A seven-lncRNA signature for predicting prognosis in breast carcinoma

doi:10.21037/tcr-21-747

科研成果详情

题名	A seven-lncRNA signature for predicting prognosis in breast carcinoma
作者	Xu, Min1; Chen, Ziyan2; Lin, Bangyi 3; Zhang, Sina 4; Qu, Jinmiao3
发表日期	2021-09
发表期刊	TRANSLATIONAL CANCER RESEARCH 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Long non-coding RNAs (IncRNAs) breast carcinoma propnosis biosignature
其他关键词	LONG NONCODING RNAS ; EXPRESSION ANALYSIS ; CANCER STATISTICS ; PATHWAY ; FREQUENCY ; FRONTIER ; RISK
摘要	Background: Long non-coding RNAs (lncRNAs) play an important part in tumorigenesis and cancer metastasis and can serve as a potential biosignature for cancer prognosis. However, the use of lncRNA signatures to predict survival in breast carcinoma is yet unreported. Methods: The lncRNA expression profiles and homologous clinical data of 913 breast carcinoma samples from the Cancer Genome Atlas (TCGA), were analyzed to obtain 2,547 differentially expressed lncRNAs. Univariate Cox proportional risk regression was applied to both the training and testing datasets to screen the common prognostic lncRNAs. Potential prognostic LncRNAs were screened by multivariate Cox proportional risk regression in the training data set of the selected LncRNAs. Results: Seven lncRNAs (LINC02037, MAPT-AS1, RP1-37C10.3, RP11-344E13.4, RP11-454P21.1, RP11-616M22.1, SPACA6P-AS) were prominently associated with overall survival. Kaplan-Meier analysis and receiver operating characteristic (ROC) curves indicated that these indicators were sensitive and specific for survival prediction. The areas under the ROC curve of the seven-lncRNA signature in predicting 3-and 5-year survival rates were 0.771 and 0.780 respectively in the combined cohort. Furthermore, enrichment analysis revealed that these seven lncRNAs might participate multiple pathways related to tumorigenesis and prognosis. Conclusions: The proposed seven-lncRNA signature could serve as a latent prognostic biomarker for survival prediction in patients with breast carcinoma.
资助项目	Natural Science Foundation of Zhejiang ProvinceNatural Science Foundation of Zhejiang Province [LY17H160053]; Wenzhou Science and Technology Bureau [Y20180460]
出版者	AME PUBL CO
出版地	SHATIN
ISSN	2218-676X
EISSN	2219-6803
卷号	10 期号:9 页码:4033-+
DOI	10.21037/tcr-21-747
页数	21
WOS类目	Oncology
WOS研究方向	Oncology
WOS记录号	WOS:000685204400001
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	35116701
PMC记录号	PMC8797290
SCOPUSEID	2-s2.0-85116323584
通讯作者地址	[Qu, Jinmiao]Department of Thyroid and Breast Surgery,The First Affiliated Hospital,Wenzhou Medical University,Wenzhou,China
Scopus学科分类	Oncology;Radiology, Nuclear Medicine and Imaging;Cancer Research
引用统计	被引频次：2[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/18806
专题	附属第一医院_肝胆外科第一临床医学院（信息与工程学院）、附属第一医院_浙江省胰脏肝脏危重性疾病重点实验室
通讯作者	Qu, Jinmiao
作者单位	1.Department of Operating Room,The First Affiliated Hospital,Wenzhou Medical University,Wenzhou,China; 2.Department of Hepatobiliary Surgery,The First Affiliated Hospital,Wenzhou Medical University,Wenzhou,China; 3.Department of Thyroid and Breast Surgery,The First Affiliated Hospital,Wenzhou Medical University,Wenzhou,China; 4.Key Laboratory of Diagnosis and Treatment of Severe Hepato-Pancreatic Diseases of Zhejiang Province,The First Affiliated Hospital,Wenzhou Medical University,Wenzhou,China
第一作者单位	附属第一医院
通讯作者单位	附属第一医院
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Xu, Min,Chen, Ziyan,Lin, Bangyi,et al. A seven-lncRNA signature for predicting prognosis in breast carcinoma[J]. TRANSLATIONAL CANCER RESEARCH,2021,10(9):4033-+.
APA	Xu, Min, Chen, Ziyan, Lin, Bangyi, Zhang, Sina, & Qu, Jinmiao. (2021). A seven-lncRNA signature for predicting prognosis in breast carcinoma. TRANSLATIONAL CANCER RESEARCH, 10(9), 4033-+.
MLA	Xu, Min,et al."A seven-lncRNA signature for predicting prognosis in breast carcinoma".TRANSLATIONAL CANCER RESEARCH 10.9(2021):4033-+.