Ferulic acid increases pain threshold and ameliorates depression-like behaviors in reserpine-treated mice: behavioral and neurobiological analyses

doi:10.1007/s11011-013-9404-4

科研成果详情

题名	Ferulic acid increases pain threshold and ameliorates depression-like behaviors in reserpine-treated mice: behavioral and neurobiological analyses
作者	Xu, Ying 1,2; Zhang, Lu 1; Shao, Tuo1; Ruan, Lina1; Wang, Lin 1; Sun, Jiao 1; Li, Jianxin1; Zhu, Xinbo1; O'Donnell, James M.2; Pan, Jianchun1
发表日期	2013-12
发表期刊	METABOLIC BRAIN DISEASE 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Ferulic acid Depression-pain dyad Antidepressant effect Hyperalgesia Allodynia
其他关键词	NEUROPATHIC PAIN ; RATS ; ANTIDEPRESSANTS ; CURCUMIN ; PATHOPHYSIOLOGY ; COMORBIDITY ; MECHANISMS ; REDUCTASE ; SYMPTOMS ; PATHWAYS
摘要	Depression-pain dyad involves a series of pathological changes including the dysfunction of neuroendocrine and immune networks. Depression and pain influence each other, but the mechanisms are still obscure. The present study aimed to investigate the effect of ferulic acid (FA) on reserpine-induced pain and depression-like behaviors in mice. The results showed that reserpine (1 mg/kg for 3 days, i.p.) led to a significant decrease in nociceptive threshold in thermal hyperalgesia and mechanical allodynia, as well as a significant increase in the immobility time in mouse models of despair test. The neurochemical assays suggested the decreased neurotransmitters (dopamine, norepinephrine and serotonin) along with the increased oxidative stress, inflammatory cytokines, and apoptotic parameters in the frontal cortex and hippocampus of the reserpinised mice. Treatment with FA (40 or 80 mg/kg, p.o.) reversed the behavioral abnormalities and decreased norepinephrine, serotonin and dopamine levels in the hippocampus and frontal cortex induced by reserpine. The higher dose of FA effectively antagonized the oxidative and nitrosative stress and inflammation as evidenced by down-regulated nitrite, LPO, IL-1 beta, TNF-alpha, and up-regulated GSH and SOD. Furthermore, FA produced a dose dependent decrease in substance P, NF-kappa I-2 p65 and caspase-3 levels in the frontal cortex and hippocampus of reserpinised mice. The findings suggest that FA exerts the effects on reserpine-induced pain and depression-like behaviors through regulating monoaminergic system, oxidative/antioxidant defense, inflammatory and apoptotic signaling pathways. Understanding the mechanism by which FA ameliorates depression and pain as a multi-targeted compound could open new avenues for the development of innovative treatments for depression coupled with pain.
资助项目	National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [30901802]; Wenzhou City Science & Technology Plan Item [Y20100201]; Wenzhou Science and Technology Bureau Awards [Y20080097]; Ruian City Science & Technology Plan Item [201002063]
出版者	SPRINGER/PLENUM PUBLISHERS
出版地	NEW YORK
ISSN	0885-7490
EISSN	1573-7365
卷号	28 期号:4 页码:571-583
DOI	10.1007/s11011-013-9404-4
页数	13
WOS类目	Endocrinology & Metabolism ; Neurosciences
WOS研究方向	Endocrinology & Metabolism ; Neurosciences & Neurology
WOS记录号	WOS:000326106200005
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	23584961
SCOPUSEID	2-s2.0-84887244597
通讯作者地址	[Xu, Ying]Departments of Behavioral Medicine and Psychiatry and Neurobiology and Anatomy,West Virginia University,Health Sciences Center,United States
Scopus学科分类	Biochemistry;Neurology (clinical);Cellular and Molecular Neuroscience
引用统计	被引频次：50[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/18507
专题	药学院（分析测试中心）_实验神经生物研究所
通讯作者	Xu, Ying
作者单位	1.Institute of Experimental Neurobiology,Wenzhou Medical College,China; 2.Departments of Behavioral Medicine and Psychiatry and Neurobiology and Anatomy,West Virginia University,Health Sciences Center,United States
第一作者单位	温州医科大学
第一作者的第一单位	温州医科大学
推荐引用方式 GB/T 7714	Xu, Ying,Zhang, Lu,Shao, Tuo,et al. Ferulic acid increases pain threshold and ameliorates depression-like behaviors in reserpine-treated mice: behavioral and neurobiological analyses[J]. METABOLIC BRAIN DISEASE,2013,28(4):571-583.
APA	Xu, Ying., Zhang, Lu., Shao, Tuo., Ruan, Lina., Wang, Lin., ... & Pan, Jianchun. (2013). Ferulic acid increases pain threshold and ameliorates depression-like behaviors in reserpine-treated mice: behavioral and neurobiological analyses. METABOLIC BRAIN DISEASE, 28(4), 571-583.
MLA	Xu, Ying,et al."Ferulic acid increases pain threshold and ameliorates depression-like behaviors in reserpine-treated mice: behavioral and neurobiological analyses".METABOLIC BRAIN DISEASE 28.4(2013):571-583.