FGF23(C-tail) improves diabetic nephropathy by attenuating renal fibrosis and inflammation

doi:10.1186/s12896-018-0449-7

科研成果详情

题名	FGF23(C-tail) improves diabetic nephropathy by attenuating renal fibrosis and inflammation
作者	Zhang, Xiaomin; Guo, Kaiwen; Xia, Feng; Zhao, Xinyu; Huang, Zhifeng; Niu, Jianlou
发表日期	2018-05-30
发表期刊	BMC BIOTECHNOLOGY 影响因子和分区
语种	英语
原始文献类型	Article
关键词	FGF23 Diabetic nephropathy Inflammation Fibrosis
其他关键词	GROWTH-FACTOR 23 ; MOLECULAR-MECHANISMS ; FGF23 ; MORTALITY ; DISEASE ; HYPOPHOSPHATEMIA ; EXPRESSION ; BIOMARKERS ; PHOSPHATE ; INSIGHTS
摘要	Background: High level of serum fibroblast growth factor 23 (FGF23) is implicated in the development and progression of diabetic nephropathy (DN), making it a crucial factor in the pathogenesis of DN. FGF23 is also tightly correlated with inflammation in the progression of DN. The aim of this study was to explore whether the C-terminal of FGF23 (FGF23(C-tail)), an antagonist that can block the FGF23 signaling pathway by competing with intact FGF23, could exhibit a therapeutic effect on DN. Results: Biochemical data and histological examination showed that FGF23C-tail administration ameliorated the functional and morphological abnormalities of db/db mice with DN without changing the levels of circulating FGF23 and phosphate. Evaluation of morphology and fibrosis by Masson's trichrome staining and IHC staining of fibronectin, PCR, and western blot analysis showed that FGF23C(-tail) prevents diabetes-induced fibrosis in db/db mice. Importantly, FGF23(C-tail) decreased the levels of inflammatory cytokines in serum and renal tissues. Conclusion: FGF23(C-tail) may improve diabetic nephropathy by decreasing inflammation and fibrosis in db/db mice, suggesting that blocking of FGF23 action remains an important therapeutic target for the prevention or attenuation of the progression of DN.
资助项目	Natural Science Foundation of ZhejiangNatural Science Foundation of Zhejiang Province [LY15H300004]; Natural Science Foundation of Zhejiang ProvinceNatural Science Foundation of Zhejiang Province [LQ15H310005]; Science and Technology Project of Wenzhou [Y20140724, Y20140734, Y20160163, Y20170165]
出版者	BMC
出版地	LONDON
ISSN	1472-6750
EISSN	1472-6750
卷号	18 期号:1 页码:33
DOI	10.1186/s12896-018-0449-7
页数	41
WOS类目	Biotechnology & Applied Microbiology
WOS研究方向	Biotechnology & Applied Microbiology
WOS记录号	WOS:000433586600001
收录类别	SCIE ; PUBMED ; EI ; SCOPUS
EI入藏号	20182205266094
EI主题词	Pathology
URL	查看原文
PubMed ID	29843712
PMC记录号	PMC5975516
SCOPUSEID	2-s2.0-85047665776
通讯作者地址	[Huang, Zhifeng]Department of Biopharmacy,School of Pharmacy,Wenzhou Medical University,Chashan Town, Wenzhou,325035,China
Scopus学科分类	Biotechnology
引用统计	被引频次：25[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/18718
专题	药学院（分析测试中心）_生物制药系
通讯作者	Huang, Zhifeng
作者单位	Wenzhou Medical University,Department of Biopharmacy,School of Pharmacy,Chashan Town, Wenzhou,325035,China
第一作者单位	温州医科大学
通讯作者单位	温州医科大学
第一作者的第一单位	温州医科大学
推荐引用方式 GB/T 7714	Zhang, Xiaomin,Guo, Kaiwen,Xia, Feng,et al. FGF23(C-tail) improves diabetic nephropathy by attenuating renal fibrosis and inflammation[J]. BMC BIOTECHNOLOGY,2018,18(1):33.
APA	Zhang, Xiaomin, Guo, Kaiwen, Xia, Feng, Zhao, Xinyu, Huang, Zhifeng, & Niu, Jianlou. (2018). FGF23(C-tail) improves diabetic nephropathy by attenuating renal fibrosis and inflammation. BMC BIOTECHNOLOGY, 18(1), 33.
MLA	Zhang, Xiaomin,et al."FGF23(C-tail) improves diabetic nephropathy by attenuating renal fibrosis and inflammation".BMC BIOTECHNOLOGY 18.1(2018):33.