Insights into the complex interactions between Rab22a and extracellular vesicles in cancers

doi:10.1007/s00011-023-01821-0

科研成果详情

题名	Insights into the complex interactions between Rab22a and extracellular vesicles in cancers
作者	Huang, Shenghao 1; Bao, Yuxuan 1; Kong, Lingjie1; Gao, Sheng 2; Hua, Chunyan3
发表日期	2023-12-08
发表期刊	Inflammation research : official journal of the European Histamine Research Society ... [et al.] 影响因子和分区
语种	英语
原始文献类型	Journal Article ; Review
关键词	Cancer Extracellular vesicles Rab GTPase Rab22a
其他关键词	CLATHRIN-INDEPENDENT CARGO ; TUMOR MICROENVIRONMENT ; HYPOXIA ; MECHANISMS ; CD147 ; CELLS ; PROLIFERATION ; GLYCOSYLATION ; INVASION ; STAT3
摘要	Oncogenic Ras-related GTP-binding proteins, referred to as Rabs, are characterized by their intricate interactions with upstream, downstream molecules, and notably, extracellular vesicles (EVs). While the expansive family of Rabs and their associated signaling pathways have been exhaustively dissected, Rab22a emerges as an entity of outstanding interest, owing to its potent influence in many biological processes and its conspicuous correlation with cancer metastasis and migration. A burgeoning interest in the interactions between Rab22a and EVs in the field of oncology underscores the necessity for more in-depth reviews and scholarly discourses., We performed a review based on published original and review articles related to Rab22a, tumor, microRNA, exosome, microvesicles, EVs, CD147, lysosome, degradation, endosomal recycling, etc. from PubMed, Web of Science and Google Scholar databases., We summarize the regulatory processes governing the expression of Rab22a and the mutants of Rab22a. Notably, the present understanding of complex interactions between Rab22a and EVs are highlighted, encompassing both the impact of Rab22a on the genesis of EVs and the role of EVs that are affected by Rab22a mutants in propelling tumor advancement. The dynamic interaction between Rab22a and EVs plays a significant role in the progression of tumors, and it can provide novel insights into the pathogenesis of cancers and the development of new therapeutic targets.
资助项目	Science and Technology Plan Project of Wenzhou, China[Y20220045];Science and Technology Plan Project of Wenzhou, China[Y20220389];National Natural Science Foundation of China[81901660];Natural Science Foundation of Zhejiang Province[LTGY23H100001]
出版者	SPRINGER BASEL AG
ISSN	1023-3830
EISSN	1420-908X
卷号	73 期号:1 页码:99-110
DOI	10.1007/s00011-023-01821-0
页数	12
WOS类目	Cell Biology ; Immunology
WOS研究方向	Cell Biology ; Immunology
WOS记录号	WOS:001116790500001
收录类别	PUBMED ; SCIE ; SCOPUS
URL	查看原文
PubMed ID	38066108
SCOPUSEID	2-s2.0-85178964934
通讯作者地址	[Gao, Sheng]Laboratory Animal Center,Wenzhou Medical University,Zhejiang,Wenzhou,325035,China ; [Hua, Chunyan]School of Basic Medical Sciences,Wenzhou Medical University,Zhejiang,Wenzhou,325035,China
Scopus学科分类	Immunology;Pharmacology
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/185929
专题	温州医科大学基础医学院（机能实验教学中心）实验动物中心
通讯作者	Gao, Sheng; Hua, Chunyan
作者单位	1.School of the 2nd Clinical Medical Sciences,Wenzhou Medical University,Wenzhou,China; 2.Laboratory Animal Center,Wenzhou Medical University,Zhejiang,Wenzhou,325035,China; 3.School of Basic Medical Sciences,Wenzhou Medical University,Zhejiang,Wenzhou,325035,China
第一作者单位	温州医科大学
通讯作者单位	实验动物中心; 基础医学院（机能实验教学中心）
第一作者的第一单位	温州医科大学
推荐引用方式 GB/T 7714	Huang, Shenghao,Bao, Yuxuan,Kong, Lingjie,et al. Insights into the complex interactions between Rab22a and extracellular vesicles in cancers[J]. Inflammation research : official journal of the European Histamine Research Society ... [et al.],2023,73(1):99-110.
APA	Huang, Shenghao, Bao, Yuxuan, Kong, Lingjie, Gao, Sheng, & Hua, Chunyan. (2023). Insights into the complex interactions between Rab22a and extracellular vesicles in cancers. Inflammation research : official journal of the European Histamine Research Society ... [et al.], 73(1), 99-110.
MLA	Huang, Shenghao,et al."Insights into the complex interactions between Rab22a and extracellular vesicles in cancers".Inflammation research : official journal of the European Histamine Research Society ... [et al.] 73.1(2023):99-110.