LncRNA FLVCR1-AS1 accelerates osteosarcoma cells to proliferate, migrate and invade via activating wnt/β-catenin pathway

科研成果详情

题名	LncRNA FLVCR1-AS1 accelerates osteosarcoma cells to proliferate, migrate and invade via activating wnt/β-catenin pathway
作者	Jiang, Shengbo 1; Kong, Peng 2; Liu, Xudong 1; Yuan, Cuihua 3; Peng, Kejun 4; Liang, Yimin 5
发表日期	2020-08-01
发表期刊	Journal of B.U.ON.; 影响因子和分区
语种	英语
原始文献类型	Article
关键词	FLVCR1-AS1 Osteosarcoma Wnt/β-catenin
摘要	Purpose: To clarify the biological function of long noncoding RNA (lncRNA) FLVCR1-AS1 in the progression of osteosarcoma. Methods: The correlation between FLVCR1-AS1 level and pathological indexes of osteosarcoma patients was analyzed by chi-square test. Subsequently, the regulatory effects of FLVCR1-AS1 on the proliferative, migratory and invasive abilities of osteosarcoma cells were evaluated. Moreover, the relative levels of CTNNB1, SOX4, CCND1, CCND2 and MYC in osteosarcoma cells regulated by FLVCR1-AS1 were detected by qRT-PCR. Finally, rescue experiments were conducted to verify the role of wnt/β-catenin in osteosarcoma progression. Results: LncRNA FLVCR1-AS1 was upregulated in osteosarcoma, which was positively correlated to tumor size, WHO grade and distant metastasis, but negatively correlated to survival of osteosarcoma patients. Overexpression of FLVCR1-AS1 markedly suppressed osteosarcoma cells to proliferate, migrate and invade. Relative levels of CTNNB1, SOX4, CCND1, CCND2, MYC and nucleus β-catenin were upregulated in U2OS and MG63 cells overexpressing FLVCR1-AS1. Finally, CTNNB1 knockdown was identified to reverse the influence of overexpressed FLVCR1-AS1 of osteosarcoma cells. Conclusions: FLVCR1-AS1 accelerates the progression of osteosarcoma via activating wnt/β-catenin pathway.
出版者	Zerbinis Publicationsasisath@gmail.com
ISSN	1107-0625
卷号	25 期号:4 页码:2078-2085
收录类别	SCOPUS
URL	查看原文
PubMed ID	33099956
SCOPUSEID	2-s2.0-85090482154
通讯作者地址	[Liang, Yimin]Department of Orthopedics,Huangyan Hospital of Wenzhou Medical University,Taizhou First People’s Hospital,No.218, Hengjie Rd, Huangyan District,Taizhou, Zhejiang,318020,China
Scopus学科分类	Hematology;Oncology;Radiology, Nuclear Medicine and Imaging;Cancer Research
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/185021
专题	其他_附属黄岩医院（台州市第一人民医院）
通讯作者	Liang, Yimin
作者单位	1.Department of Joint Surgery,First People’s Hospital of Lianyungang,Lianyungang,222000,China; 2.Department of Orthopaedics,Affiliated Hospital of Shandong University of Traditional Chinese Medicine,Jinan,250000,China; 3.Department of Orthopedics,Min Dong Hospital of the City of Ningde,Ningde,352000,China; 4.Department of Orthopaedics,Qianjiang National Hospital,Chongqing,409000,China; 5.Department of Orthopedics,Huangyan Hospital of Wenzhou Medical University,First People’s Hospital,Taizhou,318020,China
通讯作者单位	其他_附属黄岩医院（台州市第一人民医院）
推荐引用方式 GB/T 7714	Jiang, Shengbo,Kong, Peng,Liu, Xudong,et al. LncRNA FLVCR1-AS1 accelerates osteosarcoma cells to proliferate, migrate and invade via activating wnt/β-catenin pathway[J]. Journal of B.U.ON.;,2020,25(4):2078-2085.
APA	Jiang, Shengbo, Kong, Peng, Liu, Xudong, Yuan, Cuihua, Peng, Kejun, & Liang, Yimin. (2020). LncRNA FLVCR1-AS1 accelerates osteosarcoma cells to proliferate, migrate and invade via activating wnt/β-catenin pathway. Journal of B.U.ON.;, 25(4), 2078-2085.
MLA	Jiang, Shengbo,et al."LncRNA FLVCR1-AS1 accelerates osteosarcoma cells to proliferate, migrate and invade via activating wnt/β-catenin pathway".Journal of B.U.ON.; 25.4(2020):2078-2085.