOS研究方向	Oncology
WOS记录号	WOS:000582441700001
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	32848464
PMC记录号	PMC7428316
SCOPUSEID	2-s2.0-85089799767
通讯作者地址	[Yu, Kang]Department of Hematology,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China ; [Feng, Jian-Hua]Department of Hematology,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China ; [Feng, Jian-Hua]Department of Pediatric Hematology-Oncology,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China
Scopus学科分类	Oncology
引用统计	被引频次[WOS]：0 [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/19140
专题	附属第一医院_血液内科第一临床医学院（信息与工程学院）、附属第一医院_医疗保健中心
通讯作者	Yu, Kang; Feng, Jian-Hua
作者单位	1.Department of Hematology,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China; 2.Health Care Center,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China; 3.Department of Pediatric Hematology-Oncology,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China
第一作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院
通讯作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Shi, Yi-Fen,Wang, Na,Huang, Zi-Yang,et al. Normal Absolute Monocyte Count at the Time of Relapse is Associated with Improved Survival After First Salvage Therapy in Adult Patients with Early Relapsed B-Lineage Acute Lymphoblastic Leukemia[J]. CANCER MANAGEMENT AND RESEARCH,2020,12:7097-7105.
APA	Shi, Yi-Fen., Wang, Na., Huang, Zi-Yang., Chen, Rong-Rong., Huang, Yi-Sha., ... & Feng, Jian-Hua. (2020). Normal Absolute Monocyte Count at the Time of Relapse is Associated with Improved Survival After First Salvage Therapy in Adult Patients with Early Relapsed B-Lineage Acute Lymphoblastic Leukemia. CANCER MANAGEMENT AND RESEARCH, 12, 7097-7105.
MLA	Shi, Yi-Fen,et al."Normal Absolute Monocyte Count at the Time of Relapse is Associated with Improved Survival After First Salvage Therapy in Adult Patients with Early Relapsed B-Lineage Acute Lymphoblastic Leukemia".CANCER MANAGEMENT AND RESEARCH 12(2020):7097-7105.