Can single-cell RNA sequencing reshape the clinical biochemistry of haematology? New clusters of circulating blood cells

doi:10.1002/ctd2.19

科研成果详情

名称	Can single-cell RNA sequencing reshape the clinical biochemistry of haematology? New clusters of circulating blood cells
作者	Fang, Hao 1,2; Zeng, Yiming 3; Zhang, Lianzhong 4; Chen, Chengshui 5; Powell, Charles A.6; Wang, Xiangdong 7
发表期刊	Clinical and Translational Discovery;
语种	英语
原始文献类型	Editorial
关键词	biochemistry blood cells circulating clinic scRNA-seq
摘要	scRNA-seq is on track for use as a routine measurement of clinical biochemistry and to assist in clinical decision-making and guide the performance of molecular medicine, but there are still a large number of challenges to be overcome. In conclusion, scRNA-seq-based clusters and differentiations of circulating blood cells have been examined and informative in patients with various diseases, although the information generated from scRNA-seq varies between different conditions, technologies and diseases. Most of the clinical studies published have focused on the landscape of circulating immune cells, disease-specific patterns of new clusters, understanding of potential mechanisms, and potential correlation between cell clusters, differentiations, cell interactions and circulating and migrated cells. It is clear that the information from scRNA-seq advances the understanding of the disease, identifies disease-specific target panels and suggests new therapeutic strategies. The adaptation of scRNA-seq as a routine clinical measurement will require standardisation and normalisation of scRNA-seq-based comprehensive information and validation in a large population of healthy and diseased patients. The integration of public databases on human circulating cell clusters and differentiations with application of artificial intelligent and computational science will accelerate the application of scRNA-seq for clinical practice. Thus, we call special attention from scientists and clinicians to the clinical and translational discovery, validation and medicine opportunities of scRNA-seq development.
资助项目	National Key Research and Development Program of Precision Medicine[2017YFC0909500];National Nature Science Foundation of China[81873409];
出版者	Blackwell Publishing
ISSN	2768-0622
卷号	2
期号	1
DOI	10.1002/ctd2.19
收录类别	SCOPUS
发布日期	2022-03-01
URL	查看原文
通讯作者地址	[Fang, Hao]Department of Anesthesiology,Zhongshan Hospital,Fudan University,Shanghai,China
Scopus学科分类	Cell Biology;Genetics;Clinical Biochemistry;Molecular Medicine;Medicine (all)
SCOPUSEID	SCOPUS_ID:85165496814
引用统计
文献类型	其他
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/184863
专题	其他_温州医科大学附属衢州医院
通讯作者	Fang, Hao
作者单位	1.Department of Anesthesiology,Zhongshan Hospital,Fudan University,Shanghai,China; 2.Department of Anesthesiology,Minhang Hospital,Fudan University,Shanghai,China; 3.Department of Pulmonary and Critical Care Medicine,Clinical Center for Molecular Diagnosis and Therapy,Respiratory Medicine Center of Fujian Province,Second Affiliated Hospital of Fujian Medical University,Quanzhou,China; 4.Henan Provincial People's Hospital,People's Hospital of Henan University,People's Hospital of Zhengzhou University,Zhengzhou,China; 5.Quzhou People's Hospital,The Quzhou Affiliated Hospital of Wenzhou Medical University,Zhejiang,Quzhou,China; 6.Division of Pulmonary,Critical Care and Sleep Medicine,Icahn School of Medicine at Mount Sinai,New York,United States; 7.Department of Pulmonary and Critical Care Medicine,Shanghai Institute of Clinical Bioinformatics,Shanghai Engineering Research for AI Technology for Cardiopulmonary Diseases,Jinshan Hospital Centre for Tumor Diagnosis and Therapy,Fudan University Shanghai Medical College,Shanghai,China
推荐引用方式 GB/T 7714	Fang, Hao,Zeng, Yiming,Zhang, Lianzhong,et al. Can single-cell RNA sequencing reshape the clinical biochemistry of haematology? New clusters of circulating blood cells. 2022.