科研成果详情

题名Association of Thyroid Peroxidase Antibodies and Thyroglobulin Antibodies with Thyroid Function in Pregnancy: An Individual Participant Data Meta-Analysis
作者
发表日期2022-07-01
会议录名称Mary Ann Liebert Inc.   影响因子和分区
语种英语
原始文献类型Conference Paper
关键词meta-Analysis pregnancy thyroglobulin antibodies thyroid thyroid autoimmunity thyroid peroxidase antibodies
摘要Objectives: Thyroid autoimmunity is common in pregnant women and associated with thyroid dysfunction and adverse obstetric outcomes. Most studies focus on thyroid peroxidase antibodies (TPOAbs) assessed by a negative-positive dichotomy and rarely take into account thyroglobulin antibodies (TgAbs). This study aimed at determining the association of TPOAbs and TgAbs, respectively, and interdependently, with maternal thyroid function. Methods: This was a meta-Analysis of individual participant cross-sectional data from 20 cohorts in the Consortium on Thyroid and Pregnancy. Women with multiple pregnancy, pregnancy by assisted reproductive technology, history of thyroid disease, or use of thyroid interfering medication were excluded. Associations of (log2) TPOAbs and TgAbs (with/without mutual adjustment) with cohort-specific z-scores of (log2) thyrotropin (TSH), free triiodothyronine (fT3), total triiodothyronine (TT3), free thyroxine (fT4), total thyroxine (TT4), or triiodothyronine:thyroxine (T3:T4) ratio were evaluated in a linear mixed model. Results: In total, 51,138 women participated (51,094 had TPOAb-data and 27,874 had TgAb-data). Isolated TPOAb positivity was present in 4.1% [95% confidence interval, CI: 3.0 to 5.2], isolated TgAb positivity in 4.8% [CI: 2.9 to 6.6], and positivity for both antibodies in 4.7% [CI: 3.1 to 6.3]. Compared with antibody-negative women, TSH was higher in women with isolated TPOAb positivity (z-score increment 0.40, CI: 0.16 to 0.64) and TgAb positivity (0.21, CI: 0.10 to 0.32), but highest in those positive for both antibodies (0.54, CI: 0.36 to 0.71). There was a dose-response effect of higher TPOAb and TgAb concentrations with higher TSH (TSH z-score increment for TPOAbs 0.12, CI: 0.09 to 0.15, TgAbs 0.08, CI: 0.02 to 0.15). When adjusting analyses for the other antibody, only the association of TPOAbs remained statistically significant. A higher TPOAb concentration was associated with lower fT4 (p < 0.001) and higher T3:T4 ratio (0.09, CI: 0.03 to 0.14), however, the association with fT4 was not significant when adjusting for TgAbs (p = 0.16). Conclusions: This individual participant data meta-Analysis demonstrated an increase in TSH with isolated TPOAb positivity and TgAb positivity, respectively, which was amplified for individuals positive for both antibodies. There was a dose-dependent association of TPOAbs, but not TgAbs, with TSH when adjusting for the other antibody. This supports current practice of using TPOAbs in initial laboratory testing of pregnant women suspected of autoimmune thyroid disease. However, studies on the differences between TPOAb-And TgAb-positive women are needed to fully understand the spectrum of phenotypes.
资助项目US Department of Veterans Affairs Health Services Research & Development Service of the VA Office of Research and Development[1I21HX003268-01A1];Netherlands Organization for Scientific Research[401.16.020];Ministry of Health Care of Russian Federation[121031100288-5]
出版者Mary Ann Liebert Inc.
