High Neutrophil-to-Platelet Ratio Is Associated With Hemorrhagic Transformation in Patients With Acute Ischemic Stroke

doi:10.3389/fneur.2019.01310

科研成果详情

题名	High Neutrophil-to-Platelet Ratio Is Associated With Hemorrhagic Transformation in Patients With Acute Ischemic Stroke
作者	He, Weilei 1; Ruan, Yiting 1; Yuan, Chengxiang 1; Cheng, Qianqian 2; Cheng, Haoran 1; Zeng, Yaying 2; Chen, Yunbin 1; Huang, Guiqian1; Chen, Huijun 1; He, Jincai1
发表日期	2019-12-10
发表期刊	FRONTIERS IN NEUROLOGY 影响因子和分区
语种	英语
原始文献类型	Article
关键词	neutrophil-to-platelet ratio stroke hemorrhagic transformation parenchymal hematoma outcome
其他关键词	INTRAVENOUS ALTEPLASE ; INFARCTION ; PREDICTORS ; THERAPY ; DAMAGE ; COUNT ; THROMBOLYSIS ; INFLAMMATION ; EXPRESSION ; MORTALITY
摘要	Background: Hemorrhagic transformation (HT) is a complication that may cause neurological deterioration in patients with acute ischemic stroke. Both neutrophil and platelet have been associated with the stroke progression. The aim of this study was to explore the relationship between neutrophil-to-platelet ratio (NPR) and HT after acute ischemic stroke. Methods: A total of 279 stroke patients with HT were consecutively recruited. HT was diagnosed using magnetic resonance imaging (MRI) or computed tomography (CT) and classified into hemorrhagic infarction (HI) and parenchymal hematoma (PH). Blood samples for neutrophil and platelet counts were obtained at admission. Meanwhile, 270 age- and gender-matched controls without HT were included for comparison. Results: Among the patients with HT, 131 patients had PH and 148 patients had HI. NPR was higher in patients with PH than those with HI or non-HT [36.8 (23.7-49.2) vs. 26.6 (17.9-38.3) vs. 19.1 (14.8-24.8), P < 0.001]. After adjustment for potential confounders, high NPR remained independently associated with the increased risk of HT (OR = 2.000, 95% CI: 1.041-3.843, P = 0.037). NPR (>39.9) was independently associated with PH (OR = 2.641, 95% CI: 1.308-5.342, P = 0.007). Conclusions: High NPR was associated with the increased risk of HT especially PH in patients with acute ischemic stroke.
资助项目	National Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81873799]; National Key Technology Research and Development Program of the Ministry of Science and Technology of ChinaNational Key Technology R&D Program [2015BAI13B01]; Wenzhou Municipal Sci-Tech Bureau Program [Y20160002]
出版者	FRONTIERS MEDIA SA
出版地	LAUSANNE
ISSN	1664-2295
卷号	10 页码:1310
DOI	10.3389/fneur.2019.01310
页数	8
WOS类目	Clinical Neurology ; Neurosciences
WOS研究方向	Neurosciences & Neurology
WOS记录号	WOS:000505251500001
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	31920933
PMC记录号	PMC6914868
SCOPUSEID	2-s2.0-85077301943
通讯作者地址	[He, Jincai]Department of Neurology,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China
Scopus学科分类	Neurology;Neurology (clinical)
引用统计	被引频次：15[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/18840
专题	第一临床医学院（信息与工程学院）、附属第一医院_内科学_神经内科附属第一医院第一临床医学院（信息与工程学院）、附属第一医院_精神病与精神卫生学_精神卫生科
通讯作者	He, Jincai
作者单位	1.Department of Neurology,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China; 2.Department of Mental Health,Mental Health School,Wenzhou Medical University,Wenzhou,China
第一作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院
通讯作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	He, Weilei,Ruan, Yiting,Yuan, Chengxiang,et al. High Neutrophil-to-Platelet Ratio Is Associated With Hemorrhagic Transformation in Patients With Acute Ischemic Stroke[J]. FRONTIERS IN NEUROLOGY,2019,10:1310.
APA	He, Weilei., Ruan, Yiting., Yuan, Chengxiang., Cheng, Qianqian., Cheng, Haoran., ... & He, Jincai. (2019). High Neutrophil-to-Platelet Ratio Is Associated With Hemorrhagic Transformation in Patients With Acute Ischemic Stroke. FRONTIERS IN NEUROLOGY, 10, 1310.
MLA	He, Weilei,et al."High Neutrophil-to-Platelet Ratio Is Associated With Hemorrhagic Transformation in Patients With Acute Ischemic Stroke".FRONTIERS IN NEUROLOGY 10(2019):1310.