Prognostic value of platelet distribution width to lymphocyte ratio in patients with hepatocellular carcinoma following hepatectomy

doi:10.1186/s12885-023-11621-8

科研成果详情

题名	Prognostic value of platelet distribution width to lymphocyte ratio in patients with hepatocellular carcinoma following hepatectomy
作者	Zhong, Zhi-Han 1; Liang, Lei 1; Fu, Tian-Wei 1; Dai, Mu-Gen 2; Cheng, Jian 1; Liu, Si-Yu 3; Ye, Tai-Wei 1,4; Shen, Guo-Liang 1; Zhang, Cheng-Wu 1; Huang, Dong-Sheng 1; Liu, Jun-Wei 1
发表日期	2023-11-16
发表期刊	BMC Cancer; 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Hepatectomy Hepatocellular carcinoma Platelet distribution width Platelets-lymphocyte-ratio Prognosis
其他关键词	CANCER ; RECURRENCE ; SURVIVAL
摘要	Background: Platelet distribution width (PDW), but not platelet count, was found to more comprehensively reflect platelet activity. The present study, thus, aimed to evaluate the prognostic value of PDW to lymphocyte ratio (PDWLR) in patients with hepatocellular carcinoma (HCC) following hepatectomy. Methods: Patients following hepatectomy were analyzed retrospectively. The Kaplan-Meier survival curves and Cox regression model were used to determine the prognostic value of PDWLR. Results: 241 patients were analyzed eventually, and stratified into low and high PDWLR groups (≤ 9.66 vs. > 9.66). Results of comparing the baseline characteristics showed that high PDWLR was significantly associated with cirrhosis, and intraoperative blood loss (all P < 0.05). In multivariate COX regression analysis, PDWLR was demonstrated as an independent risk factor for OS (HR: 1.549, P = 0.041) and RFS (HR: 1.655, P = 0.005). Moreover, PDWLR demonstrated a superior capacity for predicting prognosis compared to other indicators. Conclusion: Preoperative PDWLR has a potential value in predicting the prognosis of HCC patients following hepatectomy, which may help in clinical decision-making for individual treatment.
资助项目	Natural Science Foundation of China[82302915];Zhejiang Provincial Natural Science Foundation of China[LQ23H160049];Health Commission of Zhejiang Province[2022KY532];Zhejiang Provincial People’s Hospital[ZRY2020A004];
出版者	BMC
ISSN	1471-2407
EISSN	1471-2407
卷号	23 期号:1
DOI	10.1186/s12885-023-11621-8
页数	8
WOS类目	Oncology
WOS研究方向	Oncology
WOS记录号	WOS:001106209400001
收录类别	SCOPUS ; PUBMED ; SCIE
URL	查看原文
PubMed ID	37974129
SCOPUSEID	2-s2.0-85177079956
通讯作者地址	[Liang, Lei]General Surgery,Cancer Center,Department of Hepatobiliary & Pancreatic Surgery and Minimally Invasive Surgery,Affiliated People’s Hospital,Zhejiang Provincial People’s Hospital,Hangzhou Medical College,Zhejiang,Hangzhou,310014,China ; [Liu, Jun-Wei]General Surgery,Cancer Center,Department of Hepatobiliary & Pancreatic Surgery and Minimally Invasive Surgery,Affiliated People’s Hospital,Zhejiang Provincial People’s Hospital,Hangzhou Medical College,Zhejiang,Hangzhou,310014,China
Scopus学科分类	Oncology;Genetics;Cancer Research
TOP期刊	TOP期刊
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/184692
专题	其他_附属第五医院（丽水市中心医院）
通讯作者	Liang, Lei; Liu, Jun-Wei
作者单位	1.General Surgery,Cancer Center,Department of Hepatobiliary & Pancreatic Surgery and Minimally Invasive Surgery,Affiliated People’s Hospital,Zhejiang Provincial People’s Hospital,Hangzhou Medical College,Zhejiang,Hangzhou,310014,China; 2.Department of Gastroenterology,The Fifth Affiliated Hospital of Wenzhou Medical University,Zhejiang Province,Wenzhou,China; 3.Department of Laboratory Medicine,The Key Laboratory of Imaging Diagnosis and Minimally Invasive Interventional Research of Zhejiang Province,Zhejiang University Lishui Hospital,Zhejiang,Lishui,China; 4.Department of the Second School of Clinical Medicine,Zhejiang Chinese Medical University,Zhejiang,Hangzhou,China
推荐引用方式 GB/T 7714	Zhong, Zhi-Han,Liang, Lei,Fu, Tian-Wei,et al. Prognostic value of platelet distribution width to lymphocyte ratio in patients with hepatocellular carcinoma following hepatectomy[J]. BMC Cancer;,2023,23(1).
APA	Zhong, Zhi-Han., Liang, Lei., Fu, Tian-Wei., Dai, Mu-Gen., Cheng, Jian., ... & Liu, Jun-Wei. (2023). Prognostic value of platelet distribution width to lymphocyte ratio in patients with hepatocellular carcinoma following hepatectomy. BMC Cancer;, 23(1).
MLA	Zhong, Zhi-Han,et al."Prognostic value of platelet distribution width to lymphocyte ratio in patients with hepatocellular carcinoma following hepatectomy".BMC Cancer; 23.1(2023).