Upregulation of CELSR1 expression promotes ovarian cancer cell proliferation, migration, and invasion

doi:10.1007/s12032-023-02232-1

科研成果详情

题名	Upregulation of CELSR1 expression promotes ovarian cancer cell proliferation, migration, and invasion
作者	Zuo, Jiwei 1; Zheng, Anqi 1; Wang, Xingyue1; Luo, Zhicheng1; Chen, Yueming1; Cheng, Xiaoxiao1; Zhao, Yuemei 1; Zhou, Xian 2; Tang, Kai-Fu1,3; Du, Xing 4
发表日期	2023-12-09
发表期刊	Medical oncology (Northwood, London, England) 影响因子和分区
语种	英语
原始文献类型	Journal Article
关键词	CELSR1 Ovarian cancer Proliferation Proteoglycans RNA sequencing
其他关键词	PROGRESSION ; LEUKEMIA ; VCAN
摘要	Cadherin epidermal growth factor and laminin-G seven-pass G-type receptor 1 (CELSR1) is a planar cell polarity protein involved in the transmission of directional cues to align either individual cells within an epithelial sheet or multicellular clusters. CELSR1 has been suggested to play a role in glioma, breast cancer, and chronic lymphocytic leukemia development; however, whether it has a role in the pathogenesis of ovarian cancer remains unknown. The aim of this study was to determine the role of CELSR1 in ovarian cancer and elucidate its underlying molecular mechanisms. By analyzing gene expression data downloaded from the Cancer Genome Atlas database, we found that CELSR1 expression was upregulated in ovarian cancer tissues compared to that in normal ovarian tissues. High CELSR1 expression levels were associated with poor prognosis in patients with ovarian cancer. Cell proliferation, scratch, and transwell assays revealed that CELSR1 promoted the proliferation, migration, and invasion of ovarian cancer cells in vitro. In addition, transcriptome sequencing analysis revealed that CELSR1 knockdown in T29H cells resulted in the dysregulation of the expression of 1320 genes. Further analysis revealed that genes involved in proliferation- and migration-associated signaling pathways were regulated by CELSR1. Our study demonstrates that CELSR1 is highly expressed in ovarian cancer cells and regulates their proliferation and migration, suggesting its potential as a diagnostic marker and therapeutic target.
资助项目	National Natural Science Foundation of China[81972648];National Natural Science Foundation of China[82172915]
出版者	HUMANA PRESS INC
ISSN	1357-0560
EISSN	1559-131X
卷号	41 期号:1
DOI	10.1007/s12032-023-02232-1
页数	12
WOS类目	Oncology
WOS研究方向	Oncology
WOS记录号	WOS:001118300800001
收录类别	PUBMED ; SCIE ; SCOPUS
URL	查看原文
PubMed ID	38070011
SCOPUSEID	2-s2.0-85178934267
通讯作者地址	[Tang, Kai-Fu]Key Laboratory of Diagnosis and Treatment of Severe Hepato-Pancreatic Diseases of Zhejiang Province,The First Affiliated Hospital of Wenzhou Medical University,Zhejiang,Wenzhou,325015,China ; [Du, Xing]Department of Orthopedics,The First Affiliated Hospital of Chongqing Medical University,Chongqing,400016,China
Scopus学科分类	Hematology;Oncology;Cancer Research
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/185938
专题	附属第一医院
通讯作者	Tang, Kai-Fu; Du, Xing
作者单位	1.Key Laboratory of Diagnosis and Treatment of Severe Hepato-Pancreatic Diseases of Zhejiang Province,The First Affiliated Hospital of Wenzhou Medical University,Zhejiang,Wenzhou,325015,China; 2.Department of Radiation Oncology,Chongqing University Cancer Hospital,181, Hanyu Road, Shapingba District,Chongqing,400030,China; 3.Key Laboratory of Molecular Biology On Infectious Diseases,Ministry of Education,Chongqing Medical University,Chongqing,400016,China; 4.Department of Orthopedics,The First Affiliated Hospital of Chongqing Medical University,Chongqing,400016,China
第一作者单位	附属第一医院
通讯作者单位	附属第一医院
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Zuo, Jiwei,Zheng, Anqi,Wang, Xingyue,et al. Upregulation of CELSR1 expression promotes ovarian cancer cell proliferation, migration, and invasion[J]. Medical oncology (Northwood, London, England),2023,41(1).
APA	Zuo, Jiwei., Zheng, Anqi., Wang, Xingyue., Luo, Zhicheng., Chen, Yueming., ... & Du, Xing. (2023). Upregulation of CELSR1 expression promotes ovarian cancer cell proliferation, migration, and invasion. Medical oncology (Northwood, London, England), 41(1).
MLA	Zuo, Jiwei,et al."Upregulation of CELSR1 expression promotes ovarian cancer cell proliferation, migration, and invasion".Medical oncology (Northwood, London, England) 41.1(2023).