ISSN1050-7256
EISSN1557-9077
卷号32
期号7
页码828-840
DOI10.1089/thy.2022.0083
收录类别SCOPUS
URL查看原文
Pubmed记录号35596568
Scopus记录号2-s2.0-85134265107
通讯作者地址[Feldt-Rasmussen, Ulla]Department of Medical Endocrinology and Metabolism,Copenhagen University Hospital,Rigshospitalet,Copenhagen,Denmark
Scopus学科分类Endocrinology, Diabetes and Metabolism;Endocrinology
TOP期刊TOP期刊
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文献类型会议论文
条目标识符https://kms.wmu.edu.cn/handle/3ETUA0LF/184908
专题其他_附属第三医院(瑞安市人民医院)
通讯作者Feldt-Rasmussen, Ulla
作者单位
1.Department of Medical Endocrinology and Metabolism,Copenhagen University Hospital,Rigshospitalet,Copenhagen,Denmark;
2.Department of Internal Medicine,Erasmus University Medical Center,Rotterdam,Netherlands;
3.Academic Center for Thyroid Diseases,Erasmus University Medical Center,Rotterdam,Netherlands;
4.Section of Biostatistics,Department of Public Health,Copenhagen University,Copenhagen,Denmark;
5.Dept. of Endocrinol. and Rui'an Ctr. of the Chinese-Amer. Res. Institute for Diabetic Complications,Third Affiliated Hospital of Wenzhou Medical University,Wenzhou,China;
6.Northern Finland Laboratory Center Nordlab and Medical Research Center Oulu,Oulu University Hospital and University of Oulu,Oulu,Finland;
7.Harris Birthright Research Center for Fetal Medicine,King's College Hospital,London,United Kingdom;
8.Department of Maternal Child and Adolescent Health,School of Public Health,Anhui Medical University,Hefei,China;
9.Anhui Provincial Key Laboratory of Population Health and Aristogenics,Hefei,China;
10.Department of Endocrinology and Diabetes,Sir Charles Gairdner Hospital,Nedlands,Australia;
11.Department of Preventive Medicine,Keck School of Medicine,University of Southern California,Los Angeles,United States;
12.Center for Environmental and Health Sciences,Hokkaido University,Sapporo,Japan;
13.Institute of Endocrinology,Almazov National Medical Research Centre,St. Petersburg,Russian Federation;
14.Thyroid Research Group,Institute of Molecular and Experimental Medicine,School of Medicine,Cardiff University,Cardiff,United Kingdom;
15.Research and Innovation,Shalamar Institute of Health Sciences,Lahore,Pakistan;
16.Department of Endocrinology,Royal Devon and Exeter Hospital Nhs Foundation Trust,University of Exeter Medical School,Exeter,United Kingdom;
17.University of Exeter Medical School,Royal Devon & Exeter Hospital,Exeter,United Kingdom;
18.Endocrinology Department and Center of Translational Endocrinology (CETREN),Department of Endocrinology,Faculty of Medicine,Pontificia Universidad Católica de Chile,Santiago,Chile;
19.Division of Chronic Disease Research Across the Lifecourse,Department of Population Medicine Hypertension and Diabetes,Brigham and Women's Hospital,Harvard Medical School,Boston,United States;
20.Division of Endocrinology,Hypertension and Diabetes Brigham and Women's Hospital,Harvard Medical School,Boston,United States;
21.Division of Endocrinology and Metabolism,University of Arkansas for Medical Sciences,Little Rock,United States;
22.Knowledge and Evaluation Research Unit,Division of Endocrinology Diabetes,Metabolism and Nutrition,Department of Medicine,Mayo Clinic,Rochester,United States;
23.Central Arkansas Veterans Healthcare System,Little Rock,United States;
24.Maternal-Fetal Metabolic Research Group,Girona Biomedical Research Institute (IDIBGI),Dr. Josep Trueta Hospital,Spain,Girona,Spain;
25.Shifa Institute of Medical Technology,Shifa International Hospital,Islamabad,Pakistan;
26.Pediatric Endocrinology Research Group,Girona Biomedical Research Institute (IDIBGI),Dr. Josep Trueta Hospital,Girona,Spain;
27.Division of Endocrinology,Department of Medicine,Memorial Sloan-Kettering Cancer Center,Weill Cornell University,New York,United States;
28.Section of Endocrinology Diabetes and Nutrition,Boston University School of Medicine,Boston,United States;
29.School of Medicine,University of Glasgow,Glasgow,United Kingdom;
30.Department of Public Health,Amsterdam Umc,University of Amsterdam,Amsterdam Public Health Research Institute,Amsterdam,Netherlands;
31.Department of Internal Diseases and Endocrinology,St. Petersburg Pavlov State Medical University,St. Petersburg,Russian Federation;
32.World-Class Research Center for Personalized Medicine,Almazov National Medical Research Centre,St. Petersburg,Russian Federation;
33.Medical School,University of Western Australia,Crawley,Australia;
34.Department of Women and Children's Health,Faculty of Life Sciences and Medicine,King's College London,London,United Kingdom;
35.Department of Obstetrics and Gynecology and Medical Research Center Oulu,University of Oulu,Oulu,Finland;
36.Department of Medical and Clinical Psychology,Tilburg University,Tilburg,Netherlands;
37.Department of Clinical Medicine,Faculty of Health and Medical Sciences,University of Copenhagen,Copenhagen,Denmark
推荐引用方式
GB/T 7714
Bliddal, Sofie,Derakhshan, Arash,Xiao, Yi,et al. Association of Thyroid Peroxidase Antibodies and Thyroglobulin Antibodies with Thyroid Function in Pregnancy: An Individual Participant Data Meta-Analysis[C]:Mary Ann Liebert Inc.,2022:828-840.

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