Progress in salivary glands: Endocrine glands with immune functions

doi:10.3389/fendo.2023.1061235

科研成果详情

名称	Progress in salivary glands: Endocrine glands with immune functions
作者	Shang, Yu Feng 1; Shen, Yi Yang 1; Zhang, Meng Chen 2; Lv, Min Chao 3; Wang, Tong Ying 2,4; Chen, Xue Qun 2,4; Lin, Jun 1
发表期刊	Frontiers in Endocrinology;
语种	英语
原始文献类型	Short Survey
关键词	endocrine gland immune function neuroendocrine saliva salivary gland
摘要	The production and secretion of saliva is an essential function of the salivary glands. Saliva is a complicated liquid with different functions, including moistening, digestion, mineralization, lubrication, and mucosal protection. This review focuses on the mechanism and neural regulation of salivary secretion, and saliva is secreted in response to various stimuli, including odor, taste, vision, and mastication. The chemical and physical properties of saliva change dynamically during physiological and pathophysiological processes. Moreover, the central nervous system modulates salivary secretion and function via various neurotransmitters and neuroreceptors. Smell, vision, and taste have been investigated for the connection between salivation and brain function. The immune and endocrine functions of the salivary glands have been explored recently. Salivary glands play an essential role in innate and adaptive immunity and protection. Various immune cells such as B cells, T cells, macrophages, and dendritic cells, as well as immunoglobins like IgA and IgG have been found in salivary glands. Evidence supports the synthesis of corticosterone, testosterone, and melatonin in salivary glands. Saliva contains many potential biomarkers derived from epithelial cells, gingival crevicular fluid, and serum. High level of matrix metalloproteinases and cytokines are potential markers for oral carcinoma, infectious disease in the oral cavity, and systemic disease. Further research is required to monitor and predict potential salivary biomarkers for health and disease in clinical practice and precision medicine.
资助项目	National Natural Science Foundation of China[32120103007,81930054,81970978];
出版者	Frontiers Media S.A.
ISSN	1664-2392
卷号	14
DOI	10.3389/fendo.2023.1061235
收录类别	SCOPUS
发布日期	2023-02-03
URL	查看原文
通讯作者地址	[Lin, Jun]Department of Stomatology,Key Laboratory of Oral Biomedical Research of Zhejiang Province,The First Affiliated Hospital,School of Medicine,Zhejiang University,Zhejiang University School of Stomatology,Hangzhou,China
Scopus学科分类	Endocrinology, Diabetes and Metabolism
SCOPUSEID	SCOPUS_ID:85148446843
引用统计
文献类型	其他
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/184817
专题	其他_温州医科大学附属衢州医院
通讯作者	Lin, Jun
作者单位	1.Department of Stomatology,Key Laboratory of Oral Biomedical Research of Zhejiang Province,The First Affiliated Hospital,School of Medicine,Zhejiang University,Zhejiang University School of Stomatology,Hangzhou,China; 2.National Health Commission and Chinese Academy of Medical Sciences,Key Laboratory of Medical Neurobiology,MOE Frontier Science Center for Brain Research and Brain Machine Integration,School of Brain Science and Brain Medicine,Zhejiang University,Hangzhou,China; 3.Department of Orthopedics,The Quzhou Affiliated Hospital of Wenzhou Medical University,Quzhou People’s Hospital,Quzhou,China; 4.Department of Neurobiology,Department of Neurology of the Second Affiliated Hospital,School of Brain Science and Brain Medicine,Hangzhou,China
推荐引用方式 GB/T 7714	Shang, Yu Feng,Shen, Yi Yang,Zhang, Meng Chen,et al. Progress in salivary glands: Endocrine glands with immune functions. 2023.