Influence of renal sympathetic denervation on the cardiac function of dogs with heart failure

科研成果详情

题名	Influence of renal sympathetic denervation on the cardiac function of dogs with heart failure
作者	Huang, Damin 1; Li, Yong 2; Hou, Shuxin 1; Zhang, Jinchun 1; Song, Lei 1; Lu, Yingmin 1
发表日期	2016-02-29
发表期刊	International Journal of Clinical and Experimental Medicine; 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Dog Heart failure Renal sympathetic denervation Right ventricular pacing Sympathetic nervous system
摘要	Objective: This study aimed to investigate the influence of renal sympathetic denervation (RSDN) on the cardiac function of dogs with heart failure. Methods: A total of 40 dogs were randomly assigned into RSDN group and control group (n=20 per group). In RSDN group, dogs received radiofrequency ablation of bilateral renal arteries; dogs in control group received femoral artery puncture alone. Pacemaker (VOO module) was implanted in 40 dogs, and rapid right ventricular pacing was introduced to establish heart failure model. The maximum left ventricular end systolic diameter (LVESD), maximum left ventricular end-diastolic diameter (LVEDD), cardiac output (CO), cardiac index (CI), left ventricular systolic pressure (LVSP), left ventricular diastolic pressure (LVDP), maximum systolic blood pressure rise rate (dp/dtmax), maximum diastolic blood pressure drop rate (-dp/dtmax), heart rate (HR), peripheral renin, norepinephrine, angiotensin II, aldosterone, glomerular filtration rate (GFR) and renal blood flow were measured. Statistical analysis was performed with SPSS version 17.0. Results: The peripheral renin, norepinephrine, angiotensin II, aldosterone, LVDP, LVESD and LVEDD in RSDN group were significantly lower than in control group, but the left ventricular ejection fraction, CI, CO, LVSP, dp/dtmax, and -dp/dtmax in RSDN group were markedly higher than in control group. Conclusion: In heart failure dogs, RSDN may inhibit the renal sympathetic activity and reduce systemic sympathetic activity, attenuate heart enlargement, mitigate reduced myocardial contractility, suppress the myocardial remodeling due to right ventricular pacing induced heart failure and improve the symptoms of heart failure and cardiac function.
出版者	E-Century Publishing Corporation40 White Oaks LaneMadisonWI 53711
ISSN	1940-5901
卷号	9 期号:2 页码:4324-4331
收录类别	SCOPUS
URL	查看原文
SCOPUSEID	2-s2.0-84962256845
通讯作者地址	[Lu, Yingmin]Department of Cardiology,Xin Hua (Chongming) Hospital Affiliated to Shanghai Jiao Tong University,School of Medicine,Shanghai,200092,China
Scopus学科分类	Biochemistry, Genetics and Molecular Biology (all)
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/185571
专题	第一临床医学院（信息与工程学院）、附属第一医院_急诊医学
通讯作者	Lu, Yingmin
作者单位	1.Department of Cardiology,Xin Hua (Chongming) Hospital Affiliated to Shanghai Jiao Tong University,School of Medicine,Shanghai,200092,China; 2.Department of Emergency Medicine,Wenzhou Central Hospital,Affiliated Dingli Clinical Institute of Wenzhou Medical University,Zhejiang,China
推荐引用方式 GB/T 7714	Huang, Damin,Li, Yong,Hou, Shuxin,et al. Influence of renal sympathetic denervation on the cardiac function of dogs with heart failure[J]. International Journal of Clinical and Experimental Medicine;,2016,9(2):4324-4331.
APA	Huang, Damin, Li, Yong, Hou, Shuxin, Zhang, Jinchun, Song, Lei, & Lu, Yingmin. (2016). Influence of renal sympathetic denervation on the cardiac function of dogs with heart failure. International Journal of Clinical and Experimental Medicine;, 9(2), 4324-4331.
MLA	Huang, Damin,et al."Influence of renal sympathetic denervation on the cardiac function of dogs with heart failure".International Journal of Clinical and Experimental Medicine; 9.2(2016):4324-4331.